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NCX-4016

CAS编号: 175033-36-0
分子式: C₁₆H₁₃NO₇
分子量: 331.28
PubChem编号: 119032

有货

库存信息

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库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
N612194-5mg	5mg	期货
N612194-25mg	25mg	期货

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基本描述

英文名称	NCX-4016
别名	NCX 4016;NCX4016;nitric oxide-releasing aspirin;nitroaspirin
英文别名	NCX 4016;NCX4016;nitric oxide-releasing aspirin;nitroaspirin

名称和标识符

IUPAC Name	[3-(nitrooxymethyl)phenyl] 2-acetyloxybenzoate
INCHI	InChI=1S/C16H13NO7/c1-11(18)23-15-8-3-2-7-14(15)16(19)24-13-6-4-5-12(9-13)10-22-17(20)21/h2-9H,10H2,1H3
InChi Key	IOJUJUOXKXMJNF-UHFFFAOYSA-N
Canonical SMILES	CC(=O)OC1=CC=CC=C1C(=O)OC2=CC=CC(=C2)CO[N+](=O)[O-]
PubChem CID	119032
分子量	331.28

数据库链接

PubChem CID	119032
Wikipedia	Nitroaspirin
CAS Registry No.	175033-36-0
ChEMBL Ligand	CHEMBL374385

化学和物理性质

熔点	61-62° C

关联配体

Ligand ID	9018
名称	NCX-4016
别名	nitric oxide-releasing aspirin
类别	Synthetic organic
学名	[3-(nitrooxymethyl)phenyl] 2-acetyloxybenzoate
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	NCX-4016 is an inhibitor which supports generation of reactive oxygen species (ROS) that modify CCL2 levels, disabling T cell chemotaxis. It is expected that this type of action will have anti-inflammatory, antiproliferative, and cytoprotective activity . NCX-4016 is a NO-NSAID type compound (nitric oxide-donating NSAID), a hybrid nitrate conjugated to an NSAID, in this case . This type of compound was designed to exploit the gastroprotective properties of NO bioactivity, to combat the gastrotoxicity which compromises NSAID use .
配体家族	Non-steroidal anti-inflammatory ligands

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参考文献

1. Rao CV, Reddy BS, Steele VE, Wang CX, Liu X, Ouyang N, Patlolla JM, Simi B, Kopelovich L, Rigas B. (2006) Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets.. Mol Cancer Ther, 5 (6): (1530-8). [PMID:16818512]
2. Hagos GK, Abdul-Hay SO, Sohn J, Edirisinghe PD, Chandrasena RE, Wang Z, Li Q, Thatcher GR. (2008) Anti-inflammatory, antiproliferative, and cytoprotective activity of NO chimera nitrates of use in cancer chemoprevention.. Mol Pharmacol, 74 (5): (1381-91). [PMID:18676677]

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