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Recombinant Human VEGF Protein(Active)

规格或纯度: GMP, >95%(SDS-PAGE), Active, Oryza sativa, No tag, 27-191 aa

蛋白长度: Full length protein
蛋白标签: No tag

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货号 (SKU)	包装规格	是否现货
rp155965-10μg	10μg	现货
rp155965-50μg	50μg	现货
rp155965-100μg	100μg	现货
rp155965-1mg	1mg	期货

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基本描述

产品名称	Recombinant Human VEGF Protein
规格或纯度	GMP, >95%(SDS-PAGE), Active, Oryza sativa, No tag, 27-191 aa
产品介绍	VEGF血管内皮生长因子（Vascular endothelial growth factor），也被称为血管通透因子（Vascular permeability factor，VPF）是一种高度特异性的促血管内皮细胞生长因子，具有促进血管通透性增加、细胞外基质变性、血管内皮细胞迁移、增殖和血管形成等作用。VEGF也被证实对单核细胞和成骨细胞具有趋化作用。 OsrhVEGF是运用基因重组技术，由水稻胚乳细胞表达并通过蛋白提纯工艺而成。 Purity >95% SDS-PAGE. VEGF permeability factor, also known as Vascular permeability factor (VPF), is a highly specific permeability factor for endothelial growth factor. It can promote the increase of vascular permeability, extracellular matrix degeneration, vascular endothelial cell migration, proliferation and angiogenesis. VEGF has also been shown to have chemotaxis on monocytes and osteoblasts. OsrhVEGF is expressed by oryza sativa and purified by protein purification technology. Background: Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult (1-3). It is a member of the PDGF family that is characterized by the presence of eight conserved cysteine residues and a cystine knot structure (4). Humans express alternately spliced isoforms of 121, 145, 165, 183, 189, and 206 amino acids (aa) in length (4). VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189 (3, 4). Isoforms other than VEGF121 contain basic heparin-binding regions and are not freely diffusible (4). Human VEGF165 shares 88% aa sequence identity with corresponding regions of mouse and rat, 96% with porcine, 95% with canine, and 93% with feline, equine and bovine VEGF, respectively. VEGF binds the type I transmembrane receptor tyrosine kinases VEGF R1 (also called Flt-1) and VEGF R2 (Flk-1/KDR) on endothelial cells (4). Although VEGF affinity is highest for binding to VEGF R1, VEGF R2 appears to be the primary mediator of VEGF angiogenic activity (3, 4). VEGF165 binds the semaphorin receptor, Neuropilin-1 and promotes complex formation with VEGF R2 (5). VEGF is required during embryogenesis to regulate the proliferation, migration, and survival of endothelial cells (3, 4). In adults, VEGF functions mainly in wound healing and the female reproductive cycle (3). Pathologically, it is involved in tumor angiogenesis and vascular leakage (6, 7). Circulating VEGF levels correlate with disease activity in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (8). VEGF is induced by hypoxia and cytokines such as IL-1, IL-6, IL-8, oncostatin M and TNF-alpha (3, 4, 9). Due to its role in angiogenesis of blood vessels, tumor and stroma cells use VEGF to stimulate formation of blood vessels and the proliferation and survival of endothelial cells. Specific immunotherapies targeting the VEGF signaling pathway include the recombinant antibody against VEGF (Bevacizumab), antibodies targeting the main VEGF receptor (VEGFR2), and small molecule inhibitors against VEGF receptor tyrosine kinases (10). Immune checkpoint inhibitors are an important tool in cancer therapies as tumor cells can hijack immune checkpoint signals to evade detection by immune cells. In addition to stimulating the formation of tumor blood vessels, VEGF has immunosuppressive effects by acting on dendritic cells to block their antigen-presenting and T cell stimulatory functions. Targeting VEGF in combination with other immune checkpoint ligands or receptors may prove more effective in immunotherapy approaches to certain cancer types (11). Because of its role in the formation of blood vessels, VEGF is also an important factor in skeletal development where blood supply and vascularization are crucial. This has made VEGF an important molecule in regenerative studies for bone repair as sustained release of VEGF has been shown to improve the efficiency of bone regeneration (12). In differentiation protocols for stems cells, VEGF is a commonly added growth factor for the transformation of induced pluripotent stem cells into hematopoietic progenitor cells used to make Natural Killer cells (13, 14). VEGF has also been used to transform intermediate mesoderm into kidney glomerular podocytes or stem cell-derived liver spheres (15, 16). VEGF may also be used in assistance of stem cell transplantations by supporting angiogenesis at sites of stem cell transplants or as a honing tool for adipose-derived mesenchymal stem cells or bone marrow stem cells to migrate to (17, 18).
生物活性	The ED50 value was lower than 10.0 ng/ml, that is, the corresponding active unit was greater than or equal to 1 x 10^5 units/mg by primary HUVECs cell proliferation method.
种属	Human
氨基酸	27-191 aa
序列	APMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQENPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
蛋白标签	No tag
蛋白长度	Full length protein
Carrier Free	Yes
AnimalFree	Yes
Accession#	P15692-4
来源	Recombinant
预测分子量	19.2 kDa
SDS-PAGE	19.2 kDa

产品规格参数

物理外观	Lyophilized
储存缓冲液	Lyophilized from solution in trehalose, Citrate monohydrate, HSA, pH 6.9
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water to a concentration of 100-200 μg/mL. Stock solutions should be stored at 4℃ for 2-7days, stored at -20℃ for lo
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycles. This product is an active protein and may elicit a biological response in vivo, handle with caution.
CAS编号和信息	127464-60-2

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Recombinant Human VEGF Protein (rp155965)

Recombinant Human VEGF Protein (rp155965)-Protein Bioactivity
Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. The ED?? for this effect is typically <10ng/mL.

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Recombinant Human VEGF Protein(Active)

库存信息

库存信息

库存信息

库存信息

基本描述

产品规格参数

图片

相关文档

质检报告COA

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Recombinant Human VEGF Protein(Active)

库存信息

库存信息

库存信息

库存信息

基本描述

产品规格参数

图片

相关文档

质检报告COA

产品问答

产品问答

91高清自产国产拍,无码免费A级毛片大全,日本 欧美 国产中文字幕,99re热视频这里只有精品视频首页

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