| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| rp152506-10μg | 10μg |
现货  |
| |
| rp152506-50μg | 50μg |
现货 |
| |
| rp152506-100μg | 100μg |
现货 |
| |
| rp152506-1mg | 1mg |
期货 |
|
| 产品名称 | Recombinant Human TNF-alpha Protein |
|---|---|
| 规格或纯度 | GMP, ≥95% (SDS-PAGE), Active, E.coli, No tag, 77-233 aa |
| 产品介绍 |
肿瘤坏死因子α（TNF α）是一种主要由巨噬细胞和单核细胞产生的细胞因子，可参与机体的免疫反应和发炎反应。TNF α值的升高败血症、恶性肿瘤、心脏衰竭和慢性炎性疾病有着密切的关系，可作为病情、治疗效果以及预后的评估指标。同时， TNF α还是自身免疫系统疾病的关键靶点，已有多种针对TNF α开发的单抗药物上市; Purity ≥ 95% SDS-PAGE Additional sequence information Full length mature chain soluble form. N-terminal glycine. Function Tumor necrosis factor-α (TNFα) is a kind of cytokine mainly produced by macrophages and monocytes, which can participate in the immune response and inflammatory response of the body. The increase of TNFα value is closely related to sepsis, malignant tumor, heart failure and chronic inflammatory diseases, which can be used as an evaluation index of disease condition, treatment effect and prognosis. At the same time, TNFα is also a key target of autoimmune diseases. Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia. Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Post-translational The soluble form derives from the membrane form by proteolytic processing. The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1. O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid. |
| 生物活性 | Measured in a cytotoxicity assay using L?929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D (Catalog # A113142). The ED?? for this effect is typically <0.05 ng/mL. |
| 种属 | Human |
| 氨基酸 | 77 to 233 |
| 序列 | VRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVV PSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSP CQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQV YFGIIAL |
| 蛋白标签 | No tag |
| N-末端序列 | Val |
| 蛋白长度 | Full length protein |
| Carrier Free | Yes |
| AnimalFree | Yes |
| Accession# | P01375 |
| 来源 | Recombinant |
| 预测分子量 | 17.4 kD |
| 物理外观 | 液体 |
|---|---|
| 储存缓冲液 | 10mM PBS，10%甘油，pH=7.4 |
| 浓度 | Lot by Lot |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Recombinant Human TNF-alpha Protein (rp152506)-Protein Bioactivity
Measured in a cytotoxicity assay using L?929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D (Catalog # A113142). The EC?? for this effect is typically <0.05ng/mL.
Recombinant Human TNF-alpha Protein (rp152506)-SDS-PAGE
2μg/lane of Recombinant Human TNF-alpha was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie? Blue staining, showing a single band at 16 kDa.
首页
400-620-6333
危险品化学品经营许可证（带存储）