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基本描述
| 产品名称 | galectin-1 |
|---|
产品规格参数
| CAS编号和信息 | rp174093 |
|---|
数据库链接
| UniProtKB | P09382 |
|---|---|
| Ensembl Gene | ENSG00000100097 |
| Wikipedia | Galectin-1 |
关联配体
| Ligand ID | 6603 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | galectin-1 | ||||||||||
| 别名 | GBP | ||||||||||
| 类别 | Peptide | ||||||||||
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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| 评价 | Gal-1 is a mammalian lectin that is active in the immune system. Its participation in the induction of self-tolerance suggests that any altered activity could lead to a failure to select out autoreactive cells, which may be relevant to autoimmune disease pathogenesis. | ||||||||||
| 配体家族 | Galectins | ||||||||||
| 基因/前体 |
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| 单字母多肽序列 | GLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD | ||||||||||
| 三字母多肽序列 | |||||||||||
| 翻译后修饰 | |||||||||||
| 化学修饰 |
参考文献
| 1. Baum LG, Blackall DP, Arias-Magallano S, Nanigian D, Uh SY, Browne JM, Hoffmann D, Emmanouilides CE, Territo MC, Baldwin GC. (2003) Amelioration of graft versus host disease by galectin-1.. Clin Immunol, 109 (3): (295-307). [PMID:14697744] |
| 2. Espeli M, Mancini SJ, Breton C, Poirier F, Schiff C. (2009) Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions.. Blood, 113 (23): (5878-86). [PMID:19329777] |
| 3. Alhabbab R, Blair P, Smyth LA, Ratnasothy K, Peng Q, Moreau A, Lechler R, Elgueta R, Lombardi G. (2018) Galectin-1 is required for the regulatory function of B cells.. Sci Rep, 8 (1): (2725). [PMID:29426942] |
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