91高清自产国产拍,无码免费A级毛片大全,日本 欧美 国产中文字幕,99re热视频这里只有精品视频首页

2-硝基咪唑

大环内酯类抗生素剂。低氧标记剂。
规格或纯度: 98%
有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
N119956-100mg
100mg 现货 Stock Image
N119956-250mg
250mg 现货 Stock Image
N119956-1g
1g 现货 Stock Image
N119956-5g
5g 现货 Stock Image
N119956-10g
10g 现货 Stock Image
N119956-25g
25g 现货 Stock Image
查看相关系列
五元杂环化合物 咪唑类

基本描述

规格或纯度 98%
英文名称 2-Nitroimidazole
别名 吖素,氮霉素
英文别名 2-Nitroimidazole|527-73-1|Azomycin|2-NITRO-1H-IMIDAZOLE|nitroimidazole|Amicin|1H-Imidazole, 2-nitro-|Imidazole, 2-nitro-|Ro 05-9129|36877-68-6|MFCD00005185|Azomycin (2-Nitroimidazole)|K8E96XL55D|CHEBI:67135|NSC105831|NSC-105831|Nitroimidazoles|EINECS 208-
生化机理 大环内酯类抗生素剂。低氧标记剂。选择性地在缺氧细胞中积累。抑制细菌蛋白质的合成。在体内对革兰氏阳性,革兰氏阴性细菌和厌氧菌具有杀菌作用。
应用 用于制备硝基咪唑取代的硼酸,从而作为缺氧组织成像前体。还用于制备富含雌激素受体的肿瘤的可用位点选择性放射增敏剂。
运输条件 常规运输
备注 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。
产品介绍

2-Nitroimidazole is a natural antibiotic.用于制备硝基咪唑取代的硼酸,从而作为缺氧组织成像前体。还用于制备富含雌激素受体的肿瘤的可用位点选择性放射增敏剂。

2-Nitroimidazole is a natural antibiotic.
Used to prepare nitroimidazole substituted boronic acids as precursors for imaging hypoxic tissue. Also used to prepare potential site-selective radiosensitizers for estrogen receptor-rich tumors.

名称和标识符

EC号 208-425-5
IUPAC Name 2-nitro-1H-imidazole
INCHI InChI=1S/C3H3N3O2/c7-6(8)3-4-1-2-5-3/h1-2H,(H,4,5)
InChi Key YZEUHQHUFTYLPH-UHFFFAOYSA-N
Canonical SMILES C1=CN=C(N1)[N+](=O)[O-]
WGK Germany 3
RTECS NI7875000
PubChem CID 10701
UN Number 2811
Packing Group III
分子量 113.07
Beilstein号 116444

化学和物理性质

溶解性 NH4OH: soluble 50 mg/mL, clear, yellow to orange
熔点 287°C

安全和危险性(GHS)

象形图
ghs07

Harmful

信号词 Warning
危险声明 H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
预防措施声明 P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319
WGK Germany 3
RTECS NI7875000
Class 3
Merck Index 921
个人防护装备 dust mask type N95 (US), Eyeshields, Faceshields, Gloves

相关文档

质检报告COA

请输入批号:


产品问答

产品问答

登录提交问题 Hover me 请先登录再提交问题
您提交该产品问题后,我们会在1-2个工作日内给您答复,您可以登录"我的账号",然后点击"我的产品问答"查看答案

参考文献

1. M E Watts,M F Dennis,I J Roberts.  (1990-02-01)  Radiosensitization by misonidazole, pimonidazole and azomycin and intracellular uptake in human tumour cell lines..  International journal of radiation biology,  57  ((2)):  (361-372).  [PMID:1968500]
2. M E Watts,N R Jones.  (1985-06-01)  The effect of extracellular pH on radiosensitization by misonidazole and acidic or basic analogues..  International journal of radiation biology and related studies in physics, chemistry, and medicine,  47  ((6)):  (645-653).  [PMID:3873434]
3. A M Rauth,R A McClelland,H B Michaels,R Battistella.  (1984-08-01)  The oxygen dependence of the reduction of nitroimidazoles in a radiolytic model system..  International journal of radiation oncology, biology, physics,  10  ((8)):  (1323-1326).  [PMID:6236187]
4. M V Williams,J Denekamp,A I Minchinton,M R Stratford.  (1982-07-01)  In vivo assessment of basic 2-nitroimidazole radiosensitizers..  British journal of cancer,  46  ((1)):  (127-137).  [PMID:7104192]
5. R V Iyer,E Kim,R F Schneider,J D Chapman.  (1998-07-31)  A dual hypoxic marker technique for measuring oxygenation change within individual tumors..  British journal of cancer,  78  ((2)):  (163-169).  [PMID:9683288]
6. M Shimamura,H Nagasawa,H Ashino,Y Yamamoto,T Hazato,Y Uto,H Hori,S Inayama.  (2003-03-01)  A novel hypoxia-dependent 2-nitroimidazole KIN-841 inhibits tumour-specific angiogenesis by blocking production of angiogenic factors..  British journal of cancer,  88  ((2)):  (307-313).  [PMID:12610518]
7. Piyush Kumar,Saeed Emami,Alexander J B McEwan,Leonard I Wiebe.  (2008-05-16)  Stereospecific deuteration of alpha-furanosyl azomycin nucleosides: a model reaction for tritium radiolabeling..  Bioorganic & medicinal chemistry letters,  18  ((11)):  (3256-3260).  [PMID:18479915]
8. P Kumar,S Emami,Z Kresolek,J Yang,A J B McEwan,L I Wiebe.  (2009-03-12)  Synthesis and hypoxia selective radiosensitization potential of beta-2-FAZA and beta-3-FAZL: fluorinated azomycin beta-nucleosides..  Medicinal chemistry (Shariqah (United Arab Emirates)),  ((2)):  (118-129).  [PMID:19275710]
9. Yi Qu,Jim C Spain.  (2011-01-20)  Catabolic pathway for 2-nitroimidazole involves a novel nitrohydrolase that also confers drug resistance..  Environmental microbiology,  13  ((4)):  (1010-1017).  [PMID:21244596]
10. Zhihao Zha,Lin Zhu,Yajing Liu,Fenghua Du,Hongmei Gan,Jinping Qiao,Hank F Kung.  (2011-05-03)  Synthesis and evaluation of two novel 2-nitroimidazole derivatives as potential PET radioligands for tumor imaging..  Nuclear medicine and biology,  38  ((4)):  (501-508).  [PMID:21531287]
11. Melinda Wuest,Piyush Kumar,Monica Wang,Jennifer Yang,Hans-Soenke Jans,Leonard I Wiebe.  (2012-07-04)  In vitro and in vivo evaluation of [(18)F]F-GAZ, a novel oxygen-mimetic azomycin-glucose conjugate, for imaging hypoxic tumor..  Cancer biotherapy & radiopharmaceuticals,  27  ((8)):  (473-480).  [PMID:22746267]
12. Madhava B Mallia,Anupam Mathur,Haladhar D Sarma,Sharmila Banerjee.  (2015-01-09)  A (99m)Tc-labeled misonidazole analogue: step toward a (99m)Tc-alternative to [18F]fluromisonidazole for detecting tumor hypoxia..  Cancer biotherapy & radiopharmaceuticals,  30  ((2)):  (79-86).  [PMID:25569675]
13. Erina Hanaki,Mikayo Hayashi,Makoto Matsumoto.  (2016-12-19)  Delamanid is not metabolized by Salmonella or human nitroreductases: A possible mechanism for the lack of mutagenicity..  Regulatory toxicology and pharmacology : RTP,  84  ():  (1-8).  [PMID:27988333]
14. Tatiana Rodrigues Alexandre,Marta Lopes Lima,Mariana Kolos Galuppo,Juliana Tonini Mesquita,Matilia Ana do Nascimento,Augusto Leonardo Dos Santos,Patricia Sartorelli,Daniel Carvalho Pimenta,Andre Gustavo Tempone.  (2017-06-03)  Ergosterol isolated from the basidiomycete.  The journal of venomous animals and toxins including tropical diseases,  23  ():  (30-30).  [PMID:28572816]
15. Christin Glowa,Peter Peschke,Stephan Brons,Oliver C Neels,Klaus Kopka,Jürgen Debus,Christian P Karger.  (2017-11-11)  Carbon ion radiotherapy: impact of tumor differentiation on local control in experimental prostate carcinomas..  Radiation oncology (London, England),  12  ((1)):  (174-174).  [PMID:29121984]
16. Cameron J Koch.  (2018-05-11)  A Two-Component Assay for Hypoxia Incorporating Long-Term Nitroreduction and Short-Term DNA-Damage Allows Differentiation of the Three Hypoxia Sub-types..  Radiation research,  190  ((1)):  (72-87).  [PMID:29746214]
17. Xiulong Shen,Kent S Gates.  (2019-03-01)  Enzyme-Activated Generation of Reactive Oxygen Species from Heterocyclic N-Oxides under Aerobic and Anaerobic Conditions and Its Relevance to Hypoxia-Selective Prodrugs..  Chemical research in toxicology,  32  ((3)):  (348-361).  [PMID:30817135]
18. R K Jackson,L P Liew,M P Hay.  (2019-03-12)  Overcoming Radioresistance: Small Molecule Radiosensitisers and Hypoxia-activated Prodrugs..  Clinical oncology (Royal College of Radiologists (Great Britain)),  31  ((5)):  (290-302).  [PMID:30853148]
19. Ingrid Rosenburg Cordeiro,Kaori Kabashima,Haruki Ochi,Keijiro Munakata,Chika Nishimori,Mara Laslo,James Hanken,Mikiko Tanaka.  (2019-06-18)  Environmental Oxygen Exposure Allows for the Evolution of Interdigital Cell Death in Limb Patterning..  Developmental cell,  50  ((2)):  (155-166).  [PMID:31204171]
20. Mónica Mendes, Gustavo García, Marie-Christine Bacchus-Montabonel, Paulo Lim?o-Vieira,.  ( 2019-12-11)  Electron Transfer Induced Decomposition in Potassium-Nitroimidazoles Collisions: An Experimental and Theoretical Work..  International journal of molecular sciences,  20  ((24)):  ().  [PMID:31817793]
21. Azhar Rashid,Sohaib H Mazhar,Qiaoting Zeng,Claude Kiki,Chang-Ping Yu,Qian Sun.  (2020-04-20)  Simultaneous analysis of multiclass antibiotic residues in complex environmental matrices by liquid chromatography with tandem quadrupole mass spectrometry..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  1145  ():  (122103-122103).  [PMID:32305705]
22. Akihiro Kaneko,Tetsuya Matsumoto,Hiroshi Iwabuchi,Junko Sato,Tomotaro Wakamura,Hiroshi Kiyota,Kazuhiro Tateda,Hideaki Hanaki,Noriyuki Sakakibara,Takayuki Mizuno,Hisashi Miyajima,Hiroyuki Naito,Ritsuo Takagi,Yasumitsu Kodama,Akira Yamaguchi,Ryo Akasiba,Nobuo Yamane,Yoshinori Jinbu,Mikio Kusama,Norito Miyagi,Reiko Kato,Noriko Nakatogawa,Kazumi Izawa,Hideki Tanzawa,Yoshinao Kozu,Hideki Watanabe,Koichi Matsumoto,Takahiko Shibahara,Yasunobu Busujima,Tsuyoshi Takato,Haruo Sakamoto,Daisuke Watanabe,Hiroyuki Kubota,Jiro Sasaki,Masataka Uematsu,Masashi Sasaki,Atsuo Kaetsu,Fumitaka Terasawa,Yoshiaki Yura,Soichi Iwai,Shosuke Morita,Kazuhiro Matsumoto,Tetsuo Oonishi,Takahide Komori,Shungo Furudoi,Junko Fujibayashi,Masahiro Urade,Hiromitsu Kishimoto,Takashi Yoshii,Takefumi Morihana,Daisuke Miyai,Tetsuji Okamoto,Taku Kanda,Kosei Okamoto,Akihiko Sakamoto,Yoshiro Matsui,Minoru Miyake,Takashi Sawai,Tetsuro Ikebe,Kenichiro Hashimoto.  (2020-06-28)  Antimicrobial susceptibility surveillance of bacterial isolates recovered in Japan from odontogenic infections in 2013..  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy,  26  ((9)):  (882-889).  [PMID:32591324]
23. Jana, et al..  (2020)  Synthetic enzyme-based nanoparticles act as smart catalyst for glucose responsive release of insulin..  Journal of Biotechnology,  324  ():  (1-6).  [PMID:32987063]
24. J H Shoji,H Hinoo,Y Terui,J Kikuchi,T Hattori,K Ishii,K Matsumoto,T Yoshida.  (1989-10-01)  Isolation of azomycin from Pseudomonas fluorescens..  The Journal of antibiotics,  42  ((10)):  (1513-1514).  [PMID:2509407]
25. A I Minchinton,M R Stratford.  (1986-07-01)  A comparison of tumor and normal tissue levels of acidic, basic and neutral 2-nitroimidazole radiosensitizers in mice..  International journal of radiation oncology, biology, physics,  12  ((7)):  (1117-1120).  [PMID:2943710]
26. M F Dennis,M R Stratford,P Wardman,M E Watts.  (1985-06-01)  Cellular uptake of misonidazole and analogues with acidic or basic functions..  International journal of radiation biology and related studies in physics, chemistry, and medicine,  47  ((6)):  (629-643).  [PMID:3873433]
27. H Ide,O Ohkubo,A Sakamoto,S Nishimoto,T Wada,T Kagiya.  (1984-09-01)  Radiation-induced oxidative denitration of 2-nitroimidazoles in aqueous solution..  Journal of radiation research,  25  ((3)):  (246-250).  [PMID:6512746]
28. N M Najib,N Idkaidek,I E Ghanem,I Admour,S Mahmood Alam,Q Zaman,R Dham.  (2001-12-18)  Bioequivalence assessment of Azomycin (Julphar, UAE) as compared to Zithromax (Pfizer, USA)--two brands of azithromycin--in healthy human volunteers..  Biopharmaceutics & drug disposition,  22  ((1)):  (15-21).  [PMID:11745903]
29. Edward L Engelhardt,Richard F Schneider,Steven H Seeholzer,Corinne C Stobbe,J Donald Chapman.  (2002-06-07)  The synthesis and radiolabeling of 2-nitroimidazole derivatives of cyclam and their preclinical evaluation as positive markers of tumor hypoxia..  Journal of nuclear medicine : official publication, Society of Nuclear Medicine,  43  ((6)):  (837-850).  [PMID:12050331]
30. Piyush Kumar,Leonard I Wiebe,Rezaul H Mannan,Zaihui Zhang,Haiyan Xia,Alexander J B McEwan.  (2002-11-16)  [99mTc]Technetium labelled PnAo-azomycin glucuronides: a novel class of imaging markers of tissue hypoxia..  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,  57  ((5)):  (719-728).  [PMID:12433047]
31. David Leitsch,Daniel Kolarich,Iain B H Wilson,Friedrich Altmann,Michael Duchêne.  (2007-08-07)  Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase..  PLoS biology,  ((8)):  (e211-e211).  [PMID:17676992]
32. Stephan Harm,Anna Gruber,Franz Gabor,Jens Hartmann.  (2015-10-22)  Adsorption of Selected Antibiotics to Resins in Extracorporeal Blood Purification..  Blood purification,  41  ((1-3)):  (55-63).  [PMID:26488754]
33. Petra Kri?ková,Anna Wieczorek,Friedrich Hammerschmidt.  (2017-01-28)  Efficient preparation of 2-nitroimidazole nucleosides as precursors for hypoxia PET tracers..  Monatshefte fur chemie,  148  ((1)):  (83-90).  [PMID:28127094]
34. Kazuki Yoshihara,Kohei Takagi,Aoi Son,Ryohsuke Kurihara,Kazuhito Tanabe.  (2017-05-16)  Aggregate Formation of Oligonucleotides that Assist Molecular Imaging for Tracking of the Oxygen Status in Tumor Tissue..  Chembiochem : a European journal of chemical biology,  18  ((16)):  (1650-1658).  [PMID:28503897]
35. Chioma G Anusionwu,Blessing A Aderibigbe,Xavier Y Mbianda.  (2018-12-12)  Hybrid Molecules Development: A Versatile Landscape for the Control of Antifungal Drug Resistance: A Review..  Mini reviews in medicinal chemistry,  19  ((6)):  (450-464).  [PMID:30526457]
36. Bryce E Kidd,Jonathan L Gesiorski,Max E Gemeinhardt,Roman V Shchepin,Kirill V Kovtunov,Igor V Koptyug,Eduard Y Chekmenev,Boyd M Goodson.  (2018-12-19)  Facile Removal of Homogeneous SABRE Catalysts for Purifying Hyperpolarized Metronidazole, a Potential Hypoxia Sensor..  The journal of physical chemistry. C, Nanomaterials and interfaces,  122  ((29)):  (16848-16852).  [PMID:30559921]
37. Sandra Mendoza-Elizalde,Ana Caren Cortés-Márquez,Gerardo Zu?iga,René Cerritos,Pedro Valencia-Mayoral,Alejandra Consuelo Sánchez,Hector Olivares-Clavijo,Norma Velázquez-Guadarrama.  (2019-08-10)  Inference from the analysis of genetic structure of Helicobacter pylori strains isolates from two paediatric patients with recurrent infection..  BMC microbiology,  19  ((1)):  (184-184).  [PMID:31395006]
38. Keonte J Graves,Jan Novak,W Evan Secor,Patricia J Kissinger,Jane R Schwebke,Christina A Muzny.  (2020-07-31)  A systematic review of the literature on mechanisms of 5-nitroimidazole resistance in Trichomonas vaginalis..  Parasitology,  147  ((13)):  (1383-1391).  [PMID:32729451]
39. Zhang, et al..  (2020)  Hypoxia-responsive nanogel as IL-12 carrier for anti-cancer therapy..  Nanotechnology,  32  ():  (095107-095107).  [PMID:33238258]

91高清自产国产拍,无码免费A级毛片大全,日本 欧美 国产中文字幕,99re热视频这里只有精品视频首页

品牌简介

{转码主词}