galectin-3

货号 (SKU)	包装规格	是否现货	价格	数量
rp174094-500μg	500μg	期货
rp174094-1mg	1mg	期货

基本描述

产品名称	galectin-3

产品规格参数

CAS编号和信息	rp174094

数据库链接

UniProtKB	P17931
Ensembl Gene	ENSG00000131981
Wikipedia	Galectin-3
ChEMBL Target	CHEMBL4531

关联配体

Ligand ID

6619

名称

galectin-3

别名

galectin 3

类别

Peptide

学名

4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide

生物活性评价

The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).

评价

Galectin 3 (Gal-3) is one of a group of 14 lectins that bind β-galactoside-containing carbohydrates, via a carbohydrate recognition domain (CRD), and it binds to . It plays regulatory functions in multiple biological processes, including cell-cell adhesion, cell-matrix interactions, macrophage activation, leukocyte migration, inflammation, angiogenesis, metastasis, apoptosis and fibrosis. Galectin 3 is being investigated as a molecular target for the development of novel therapeutics for cancer , cardiovascular disease and fibrosis (e.g. liver fibrosis in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) ) . GM-MD-02 (Galectin Therapeutics) is a galactoarabino-rhamnogalacturonan polysaccharide polymer (pectin) that binds to Gal-3 (K_d 8 μM: Gal-1 K_d 10 μM)) and reduces inflammation and fibrosis-associated effects in experimental models , but no clinical efficacy was observed in Phase 2 evaluation in patients with NASH cirrhosis (NCT02462967), although in the subset of patients with cirrhosis who had no esophageal varices some clinical benefit has been indicated, and Phase 3 testing in this subset of cirrhosis patients is planned.
In relation to cardiovascular disease, galectin 3/galectin 3 binding protein complexes co-localize to the leukocyte/endothelial cell interface of vein walls in mice and galectin 3 increases vein wall IL-6 levels and promotes venous thrombosis . In human patients, elevated circulating galectin-3 binding protein correlates with acute venous thrombosis.

配体家族

Galectins

基因/前体

Gene symbol	Gene name	Precursor protein name	Species	别名
LGALS3	galectin 3	galectin-3	Human	lectin, galactoside-binding, soluble, 3

单字母多肽序列

ADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDIDLTSASYTMI

三字母多肽序列

翻译后修饰

化学修饰

临床描述

This is a Phase 1, randomized, double-blind, placebo-controlled, first-in-human study in which the safety, tolerability, and pharmacokinetics of orally administered GB1211 will be evaluated in healthy adult subjects and adult subjects with indication of suspected Nonalcoholic steatohepatitis (NASH) and liver fibrosis.

来源公司

Galecto Biotech AB

参考文献

1. Henderson NC, Sethi T. (2009) The regulation of inflammation by galectin-3.. Immunol Rev, 230 (1): (160-71). [PMID:19594635]
2. de Boer RA, Voors AA, Muntendam P, van Gilst WH, van Veldhuisen DJ. (2009) Galectin-3: a novel mediator of heart failure development and progression.. Eur J Heart Fail, 11 (9): (811-7). [PMID:19648160]
3. Streetly MJ, Maharaj L, Joel S, Schey SA, Gribben JG, Cotter FE. (2010) GCS-100, a novel galectin-3 antagonist, modulates MCL-1, NOXA, and cell cycle to induce myeloma cell death.. Blood, 115 (19): (3939-48). [PMID:20190189]
4. Delaine T, Collins P, MacKinnon A, Sharma G, Stegmayr J, Rajput VK, Mandal S, Cumpstey I, Larumbe A, Salameh BA et al.. (2016) Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition.. Chembiochem, 17 (18): (1759-70). [PMID:27356186]
5. Harazono Y, Kho DH, Balan V, Nakajima K, Zhang T, Hogan V, Raz A. (2014) Galectin-3 leads to attenuation of apoptosis through Bax heterodimerization in human thyroid carcinoma cells.. Oncotarget, 5 (20): (9992-10001). [PMID:25393982]
6. DeRoo EP, Wrobleski SK, Shea EM, Al-Khalil RK, Hawley AE, Henke PK, Myers DD Jr, Wakefield TW, Diaz JA. (2015) The role of galectin-3 and galectin-3-binding protein in venous thrombosis.. Blood, 125 (11): (1813-21). [PMID:25428218]
7. Nakajima K, Kho DH, Yanagawa T, Harazono Y, Hogan V, Chen W, Ali-Fehmi R, Mehra R, Raz A. (2016) Galectin-3 Cleavage Alters Bone Remodeling: Different Outcomes in Breast and Prostate Cancer Skeletal Metastasis.. Cancer Res, 76 (6): (1391-402). [PMID:26837763]
8. Sumida Y, Yoneda M. (2018) Current and future pharmacological therapies for NAFLD/NASH.. J Gastroenterol, 53 (3): (362-376). [PMID:29247356]
9. Chan YC, Lin HY, Tu Z, Kuo YH, Hsu SD, Lin CH. (2018) Dissecting the Structure-Activity Relationship of Galectin-Ligand Interactions.. Int J Mol Sci, 19 (2): (1755-70). [PMID:29382172]

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galectin-3

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库存信息

基本描述

产品规格参数

数据库链接

关联配体

参考文献

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galectin-3

库存信息

库存信息

基本描述

产品规格参数

数据库链接

关联配体

参考文献

相关文档

质检报告COA

产品问答

产品问答

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