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1-苯基双胍盐酸盐

5-HT3激动剂
规格或纯度: 97%
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货号 (SKU) 包装规格 是否现货 价格 数量
N193912-250mg 250mg 现货 Stock Image
N193912-1g 1g 现货 Stock Image
N193912-5g 5g 现货 Stock Image
N193912-25g 25g 现货 Stock Image
N193912-100g 100g 现货 Stock Image
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5-HT3A Agonist 5-HT3AB Agonist
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基本描述

规格或纯度 97%
英文名称 N-Phenylimidodicarbonimidic diamide hydrochloride
别名 1-Phenylbiguanide hydrochloride
英文别名 1-Phenylbiguanide hydrochloride
生化机理 5-HT 3受体激动剂。
储存温度 2-8°C储存
运输条件 冰袋运输

名称和标识符

IUPAC Name 1-(diaminomethylidene)-2-phenylguanidine;hydrochloride
INCHI InChI=1S/C8H11N5.ClH/c9-7(10)13-8(11)12-6-4-2-1-3-5-6;/h1-5H,(H6,9,10,11,12,13);1H
InChi Key FHUDRDSKZQDCBC-UHFFFAOYSA-N
Canonical SMILES C1=CC=C(C=C1)N=C(N)N=C(N)N.Cl
分子式

C8H12ClN5
PubChem CID 5932
分子量 213.67

化学和物理性质

溶解性 溶于DMSO, 最高浓度 (mg/mL): 5.34, 最高浓度(mM): 25
熔点 244-247 °C

安全信息

象形图
ghs07

Harmful
信号词 Warning
危险声明 H302: Harmful if swallowed
预防措施声明 P501,P264,P270,P330,P301+P317
WGK Germany 3
RTECS DU2550000
个人防护装备 Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

靶标

Target ID 378
名称 5-HT3AB
缩写名 SHP2
家族 5-HT3 receptors
Target ID 379
名称 5-HT3A
缩写名 SHP2
家族 5-HT3 receptors

关联配体

Ligand ID 2284
名称 1-phenylbiguanide
类别 Synthetic organic
学名 1-(diaminomethylidene)-2-phenylguanidine
生物活性评价 The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价 Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth.

参考文献

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2. Y L Kuo,C J Lai.  (2008-06-07)  Ovalbumin sensitizes vagal pulmonary C-fiber afferents in Brown Norway rats..  Journal of applied physiology (Bethesda, Md. : 1985),  105  ((2)):  (611-620).  [PMID:18535139]
3. Sadhana Kanoo,Shripad B Deshpande.  (2008-06-24)  Involvement of phospholipase A2 pathway for the Indian red scorpion venom-induced augmentation of cardiopulmonary reflexes elicited by phenyldiguanide..  Neuroscience letters,  440  ((3)):  (242-245).  [PMID:18571849]
4. David J Majewski,Liana M Wiegel,Stephen M Johnson.  (2008-09-09)  Respiratory pattern in midline-lesioned brainstems and hemibrainstems from adult turtles..  Respiratory physiology & neurobiology,  164  ((3)):  (338-349).  [PMID:18775518]
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7. S Kanoo,A B Alex,A K Tiwari,S B Deshpande.  (2009-01-13)  B(2) kinin receptors mediate the Indian red scorpion venom-induced augmentation of visceral reflexes via the nitric oxide cyclic guanosine monophosphate pathway..  Acta physiologica (Oxford, England),  196  ((4)):  (365-373).  [PMID:19133874]
8. Florence Netzer,Nathalie Mandjee,Anthony J Verberne,Jean-Fran?ois Bernard,Michel Hamon,Raul Laguzzi,Caroline Sévoz-Couche.  (2009-05-21)  Inhibition of the bradycardic component of the von Bezold-Jarisch reflex and carotid chemoreceptor reflex by periaqueductal gray stimulation: involvement of medullary receptors..  The European journal of neuroscience,  29  ((10)):  (2017-2028).  [PMID:19453625]
9. Michelle E Bartman,Julia E R Wilkerson,Stephen M Johnson.  (2010-04-20)  5-HT3 receptor-dependent modulation of respiratory burst frequency, regularity, and episodicity in isolated adult turtle brainstems..  Respiratory physiology & neurobiology,  172  ((1-2)):  (42-52).  [PMID:20399913]
10. Abhaya Dutta,Shripad B Deshpande.  (2010-11-30)  Indian red scorpion venom-induced augmentation of cardio-respiratory reflexes and pulmonary edema involve the release of histamine..  Toxicon : official journal of the International Society on Toxinology,  57  ((2)):  (193-198).  [PMID:21112349]
11. H A Futuro Neto,S M Macedo,N F Silva,A M Cabral,J G P Pires.  (2011-02-24)  Central 5-HT(2A) receptors modulate the vagal bradycardia in response to activation of the von Bezold-Jarisch reflex in anesthetized rats..  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,  44  ((3)):  (224-228).  [PMID:21344136]
12. John Eme,James W Hicks,Dane A Crossley.  (2011-03-30)  Chronic hypoxic incubation blunts a cardiovascular reflex loop in embryonic American alligator (Alligator mississippiensis)..  Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology,  181  ((7)):  (981-990).  [PMID:21445563]
13. Colleen J Thomas,Atul D Sharma,Robyn L Woods.  (2011-04-15)  Do prostanoids or nitric oxide mediate sensitization of the von Bezold-Jarisch reflex by B-type natriuretic peptide?.  Clinical and experimental pharmacology & physiology,  38  ((7)):  (410-415).  [PMID:21488938]
14. Vanessa Moraes Bezerra,Carlos Henrique Xavier,Rodrigo Cunha Alvim de Menezes,Marco Ant?nio Peliky Fontes,Leonardo Máximo Cardoso,Luciano Gon?alves Fernandes,Deoclécio Alves Chianca.  (2011-05-04)  Bezold-Jarisch reflex in sino-aortic denervated malnourished rats..  Autonomic neuroscience : basic & clinical,  162  ((1-2)):  (48-53).  [PMID:21536501]
15. Stephanie C Tjen-A-Looi,Peng Li,Min Li,John C Longhurst.  (2011-12-30)  Modulation of cardiopulmonary depressor reflex in nucleus ambiguus by electroacupuncture: roles of opioids and γ-aminobutyric acid..  American journal of physiology. Regulatory, integrative and comparative physiology,  302  ((7)):  (R833-R844).  [PMID:22204951]
16. José Raul Cisternas,Vitor E Valenti,Monica A Sato,Fernando L A Fonseca,Paulo H N Saldiva,Carlos B De Mello Monteiro,Modesto Leite Rolim Neto,Luciano M R Rodrigues,Luiz Carlos De Abreu.  (2012-01-21)  The effects of catalase inhibition into the fourth cerebral ventricle on the Bezold-Jarisch reflex in spontaneously hypertensive rats..  Journal of integrative neuroscience,  10  ((4)):  (475-487).  [PMID:22262536]
17. Abhaya Dutta,Aparna Akella,Shripad B Deshpande.  (2012-07-24)  Mechanisms underlying the augmentation of phenylbiguanide and capsaicin induced cardiorespiratory reflexes by Mesobuthus tamulus venom..  Pulmonary pharmacology & therapeutics,  25  ((5)):  (383-391).  [PMID:22820164]
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19. Bashair M Mussa,Daniela M Sartor,Anthony J M Verberne.  (2008-11-26)  Activation of cholecystokinin (CCK 1) and serotonin (5-HT 3) receptors increases the discharge of pancreatic vagal afferents..  European journal of pharmacology,  601  ((1-3)):  (198-206).  [PMID:19026634]
20. Ramin Ataee,Soheila Ajdary,Mehdi Rezayat,Mohammad Ali Shokrgozar,Shadab Shahriari,Mohammad Reza Zarrindast.  (2010-03-02)  Study of 5HT3 and HT4 receptor expression in HT29 cell line and human colon adenocarcinoma tissues..  Archives of Iranian medicine,  13  ((2)):  (120-125).  [PMID:20187666]
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