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聚（乙二醇）-嵌段-聚乙烯亚胺
规格或纯度:
PEG M? 750, PEI M? 15k
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基本描述
| 规格或纯度 | PEG M? 750, PEI M? 15k |
|---|---|
| 英文名称 | Poly(ethylene glycol)-block-polyethyleneimine |
| 英文别名 | Linear poly(ethylene glycol)-block-polyethylenimine, PEG-b-PEI, PEG-PEI |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
Description Gene therapy using polymeric nonviral vectors promises considerable advances in the treatment of many genetic and acquired diseases due to the carrier safety and low immunogenicity profiles. Poly(ethyleneimine) is one of the most commonly used cationic polymers for gene delivery applications. Copolymers of PEI and hydrophilic poly(ethylene glycol) have been designed to provide a stealth-like shield around polymer/DNA complexes, reducing nonspecific interactions, inhibiting activation of the reticuloendothelial system, and prolonging the half-life of the complexes in the blood. Description Gene therapy using polymeric nonviral vectors promises considerable advances in the treatment of many genetic and acquired diseases due to the carrier safety and low immunogenicity profiles. Poly(ethyleneimine) is one of the most commonly used cationic polymers for gene delivery applications. Copolymers of PEI and hydrophilic poly(ethylene glycol) have been designed to provide a stealth-like shield around polymer/DNA complexes, reducing nonspecific interactions, inhibiting activation of the reticuloendothelial system, and prolonging the half-life of the complexes in the blood. |
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参考文献
| 1. Pallab Banerjee, Ralph Weissleder, Alexei Bogdanov,. (2006-01-19) Linear polyethyleneimine grafted to a hyperbranched poly(ethylene glycol)-like core: a copolymer for gene delivery.. Bioconjugate chemistry, 17 ((1)): ( 125-131 ). [PMID:16417260] |
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