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Recombinant Human CCL4L1 Protein(Active)

规格或纯度: Animal Free, >97%(SDS-PAGE, HPLC), Active, E.coli, No tag, 24-92 aa
  • 蛋白长度: Full length protein
  • 蛋白标签: No tag

  • 应用: Cell Culture,Mass Spectrometry,Active,SDS-PAGE
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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
rp143752-10μg 10μg 现货 Stock Image
rp143752-50μg 50μg 现货 Stock Image
rp143752-100μg 100μg 现货 Stock Image
rp143752-1mg 1mg 期货 Stock Image
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基本描述

产品名称 Recombinant Human CCL4L1 Protein
规格或纯度 Animal Free, >97%(SDS-PAGE, HPLC), Active, E.coli, No tag, 24-92 aa
产品介绍


Purity:
>97%(SDS-PAGE, HPLC)

Function：
Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.

Background:
CCL4, also known as MIP-1 beta, is a 12 kDa beta chemokine that is secreted by activated leukocytes, lymphocytes, vascular endothelial cells, and pulmonary smooth muscle cells. CCL4 interacts with CCR5 to attract lymphocytes, NK cells, and immature dendritic cells to sites of inflammation. CCL4 also blocks the entry of HIV into CCR5-expressing cells. Human CCL4 and its variants are encoded by two paralogous genes, one of which (SCYA4) encodes CCL4 itself. The other gene (SCYA4L) is found in two alleles that give rise to CCL4L1 and CCL4L2, respectively. The human CCL4L1 cDNA encodes a 92 amino acid (aa) precursor with a 23 aa signal sequence. Alternate splicing yields an isoform with a 40 aa internal deletion. The second allele (SCYA4L2), encoding CCL4L2, is spliced into a variety of isoforms. Human CC4L1 shares greater than 98% aa sequence identity with CCL4 and CCL4L2. It shares 96% aa sequence identity with rhesus CCL4 and approximately 80 - 90% aa sequence identity with bovine, mouse, rabbit, and rat CCL4. The gene copy number for CCL4L1 varies from zero to five, but this is not associated with changes in mRNA or protein levels. CCL4 and CCL4L1 demonstrate comparable CCR5 binding, promotion of chemotaxis, and inhibition of HIV replication in stimulated PBMC. In vivo, the first two N-terminal amino acids of CCL4 are removed by DPPIV. The truncated form is as active as full-length CCL4 and gains the ability to bind CCR1 and CCR2b. Similar proteolytic processing of CCL4L1 has not been described.
生物活性 Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human CCR5 transfected murine BaF3 cells is less than 2.0 ng/ml, corresponding to a specific activity of > 5.0 × 105 IU/mg.
种属 Human
氨基酸 24-92 aa
序列 APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN
蛋白标签 No tag
蛋白长度 Full length protein
Carrier Free Yes
AnimalFree Yes
Accession# Q8NHW4
来源 Recombinant
预测分子量 7.8 kDa
SDS-PAGE 7.8 kDa

产品规格参数

应用 Cell Culture,Mass Spectrometry,Active,SDS-PAGE
物理外观 Lyophilized
储存缓冲液 Lyophilized from a 0.2 μm filtered concentrated solution in PBS.
复溶 We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 1.0 mg/mL. Stock solutions should be apportioned
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

图片

Recombinant Human CCL4L1 Protein (rp143752)-Protein Bioactivity
Fully biologically active when compared to standard. The ED50?as determined by a cell proliferation assay using human CCR5 transfected murine BaF3 cells is less than 2.0 ng/mL, corresponding to a specific activity of > 5.0 × 10??IU/mg.

Recombinant Human CCL4L1 Protein (rp143752)-SDS-PAGE
Recombinant Human CCL4L1 Protein was resolved with SDS-PAGE under reducing (R) and visualized by Coomassie? Blue staining. Showing a single band at 7.8?kDa.

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