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Recombinant Human VCAM1 Protein(Active)

规格或纯度: Carrier Free, >92% (SDS-PAGE), Active, 293F, N-His tag,109-318 aa
  • 蛋白长度: Protein fragment
  • 蛋白标签: N-His tag

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货号 (SKU) 包装规格 是否现货 价格 数量
rp153094-10μg 10μg 现货 Stock Image
rp153094-50μg 50μg 现货 Stock Image
rp153094-100μg 100μg 现货 Stock Image
rp153094-1mg 1mg 期货 Stock Image
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基本描述

产品名称 Recombinant Human VCAM1 Protein
规格或纯度 Carrier Free, >92% (SDS-PAGE), Active, 293F, N-His tag,109-318 aa
产品介绍


Background:

VCAM-1, also known as CD106, is an immunoglobulin (Ig)-like adhesion molecule that is mainly expressed in endothelial cells and other cell types including macrophages, dendritic cells, neurons, smooth muscle cells, fibroblasts, and oocytes. It plays a critical role in inflammation by recruiting leukocytes to acute and chronic inflammation sites. Alternatively-spliced forms are known to occur, but the most common form is a type I transmembrane protein with a 674 aa extracellular domain (ECD) that includes seven C2-type immunoglobulin domains, a 22 aa transmembrane segment, and a 19 amino acid (aa) cytoplasmic tail. Within the ECD, human VCAM-1 shares 75% and 76% aa sequence identity with the mouse and rat VCAM-1, respectively. VCAM-1 binds to leukocyte integrins alpha 4 beta 1 (VLA-4) and alpha 4 beta 7. During the inflammatory adhesion mechanism, activated integrins halt rolling leukocytes and attach them firmly to the vascular endothelium. The VCAM-1:VLA-4/ alpha 4 beta 7 interaction is also thought to be involved in the extravasation of white blood cells through the blood vessel wall to sites of inflammation. ELISA techniques have shown that detectable levels of soluble VCAM-1 are present in the biological fluids of apparently normal individuals, but elevated levels of serum VCAM-1 are indicative of future Atrial Fibrillation incident as well as liver disease. Tumor cells use overexpression of VCAM-1 as means of escaping immune surveillance.


Post-translational modifications：

Sialoglycoprotein.


Function:

Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.


?
生物活性 Measured by its binding ability in a functional ELISA. Immobilized recombinant human ITGa4 at 2 μg/ml(100 μl/well) can bind Human VCAM-1, the ED50 for this effect is 0.261 μg/mL.
种属 Human
氨基酸 109-318 aa
序列 HHHHHHGTDIGSEFQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEIS
蛋白标签 N-His tag
蛋白长度 Protein fragment
Carrier Free Yes
AnimalFree No
偶联标记 No
Accession# NP_001069.1/P19320
来源 Recombinant
预测分子量 25.0 kDa
SDS-PAGE 30 kDa，under reducing conditions

产品规格参数

物理外观 Lyophilized
储存缓冲液 Lyophilized from sterile PBS, pH 7.4, containing 5% Trehalose
复溶 Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 Store at 2-8℃ for one month. Aliquot and store at -80℃ for 12 months.

图片

Recombinant Human VCAM1 Protein (rp153094)-Protein Bioactivity
The binding activity of recombinant human VCAM-1 and recombinant human ITGa4. The ED?? for this effect is <
0.261ug/mL.

Recombinant Human VCAM1 Protein (rp153094)-SDS-PAGE
3μg/lane of Recombinant Human VCAM1 was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie? Blue staining, showing a single band at 31.9 kDa.

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