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Recombinant Human CYR61/CCN1 Protein(Active)

功能和特点
  • 规格或纯度: Animal Free, >95%(SDS-PAGE, HPLC), Active, E.coli, No tag, 25-381 aa
  • 生物活性: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/3T3 cells is less than 3.0 μg/ml, corresponding to a specific activity of > 330 IU/mg.
  • 蛋白标签: No tag
  • 应用: Cell Culture,Active
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库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
rp144926-10μg (试用装)
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 		10μg 现货 Stock Image
rp144926-50μg
 50μg 现货 Stock Image
rp144926-100μg
 100μg 现货 Stock Image
rp144926-1mg
 1mg 期货 Stock Image
rp144926-250μg
 250μg 现货 Stock Image
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Accession#:O00622 CCN1 CYR61 Gene ID:3491
main product photo

基本描述

产品名称 Recombinant Human CYR61/CCN1 Protein
规格或纯度 Animal Free, >95%(SDS-PAGE, HPLC), Active, E.coli, No tag, 25-381 aa
产品介绍


Purity
> 95 % by SDS-PAGE and HPLC analyses.

Function
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Banckground:
Cyr61, also known as CCN1, is a 40-45 kDa matricellular glycoprotein that plays an important role in cellular adhesion and migration (1). Cyr61 consists of an IGFBP domain, a VWF type C domain, a TSP type I domain, and a cysteine knot domain (2). Mature human Cyr61 shares 93% amino acid sequence identity with mouse and rat Cyr61. It is widely expressed during development and in adult tissues (2, 3). Cyr61 associates with the extracellular matrix (ECM) and with many cell surface molecules including Integrins alpha V beta 3, alpha V beta 5, alpha M beta 2, and alpha 6 beta 1, Syndecan-4, and heparan sulfate proteoglycans (1, 3). Cyr61 mediates the adhesion and migration of multiple cell types and also promotes vascular endothelial cell tubule formation (4-6). Plasmin cleavage of ECM-bound Cyr61 releases a 28 kDa N-terminal fragment which retains the ability to promote endothelial cell migration (7). Cyr61 exhibits both tumorigenic and tumor suppressor properties. It is up-regulated and promotes tumorigenesis, angiogenesis, and metastasis in breast, renal, gastric, squamous cell, and colorectal carcinomas as well as in glioma (8-12). In contrast, when

down-regulated, it suppresses tumor growth in endometrial, hepatic, and non-small cell lung cancers (8, 13, 14). Cyr61 is also up-regulated in injured skin and bone where it induces the expression of growth factors, cytokines, proteases, and integrins involved in wound repair (15, 16).
生物活性 Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/3T3 cells is less than 3.0 μg/ml, corresponding to a specific activity of > 330 IU/mg.
种属 Human
氨基酸 25-381 aa
序列 TCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSS
纯度 ＞95%(SDS-PAGE, HPLC)
蛋白标签 No tag
蛋白长度 Protein fragment
无载体 Yes
无动物源 Yes
Accession # O00622
来源 Recombinant
预测分子量 39.4 kDa
SDS-PAGE 39.4 kDa

产品规格参数

应用 Cell Culture,Active
物理外观 Lyophilized
储存缓冲液 Lyophilized from a 0.2 μm filtered concentrated solution in citrate buffer solution, 300 mM NaCl, pH 3.0
复溶 We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportio
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconst

图片

Recombinant Human CYR61/CCN1 Protein (rp144926)-Protein Bioactivity
Fully biologically active when compared to standard. The ED???as determined by a cell proliferation assay using murine Balb/3T3 cells is less than 3.0 μg/mL, corresponding to a specific activity of > 330 IU/mg.

Recombinant Human CYR61/CCN1 Protein (rp144926)-SDS-PAGE
Recombinant Human CYR61/CCN1 Protein was resolved with SDS-PAGE under reducing (R) and visualized by Coomassie? Blue staining, showing a single band at 39.4 kDa.

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