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甲基丙烯酰化海藻酸钠（AlgMA）
规格或纯度:
MA化程度20%-30%，分子量约50KDa
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基本描述
| 规格或纯度 | MA化程度20%-30%，分子量约50KDa | |||||
|---|---|---|---|---|---|---|
| 英文名称 | Methacrylated Alginate | |||||
| 别名 | ALMA | |||||
| 英文别名 | ALMA | |||||
| 储存温度 | 避光,-20°C储存 | |||||
| 运输条件 | 超低温冰袋运输 | |||||
| 产品介绍 |
产品介绍： 甲基丙烯酰化海藻酸钠（AlgMA）是通过在海藻酸钠分子链上引入甲基丙烯基团进而赋予其光固化能力。相比传统二价离子（钙离子等）交联，光固化交联方式便携化高，且凝胶内部均一性良好。基于AlgMA的材料体系已被广泛应用于许多生物医药研究领域，包括：肿瘤模型构建、细胞负载、创面敷料、药物控释、齿科印模等。此外，海藻酸钠结构单元中的-OH和-COOH均可以作为化学活性位点，通过化学改性引入更多的活性基团，从而赋予其新的性能（细胞粘附、活性药物负载等），拓展了其组织工程应用。 我司AlgMA产品通过严格的原料筛选及品质检测，具有稳定的理化性质，其在可见光照射下20秒内固化成胶，生物相容性良好，材料可扩展性强，能够提供多种黏弹特性以适应不同应用领域。AlgMA可用来搭配GelMA和HAMA水凝胶，更好的模拟皮肤、软骨等体内组织微环境，获得更优的细胞3D培养及生物墨水方案。 使用方法：?? 1. 甲基丙烯酸酯化海藻酸钠 (Methacrylated Alginate，ALMA) 是一种光敏生物材料；?? 2. ALMA 与蓝光或紫外光引发剂配合使用，可在蓝光或紫外光作用下交联固化； 3. ALMA 配制的浓度越高，固化后的硬度也越大；?? 4. ALMA 具有良好的生物相容性，可与细胞混合后进行生物3D打印。 每一批次的ALMA 均经 1H NMR，HPLC和细胞学检测，证实其化学结构，MA 化程度 20~30%，无细胞毒性；ALMA配制的水凝胶，加入蓝光引发剂LAP后，可在蓝光作用下迅速固化。 使用方法：? 1. 称取打印所需量的ALMA，丙酮除菌； 2. 在无菌条件下， 配制 2%-3%的ALMA 溶液，过夜溶解；? 3. 与细胞和蓝光引发剂 LAP 混合，置入蓝光生物3D打印机的墨盒； 4. 三维打印，蓝光固化。
Product Description： Methacrylylated sodium alginate (AlgMA) imparts light curing ability by introducing methacrylic groups on the molecular chain of sodium alginate. Compared with traditional divalent ion (calcium ion, etc.) cross-linking, the light-curing cross-linking method is more portable, and the internal uniformity of the gel is good. AlgMA-based material systems have been widely used in many biomedical research fields, including: tumor model construction, cell loading, wound dressings, controlled drug release, dental impressions, etc. In addition, both -OH and -COOH in the structural unit of sodium alginate can be used as chemically active sites, and more active groups can be introduced through chemical modification to give it new properties (cell adhesion, active drug loading, etc.) , Has expanded its application of tissue engineering. Our AlgMA products have passed strict raw material screening and quality testing, and have stable physical and chemical properties. They solidify into glue within 20 seconds under visible light irradiation. They have good biocompatibility, strong material scalability, and can provide a variety of viscoelastic properties. To adapt to different application areas. AlgMA can be used with GelMA and HAMA hydrogels to better simulate the microenvironment of skin, cartilage and other internal tissues, and obtain better cell 3D culture and bio-ink solutions. Instructions: 2. ALMA can be cured with a light initiator under blue or UV light;? 3. The stiffness of ALMA hydrogel is related to the concentration. The higher the concentration is,?the harder the stiffness is after curing; 4. ALMA has good biocompatibility, it can be mixed with cells for 3D bioprinting.? Quality Control:? Each batch of ALMA was tested by 1H NMR, HPLC and cytology to confirm its chemical?structure, degree of methacrylation 20~30%, and non-cytotoxity; when mixed with LAP, it can be?rapidly cured under the blue light? Recommended procedure:? 1. Weight ALMA for printing; sterilize it with acetone; 2. Dissolve ALMA in medium overnight to create the 2%-3% solution; 3. Mix the ALMA with LAP and cells, load it in the cartridge of the blue-light 3D bio-printer;? 4. Start 3D printing and blue-light solidification.? |
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化学和物理性质
| 敏感性 | 对光线敏感 |
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产品问答
产品问答
上海阿拉丁生化科技股份有限公司
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