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Recombinant Human LR3 IGF-1 Protein(Active)

规格或纯度: Animal Free, ≥95%(SDS-PAGE&HPLC), Active, E.coli, No tag, 40-118 aa
  • 蛋白长度: Full length protein
  • 蛋白标签: No tag

  • 应用: Active, SDS-PAGE
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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
rp155967-50μg 50μg 现货 Stock Image
rp155967-100μg 100μg 现货 Stock Image
rp155967-1mg 1mg 现货 Stock Image

基本描述

产品名称 Recombinant Human LR3 IGF-1 Protein
规格或纯度 Animal Free, ≥95%(SDS-PAGE&HPLC), Active, E.coli, No tag, 40-118 aa
产品介绍

pH值:6.5-7.5
胰岛素样生长因子-1(IGF-1)是一种分子量为7.6kD的激素,其分子结构与胰岛素类似。IGF-1的主要作用机理是通过与其特异性受体(IGF1R)结合来诱导细胞内的信号传导。IGF-1是AKT信号通路的最有效的激活因子之一,激活AKT信号通路后,刺激细胞生长及增殖,并抑制细胞凋亡。IGF-1 LR3在完整的IGF-1分子的N端添加了13个氨基酸形成83个氨基酸的长链IGF-1,并将IGF-1分子的第3个氨基酸谷氨酸(E)用精氨酸(R)取代,所以称为R3。IGF-1 LR3与未作修饰的IGF-1相比,具有更高的稳定性和生物活性。

Purity

≥95.0% SDS-PAGE&HPLC.


Function

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.??


生物活性 ED??<10.0 ng/ml, measured by the CHO cells, corresponding to a specific activity of > 1.0 × 10? units/mg.
种属 Human
氨基酸 40-118 aa
序列 MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA
蛋白标签 No tag
蛋白长度 Full length protein
Carrier Free Yes
AnimalFree Yes
Accession# P05019.2
来源 Recombinant
预测分子量 9.1 kDa
SDS-PAGE 10.1 kDa, under reducing conditions; 10.1 kDa, under non-reducing conditions.

产品规格参数

应用 Active, SDS-PAGE
物理外观 Lyophilized
储存缓冲液 10mM PBS, pH 7.0
复溶 Reconstitute in water to a concentration of 1mg/ml.
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 Freeze-dried powder can be stored at room temperature for 3 weeks, or frozen at -20℃ for long-term storage. After redissolving it can be refrigerated at 4℃ for at least 2-7 days.
CAS编号和信息 946870-92-4

图片

Recombinant Human LR3 IGF-1 Protein (rp155967) - Protein Bioactivity
Measured in a serum-free cell proliferation assay using MCF?7 human breast cancer cells. The ED?? for this effect is typically less than 10 ng/mL.

Recombinant Human LR3 IGF-1 Protein (rp155967) - SDS-PAGE
4μg/lane of Recombinant Human LR3 IGF-1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie? Blue staining, showing a single band at 10.1 kDa.

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