| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| rp149600-10μg | 10μg |
现货  |
| |
| rp149600-50μg | 50μg |
现货 |
| |
| rp149600-100μg | 100μg |
现货 |
| |
| rp149600-1mg | 1mg |
期货 |
|
| 产品名称 | Recombinant Human Osteoprotegerin Protein |
|---|---|
| 规格或纯度 | Animal Free, >95%(SDS-PAGE, HPLC), Active, E.coli, No tag, 22-194 aa |
| 产品介绍 |
Purity > 95 % by SDS-PAGE and HPLC analyses. Function Osteoprotegerin (OPG), also named osteoclastogenesis inhibitory factor (OCIF), and tumor necrosis factor receptor superfamily member 11B (TNFRSF11B), is a TNFRSF11B-encoded protein in humans. Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.OPG has been applied to decrease bone resorption in women with postmenopausal osteoporosis and in patients with lytic bone metastases. |
| 生物活性 | Fully biologically active when compared to standard. The ED50 as determined by neutralizing the stimulation of U937 cells is less than 10 ng/ml in the presence of 10 ng/mL soluble rHuRANKL (sRANKL). |
| 种属 | Human |
| 氨基酸 | 22-194 aa |
| 序列 | ETFPPKYLHY DEETSHQLLC DKCPPGTYLK QHCTAKWKTV CAPCPDHYYT DSWHTSDECL YCSPVCKELQ YVKQECNRTH NRVCECKEGR YLEIEFCLKH RSCPPGFGVV QAGTPERNTV CKRCPDGFFS NETSSKAPCR KHTNCSVFGL LLTQKGNATH DNICSGNSES TQK |
| 蛋白标签 | No tag |
| 蛋白长度 | Protein fragment |
| Carrier Free | Yes |
| AnimalFree | Yes |
| Accession# | O00300 |
| 来源 | Recombinant |
| 预测分子量 | 19.7 kDa |
| 应用 | Active, SDS-PAGE |
|---|---|
| 物理外观 | Lyophilized |
| 储存缓冲液 | Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB,150 mM NaCl, pH 6.0 |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportio |
| 储存温度 | -20°C储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ℃ as supplied; 1 month, 2 to 8 ℃ under sterile conditions after reconstitution; 3 months, -20 to -70 ℃under sterile conditions after reconstitut |
Recombinant Human Osteoprotegerin Protein (rp149600)-Protein Bioactivity
Fully biologically active when compared to standard. The ED???as determined by neutralizing the stimulation of U937 cells is less than 10 ng/mL, corresponding to a specific activity of > 1.0 ×10??IU/mg in the presence of 10 ng/mL soluble rHuRANKL (sRANKL).
Recombinant Human Osteoprotegerin Protein (rp149600)-SDS-PAGE
Recombinant Human Osteoprotegerin Protein was resolved with SDS-PAGE under reducing (R) and visualized by Coomassie? Blue staining, showing a single band at 20.7 kDa.
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