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基本描述
| 产品名称 | BMP-15 |
|---|
产品规格参数
| CAS编号和信息 | rp173576 |
|---|
数据库链接
| UniProtKB | O95972 |
|---|---|
| Wikipedia | BMP15 |
| Ensembl Gene | ENSG00000130385 |
| CATH/Gene3D | 2.10.90.10 |
关联配体
| Ligand ID | 4880 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | BMP-15 | ||||||||||
| 别名 | growth/differentiation factor 9B | ||||||||||
| 类别 | Peptide | ||||||||||
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 生物活性评价 | We have no interaction data for this peptide. | ||||||||||
| 评价 |
The BMP-15 gene is X-linked and expressed in oocytes. BMP-15 protein appears to be involved in early ovarian folliculogenesis |
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| 配体家族 | Bone morphogenetic proteins | ||||||||||
| 基因/前体 |
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| 单字母多肽序列 | QADGISAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR | ||||||||||
| 三字母多肽序列 | |||||||||||
| 翻译后修饰 | The active peptide is a homodimer, which in contrast to other bone-morphogentic proteins is not disulphide linked. C-terminal glutamine residue is pyrrolidone carboxylic acid; serine residue at position 6 is phosphoserine; threonine resdiue at position 10 is O-linked glycosylated; asparagine resdiue at position 106 is predicted to be N-linked glycosylated; predicted disulphide bond formation between cysteine residues at positions 24 and 90, 53 and 122, and 57 and 124 | ||||||||||
| 化学修饰 |
参考文献
| 1. Aaltonen J, Laitinen MP, Vuojolainen K, Jaatinen R, Horelli-Kuitunen N, Sepp? L, Louhio H, Tuuri T, Sj?berg J, Bützow R et al.. (1999) Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis.. J Clin Endocrinol Metab, 84 (8): (2744-50). [PMID:10443672] |
| 2. Otsuka F, Yao Z, Lee T, Yamamoto S, Erickson GF, Shimasaki S. (2000) Bone morphogenetic protein-15. Identification of target cells and biological functions.. J Biol Chem, 275 (50): (39523-8). [PMID:10998422] |
| 3. Yan C, Wang P, DeMayo J, DeMayo FJ, Elvin JA, Carino C, Prasad SV, Skinner SS, Dunbar BS, Dube JL et al.. (2001) Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function.. Mol Endocrinol, 15 (6): (854-66). [PMID:11376106] |
| 4. Laitinen M, Vuojolainen K, Jaatinen R, Ketola I, Aaltonen J, Lehtonen E, Heikinheimo M, Ritvos O. (1998) A novel growth differentiation factor-9 (GDF-9) related factor is co-expressed with GDF-9 in mouse oocytes during folliculogenesis.. Mech Dev, 78 (1-2): (135-40). [PMID:9858711] |
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