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匹伐他汀钙

强大的HMG-CoA还原酶竞争性抑制剂

规格或纯度: ≥99%

CAS编号: 147526-32-7
分子式: C₅₀H₄₆CaF₂N₂O₈
分子量: 880.98
PubChem编号: 5282451

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货号 (SKU)	包装规格	是否现货	价格	数量
P129617-10mg	10mg	现货
P129617-50mg	50mg	现货
P129617-250mg	250mg	现货
P129617-1g	1g	现货

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基本描述

规格或纯度	≥99%
英文名称	Pitavastatin Calcium
别名	匹伐他汀钙
英文别名	Pitavastatin hemicalcium; Nisvastatin;(+)-Monocalcium bis{(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoate}
生化机理	Pitavastatin Calcium 是一种新型的Statins类药物。Potent, competitive inhibitor of HMG-CoA reductase (K i = 1.7nM). Blocks cholesterol synthesis. Displays cardioprotective properties. Orally active.
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting NADPH oxidase. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187. Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells.A competitive inhibitor of HMG-CoA reductase Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting NADPH oxidase. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187. Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells. A competitive inhibitor of HMG-CoA reductase

名称和标识符

IUPAC Name	calcium;(E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate
INCHI	InChI=1S/2C25H24FNO4.Ca/c226-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31;/h21-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31);/q;;+2/p-2/b212-11+;/t218-,19-;/m11./s1
InChi Key	RHGYHLPFVJEAOC-FFNUKLMVSA-L
Canonical SMILES	C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.[Ca+2]
分子式	C₅₀H₄₆CaF₂N₂O₈
关联CAS	147511-69-1
PubChem CID	5282451
分子量	880.98

化学和物理性质

溶解性	DMSO 51 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

安全信息

象形图	Health Hazard
信号词	Warning
危险声明	H361f: Suspected of damaging fertility
预防措施声明	P280,P405,P501,P201,P308+P313,P202

参考文献

1. Montonye ML et al.. (2019) A Pharmacokinetic Natural Product-Disease-Drug Interaction: A Double Hit of Silymarin and Nonalcoholic Steatohepatitis on Hepatic Transporters in a Rat Model.. J Pharmacol Exp Ther, 371 (2): (385-393). [PMID:31420525]
2. Pa?keviciute M & Petrikaite V. (2017) Differences of statin activity in 2D and 3D pancreatic cancer cell cultures.. Drug Des Devel Ther, 11 (): (3273-3280). [PMID:29180851]
3. Kolawole EM et al.. (2016) Fluvastatin Suppresses Mast Cell and Basophil IgE Responses: Genotype-Dependent Effects.. J Immunol, 196 (4): (1461-70). [PMID:26773154]
4. Lynch KD et al.. (2021) Hepatic organic anion transporting polypeptides mediate disposition of milk thistle flavonolignans and pharmacokinetic silymarin-drug interactions.. Phytother Res, 35 (6): (3286-3297). [PMID:33587330]
5. Liu H et al.. (2017) Pitavastatin nanoparticle-engineered endothelial progenitor cells repair injured vessels.. Sci Rep, 7 (): (18067). [PMID:29273744]

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