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FGF-23

有货

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
rp174001-500μg	500μg	期货
rp174001-1mg	1mg	期货

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基本描述

产品名称	FGF-23

产品规格参数

CAS编号和信息	rp174001

数据库链接

UniProtKB	Q9GZV9
Ensembl Gene	ENSG00000118972
Entrez Gene	8074
Wikipedia	Fibroblast_growth_factor_23

关联配体

Ligand ID	9291
名称	FGF-23
别名	fibroblast growth factor 23
类别	Peptide
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	FGF-23 regulates phosphate homeostasis and calcium transport in the kidney . The full-length 327 amino acid protein is functional, and is deactivated by proteolytic cleavage which generates N-terminal and C-terminal chains. Mutation of the cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR), and other gene alterations are associated with hyperphosphatemic familial tumoral calcinosis (HFTC). Antibody-driven inactivation of FGF-23 is being investigated as a pharmacological intervention in these indications. (KRN23) is one such FGF-23 neutralising antibody in clinical development. A FGFR1 isoform [FGFR1(IIIc)] in complex with the Klotho protein (KL; Q9UEF7) forms a high affinity receptor for FGF-23 .
配体家族	Fibroblast growth factor (FGF) family ligands
单字母多肽序列	YPNASPLLGSSWGGLIHLYTATARNSYHLQIHKNGHVDGAPHQTIYSALMIRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQHQTLENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPPYSQFLSRRNEIPLIHFNTPIPRRHTRSAEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLGVVRGGRVNTHAGGTGPEGCRPFAKFI
三字母多肽序列
翻译后修饰
化学修饰

参考文献

1. Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S, Yamashita T. (2006) Klotho converts canonical FGF receptor into a specific receptor for FGF23.. Nature, 444 (7120): (770-4). [PMID:17086194]
2. Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, Rosenblatt KP, Baum MG, Schiavi S, Hu MC, Moe OW et al.. (2006) Regulation of fibroblast growth factor-23 signaling by klotho.. J Biol Chem, 281 (10): (6120-3). [PMID:16436388]
3. Tsagalis G, Psimenou E, Manios E, Laggouranis A. (2009) Fibroblast growth factor 23 (FGF23) and the kidney.. Int J Artif Organs, 32 (4): (232-9). [PMID:19569031]
4. Chen G, Liu Y, Goetz R, Fu L, Jayaraman S, Hu MC, Moe OW, Liang G, Li X, Mohammadi M. (2018) α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling.. Nature, 553 (7689): (461-466). [PMID:29342138]

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