| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
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rp146383-10μg (试用装) 申请此免费试用装（?） 作为尊贵的客户，您每年可免费申请三次您选择的不同货号试用装产品，尽享探索与享受！
|
10μg |
现货  |
| |
|
rp146383-50μg |
50μg |
现货 |
| |
|
rp146383-100μg |
100μg |
现货 |
| |
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rp146383-1mg |
1mg |
期货 |
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| 产品名称 | Recombinant Human GDF6 Protein |
|---|---|
| 规格或纯度 | Animal Free, >95%(SDS-PAGE and HPLC), Active, E.coli, No tag, 336-455 aa |
| 产品介绍 |
Purity > 95% by SDS-PAGE and HPLC analyses. Function Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal strucutres. Seems to positively regulates differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:26643732). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38. |
| 生物活性 | Fully biologically active when compared to standard. The ED?? as determined by inducing alkaline phosphatase production of murine ATDC5 cells is less than 2.0 μg/ml, corresponding to a specific activity of > 500 IU/mg. |
| 种属 | Human |
| 氨基酸 | 336-455aa |
| 序列 | TAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR |
| 纯度 | ＞95%(SDS-PAGE and HPLC) |
| 蛋白标签 | No tag |
| 蛋白长度 | Full length protein |
| 无载体 | Yes |
| 无动物源 | Yes |
| Accession # | Q6KF10 |
| 来源 | Recombinant |
| 预测分子量 | 27.1 kDa |
| SDS-PAGE | 27.1 kDa |
| 物理外观 | Lyophilized |
|---|---|
| 储存缓冲液 | Lyophilized from a 0.2 μm filtered concentrated solution in 30 % Acetonitrile and 0.1 % TFA. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportio |
| 储存温度 | -20°C储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconst |
Recombinant Human GDF6 Protein (rp146383)-Protein Bioactivity
Fully biologically active when compared to standard. The ED???as determined by inducing alkaline phosphatase production of murine ATDC5 cells is less than 2.0 μg/mL, corresponding to a specific activity of > 500 IU/mg.
Recombinant Human GDF6 Protein (rp146383) - SDS-PAGE
Recombinant Human GDF6 Protein was resolved with SDS-PAGE under reducing (R) and visualized by Coomassie? Blue staining, showing a single band at 27.1 kDa.
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