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基本描述
| 规格或纯度 | ≥95% SDS-PAGE |
|---|---|
| 英文名称 | Recombinant Human Keratinocyte Growth Factor from Oryza sativa,OsrhKGF |
| 别名 | hKGF；KGF；hFGF-7；FGF-7 |
| 生化机理 | 角质形成细胞生长因子（KGF）可刺激角质形成细胞和其他上皮层中细胞的增殖和分化。它会诱导微血管内皮的细胞趋化以及大鼠角膜的新生血管形成。它可刺激正在发生增殖和迁移的基底细胞进行透明质酸合成。KGF有助于细胞在应激条件下的存活。KGF在受损和发生炎症的上皮细胞中具有高表达，从而促进伤口愈合。 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
产品介绍 KGF角质细胞生长因子（Keratinocyte growth factor，KGF）是Rubin等（1989）从胚胎肺成纤维细胞培养上清中发现的一种细胞因子，为FGF 家族成员，即FGF-7。KGF由间质细胞分泌，受体分布于上皮细胞，是一种有效的上皮细胞特异性生长因子，其有丝分裂活性主要表现在角质形成细胞，可特异性地促进上皮细胞增殖、迁移及分化，与器官发育、创面修复、肿瘤发生及免疫重建等多方面关系密切。 OsrhKGF是运用基因重组技术，由水稻胚乳细胞表达并通过蛋白提纯工艺而成。 规格参数 来源? ? 水稻种子 外观? ? 白色冻干粉 活性? ? ≥1.0×105IU/mg pH值? ?6.5-7.5 分子量? 19.0 kD 内毒素? ≦0.1EU/ug CAS No? 148348-15-6 注意事项 复溶：建议用无菌水重溶OsrhKGF冻干粉至100-200 ug/ml，可用其他溶剂进行进一步稀释。溶解后的OsrhKGF 4℃可保存2-7天，尽快用完。若短期不用，请置于-20℃保存。 开启后，请尽快使用，避免污染。 使用限制 仅适于科研、实验室和生产使用，不能直接使用于人体 Product Introduction KGF keratinocyte growth factor (KGF), a cytokine identified by Rubin et al (1989) from the culture supernatant of embryonic lung fibroblasts, is an FGF family member, namely FGF-7.KGF is secreted by stromal cells and its receptor is distributed in epithelial cells, where it is a potent epithelial cell specific growth factor, and its mitogenic activity is mainly expressed in keratinocytes, which can specifically promote epithelial cell proliferation, migration and differentiation, and is closely related to many aspects, such as organ development, wound repair, tumorigenesis and immune reconstitution. Osrhkgf was created using genetic recombination, expressed from rice endosperm cells and through a protein purification process. Specification parameters Source? ? Oryza sativa Appearance white lyophilized powder Activity? ?≥1.0×105IU/mg pH? ?6.5-7.5 Molecular weight?? 19.0 kD Endotoxin? ≦0.1EU/ug CAS No? 148348-15-6 Matters needing attention Reconstitution: it is recommended to lyophilize the powder of osrhkgf to 100-200 UG/ml with sterile water to make further dilutions with other solvents.The dissolved osrhkgf could be stored for 2-7 days at 4 ? C and used up as soon as possible.To not use for short periods, store at - 20 ℃. Use as soon as possible after opening to avoid contamination. Limitations of use It is suitable for research, laboratory and production use only and cannot be used directly in humans |
产品属性
| pH | 6.5-7.5 |
|---|
名称和标识符
| 分子式 |
|
|---|---|
| 分子量 | 19.0 kD |
安全信息
| WGK Germany | 3 |
|---|
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产品问答
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