| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| rp152522-5μg | 5μg |
现货  |
| |
| rp152522-20μg | 20μg |
现货 |
| |
| rp152522-100μg | 100μg |
现货 |
| |
| rp152522-1mg | 1mg |
期货 |
|
| 产品名称 | Recombinant Human TNF RII/TNFRSF1B Protein |
|---|---|
| 规格或纯度 | Carrier Free, >95%(SDS-PAGE), Active, E.coli, His&GST, 298-441aa |
| 产品介绍 |
Purity >95% SDS-PAGE. Function Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. |
| 生物活性 | The binding activity of TNFRSF1B and TNFa, the EC50 was 0.0470~0.085 μg/ml. |
| 种属 | Human |
| 氨基酸 | 298 to 441 |
| 序列 | MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKSDGSTSGSGHHHHHHSAGLVPRGSTAIGMKETAAAKF |
| 蛋白标签 | Two N-terminal Tags, His-tag and GST-tag |
| 蛋白长度 | Protein fragment |
| Carrier Free | Yes |
| AnimalFree | No |
| Accession# | P20333 |
| 来源 | Recombinant |
| 预测分子量 | 44.8 kDa |
| 应用 | Cell culture, Activity Assays, ELISA, SDS-PAGE |
|---|---|
| 物理外观 | Lyophilized |
| 储存缓冲液 | 10mM PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl |
| 复溶 | Reconstitute in ddH2O to a concentration ≤0.1mg/mL. Do not vortex. |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | Avoid repeated freeze/thaw cycles. Store at 2-8℃ for one month. Aliquot and store at -80℃ for 12 months. |
Recombinant Human TNF RII/TNFRSF1B Protein (rp152522)-Protein Bioactivity
Measured by its binding ability in a functional ELISA.Tumor Necrosis Factor Alpha (TNF-α) has been identified as an interactor of TNFRSF1B, thus a functional binding ELISA assay was conducted to detect the interaction of recombinant human TNFRSF1B and recombinant human TNF-α.?
Recombinant Human TNF RII/TNFRSF1B Protein (rp152522)-SDS-PAGE
3μg/lane of Recombinant Human VCAM1 was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie? Blue staining, showing a band at 51.3 kDa under reducing conditions and 49 kDa under non-reducing conditions.
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