英文名称 | (R)-Equol |
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英文别名 | (+)-Equol; Isoequol |
储存温度 | -20°C储存 |
运输条件 | 超低温冰袋运输 |
产品介绍 |
(R)-Equol是一种非甾体雌激素,由人类肠道菌群代谢异黄酮类植物雌激素黄豆苷元产生。它是一种以两种对映体形式存在的手性分子。与(S)-雌马酚的雌激素受体选择性相反,(R)-雌马酚是一种较弱的ER激动剂,它与ERα和ERβ的K | i |值分别为27.4和15.4 nM。与ERβ相比,(R)-对映体在ERα处表现出更高的ER激动剂活性。 (R)-Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein by human intestinal microflora. It is a chiral molecule that exists in two enantiomeric forms. In contrast to the estrogen receptor selectivity of (S)-equol , (R)-equol is a weaker ER agonist that binds to ERα and ERβ with K|i|values of 27.4 and 15.4 nM, respectively. The (R)-enantiomer demonstrates higher ER agonist activity at ERα compared to ERβ. |
IUPAC Name | (3R)-3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol |
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INCHI | InChI=1S/C15H14O3/c16-13-4-1-10(2-5-13)12-7-11-3-6-14(17)8-15(11)18-9-12/h1-6,8,12,16-17H,7,9H2/t12-/m0/s1 |
InChi Key | ADFCQWZHKCXPAJ-LBPRGKRZSA-N |
Canonical SMILES | C1C(COC2=C1C=CC(=C2)O)C3=CC=C(C=C3)O |
分子式 |
C15H14O3 |
PubChem CID | 6950272 |
分子量 | 242.27 |
溶解性 | Soluble in ethanol (~20 mg/ml), DMSO (~20 mg/ml), DMF (~10 mg/ml), and ethanol : PBS (1:10, pH 7.2) (~0.1 mg/ml). |
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折光率 | n20D1.65 (Predicted) |