Cas(1405-20-5), 硫酸多粘菌素B-阿拉丁试剂, 多粘菌素B硫酸盐,Polymyxin B sulfate,

货号 (SKU)	包装规格	是否现货
P105490-1g	1g	现货
P105490-5g	5g	现货
P105490-25g	25g	现货

基本描述

规格或纯度	USP级,≥6,000 USP units/mg
英文名称	Polymyxin B sulfate
别名	多粘菌素B硫酸盐
英文别名	Polymyxin B sulfate salt;Aerosporin;Mastimyxin
生化机理	Polymyxin B is one of the most important antibiotics used to treat gram-negative bacterial infections, including infections caused by carbapenem-resistant non-fermenters and carbapenem-resistant Enterobacteriaceae. Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides?, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.Cationic surfactant antibiotic agent. Mixture of polymyxins B1 and B2. Increases the permeability of the cell membrane. Shows bactericidal effects against Gram-negative bacteria in vivo.
储存温度	2-8°C储存,避光
运输条件	冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，这些产品最多可以使用一周。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	易溶于40％的乙醇水溶液中，溶于水。在醚、酮、酯、烃等有机溶剂中几乎不溶解。多粘菌素B为抗革兰阴性杆菌多肽类抗生素, 可以改变膜结构使小分子物质泄漏而抑制革兰氏阴性菌的生长。对大肠杆菌具有杀菌作用。结合到细菌脂多糖类的脂质A部分。在外皮细胞膜诱发小孔。作用模式: 结合并干涉细胞质膜的渗透性。抗菌谱: 革兰式阴性细菌。 Chemical structure: peptide Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa?. It also has uses studying multidrug-resistant pathogens??, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots. Polymyxin B sulfate salt has been used: ???in human aortic endothelial cells (HAEC) cell culture to exclude potential endotoxin contamination in recombinant adiponectin ???in the analysis of the isolates ???in endotoxin-neutralizing activity of α-amylase (AmyI-1)-18 (LAL assay)

名称和标识符

IUPAC Name	N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acid
INCHI	InChI=1S/C56H98N16O13.H2O4S/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79;1-5(2,3)4/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80);(H2,1,2,3,4)
InChi Key	HFMDLUQUEXNBOP-UHFFFAOYSA-N
Canonical SMILES	CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O
分子式	C₅₆H₁₀₀N₁₆O₁₇S
PubChem CID	5702105
分子量	1301.6

化学和物理性质

溶解性	Soluble in water at 50mg/ml/n
敏感性	对光、热、湿度敏感
比旋光度	-80 ° (C=2, H2O)

安全信息

象形图	Harmful
信号词	Warning
危险声明	H302: Harmful if swallowed
预防措施声明	P501,P264,P270,P330,P301+P317
RTECS	TR1150000
Merck Index	7573
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

参考文献

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硫酸多粘菌素B

库存信息

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基本描述

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化学和物理性质

安全信息

参考文献

相关文档

质检报告COA

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