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基本描述
| 产品名称 | FGF-21 |
|---|
产品规格参数
| CAS编号和信息 | rp174000 |
|---|
数据库链接
| UniProtKB | Q9NSA1 |
|---|---|
| Ensembl Gene | ENSG00000134962 |
| Entrez Gene | 26291 |
| RefSeq Protein | NP_061986 |
| RefSeq Nucleotide | NM_019113 |
关联配体
| Ligand ID | 11721 |
|---|---|
| 名称 | FGF-21 |
| 别名 | fibroblast growth factor 21 |
| 类别 | Peptide |
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide |
| 生物活性评价 |
FGF21 can signal through FGFR1-3 that are bound by βKlotho. This mechanism increases glucose uptake in adipocytes that express FGFR1 |
| 评价 |
FGF21 is a mitogen that is involved in the migration and differentiation of cells that are of mesodermal or neuroectodermal origin, and in metabolic regulation |
| 配体家族 | Fibroblast growth factor (FGF) family ligands |
| 单字母多肽序列 | HPIPDSSPLLQFGGQVRQRYLYTDDAQQTEAHLEIREDGTVGGAADQSPESLLQLKALKPMDSDETGFEHSGLWVSVLAGLLLGACQAGVIQILGVKTSRFLCQRPDGALYGSLHFDPEACSFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRGPARFLPLPGLPPALPEPPGILAPQPPDVGSSDPLSMVGPSQGRSPSYAS |
| 三字母多肽序列 | |
| 翻译后修饰 | |
| 化学修饰 |
参考文献
| 1. Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, Eliseenkova AV, Mohammadi M, Rosenblatt KP, Kliewer SA, Kuro-O M. (2007) Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.. J Biol Chem, 282 (37): (26687-26695). [PMID:17623664] |
| 2. Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, Sandusky GE, Hammond LJ, Moyers JS, Owens RA et al.. (2005) FGF-21 as a novel metabolic regulator.. J Clin Invest, 115 (6): (1627-35). [PMID:15902306] |
| 3. Chen X, Tong G, Fan J, Shen Y, Wang N, Gong W, Hu Z, Zhu K, Li X, Jin L et al.. (2021) FGF21 promotes migration and differentiation of epidermal cells during wound healing via SIRT1 dependent autophagy.. Br J Pharmacol, 71 (13): (1755-70). [PMID:34608629] |
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