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基本描述
| 别名 | 羟基积雪草甙 |
|---|---|
| 规格或纯度 | 98% |
| 英文名称 | Madecassoside |
| 应用 | 抑郁症、烧伤性瘢痕、抗癌、防治冠心病、心肌梗死、脑血栓，脑梗塞，增强记忆，皮肤增白。 |
| 运输条件 | 常规运输 |
| 产品介绍 |
抑郁症、烧伤性瘢痕、抗癌、防治冠心病、心肌梗死、脑血栓，脑梗塞，增强记忆，皮肤增白。 |
名称和标识符
| IUPAC Name | [(2S,3R,4S,5S,6R)-6-[[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl] (1S,2R,4aS,6aR,6aR,6bR,8R,8aR,9R,10R,11R,12aR,14bS)-8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate |
|---|---|
| INCHI | InChI=1S/C48H78O20/c1-19-10-11-48(13-12-46(6)22(28(48)20(19)2)8-9-27-44(4)14-24(52)39(61)45(5,18-50)38(44)23(51)15-47(27,46)7)43(62)68-42-35(59)32(56)30(54)26(66-42)17-63-40-36(60)33(57)37(25(16-49)65-40)67-41-34(58)31(55)29(53)21(3)64-41/h8,19-21,23-42,49-61H,9-18H2,1-7H3/t19-,20+,21+,23-,24-,25-,26-,27-,28+,29+,30-,31-,32+,33-,34-,35-,36-,37-,38-,39+,40-,41+,42+,44-,45+,46+,47-,48+/m1/s1 |
| InChi Key | BNMGUJRJUUDLHW-CIZDPPTDSA-N |
| Canonical SMILES | CC1CCC2(CCC3(C(=CCC4C3(CC(C5C4(CC(C(C5(C)CO)O)O)C)O)C)C2C1C)C)C(=O)OC6C(C(C(C(O6)COC7C(C(C(C(O7)CO)OC8C(C(C(C(O8)C)O)O)O)O)O)O)O)O |
| PubChem CID | 45356919 |
| 分子量 | 975.12 |
化学和物理性质
| 密度 | 1.4700 |
|---|
产品问答
产品问答
参考文献
| 1. Mu-Rong Liu,Ting Han,Yao Chen,Lu-Ping Qin,Han-Chen Zheng,Yao-Cheng Rui. (2004-11-13) [Effect of madecassoside on depression behavior of mice and activities of MAO in different brain regions of rats].. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 2 ((6)): (440-444). [PMID:15539023] |
| 2. Guangtao Jia,Xiuyang Lu. (2008-05-07) Enrichment and purification of madecassoside and asiaticoside from Centella asiatica extracts with macroporous resins.. Journal of chromatography. A, 1193 ((1-2)): (136-141). [PMID:18457845] |
| 3. Marek Haftek,Sophie Mac-Mary,Marie-Aude Le Bitoux,Pierre Creidi,Sophie Seité,André Rougier,Philippe Humbert. (2008-05-28) Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin.. Experimental dermatology, 17 ((11)): (946-952). [PMID:18503551] |
| 4. Mei Liu,Yue Dai,Xiujuan Yao,Ying Li,Yubin Luo,Yufeng Xia,Zhunan Gong. (2008-07-26) Anti-rheumatoid arthritic effect of madecassoside on type II collagen-induced arthritis in mice.. International immunopharmacology, 8 ((11)): (1561-1566). [PMID:18652917] |
| 5. Mingzhe Gao,Xiaoyan Yuan,Hongbin Xiao. (2008-08-30) [Preparation of asiaticoside and madecassoside from the extract of Centella asiatica (L.) Urb using preparative high performance liquid chromatography].. Se pu = Chinese journal of chromatography, 26 ((3)): (362-365). [PMID:18724677] |
| 6. Joana Gomes,Teresa Pereira,Catarina Vilarinho,Maria da Luz Duarte,Celeste Brito. (2010-02-09) Contact dermatitis due to Centella asiatica.. Contact dermatitis, 62 ((1)): (54-55). [PMID:20136880] |
| 7. T Winitthana,N Niwattisaiwong,C Patarapanich,M H Tantisira,S Lawanprasert. (2011-02-26) In vitro inhibitory effects of asiaticoside and madecassoside on human cytochrome P450.. Toxicology in vitro : an international journal published in association with BIBRA, 25 ((4)): (890-896). [PMID:21349323] |
| 8. Difei Bian,Mei Liu,Ying Li,Yufeng Xia,Zhunan Gong,Yue Dai. (2012-07-26) Madecassoside, a triterpenoid saponin isolated from Centella asiatica herbs, protects endothelial cells against oxidative stress.. Journal of biochemical and molecular toxicology, 26 ((10)): (399-406). [PMID:22829481] |
| 9. P Puttarak,P Panichayupakaranant. (2012-09-13) Factors affecting the content of pentacyclic triterpenes in Centella asiatica raw materials.. Pharmaceutical biology, 50 ((12)): (1508-1512). [PMID:22966846] |
| 10. Xueqing Shen,Miaomiao Guo,Haiyuan Yu,Dan Liu,Zhi Lu,Yanhua Lu. (2018-11-20) Propionibacterium acnes related anti-inflammation and skin hydration activities of madecassoside, a pentacyclic triterpene saponin from Centella asiatica.. Bioscience, biotechnology, and biochemistry, 83 ((3)): (561-568). [PMID:30452312] |
| 11. Komal Rani,Mitali Tyagi,Mohit Mazumder,Akanksha Singh,Annaian Shanmugam,Krishna Dalal,Manoj Pillai,Gourinath Samudrala,Saroj Kumar,Alagiri Srinivasan. (2020-03-15) Accelerated identification of serine racemase inhibitor from Centella asiatica.. Scientific reports, 10 ((1)): (4640-4640). [PMID:32170206] |
| 12. F Bonté,M Dumas,C Chaudagne,A Meybeck. (1995-01-01) [Comparative activity of asiaticoside and madecassoside on type I and III collagen synthesis by cultured human fibroblasts].. Annales pharmaceutiques francaises, 53 ((1)): (38-42). [PMID:7741425] |
| 13. J H Sampson,A Raman,G Karlsen,H Navsaria,I M Leigh. (2001-06-22) In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 8 ((3)): (230-235). [PMID:11417919] |
| 14. Mercè Bonfill,Susana Mangas,Rosa M Cusidó,Lidia Osuna,M Teresa Pi?ol,Javier Palazón. (2005-10-06) Identification of triterpenoid compounds of Centella asiatica by thin-layer chromatography and mass spectrometry.. Biomedical chromatography : BMC, 20 ((2)): (151-153). [PMID:16206136] |
| 15. Feng-Lun Zhang,Ying-Jie Wei,Jia Zhu,Zhu-Nan Gong. (2007-08-19) Simultaneous quantitation of three major triterpenoid glycosides in Centella asiatica extracts by high performance liquid chromatography with evaporative light scattering detection.. Biomedical chromatography : BMC, 22 ((2)): (119-124). [PMID:17703474] |
| 16. Gui-Gui Li,Guang-Xing Bian,Jian-Ping Ren,Li-Qing Wen,Min Zhang,Qiu-Jun Lü. (2007-08-21) [Protective effect of madecassoside against reperfusion injury after regional ischemia in rabbit heart in vivo].. Yao xue xue bao = Acta pharmaceutica Sinica, 42 ((5)): (475-480). [PMID:17703767] |
| 17. Guang-Xing Bian,Gui-Gui Li,Yun Yang,Rui-Ting Liu,Jian-Ping Ren,Li-Qing Wen,Shao-Ming Guo,Qiu-Jun Lu. (2008-03-04) Madecassoside reduces ischemia-reperfusion injury on regional ischemia induced heart infarction in rat.. Biological & pharmaceutical bulletin, 31 ((3)): (458-463). [PMID:18310910] |
| 18. Mei Liu,Yue Dai,Ying Li,Yubin Luo,Fang Huang,Zhunan Gong,Qingyu Meng. (2008-05-20) Madecassoside isolated from Centella asiatica herbs facilitates burn wound healing in mice.. Planta medica, 74 ((8)): (809-815). [PMID:18484522] |
| 19. Ok Tae Kim,Sun Hee Kim,Kiyoshi Ohyama,Toshiya Muranaka,Yong Eui Choi,Hyeon Yong Lee,Min Young Kim,Baik Hwang. (2010-03-03) Upregulation of phytosterol and triterpene biosynthesis in Centella asiatica hairy roots overexpressed ginseng farnesyl diphosphate synthase.. Plant cell reports, 29 ((4)): (403-411). [PMID:20195611] |
| 20. Wen-Jing Han,Yu-Feng Xia,Yue Dai. (2011-03-18) Development and validation of high-performance liquid chromatography/electrospray ionization mass spectrometry for assay of madecassoside in rat plasma and its application to pharmacokinetic study.. Biomedical chromatography : BMC, 26 ((1)): (26-32). [PMID:21413047] |
| 21. Jie Song,Huan Xu,Qian Lu,Zhao Xu,Difei Bian,Yufeng Xia,Zhifeng Wei,Zhunan Gong,Yue Dai. (2012-03-01) Madecassoside suppresses migration of fibroblasts from keloids: involvement of p38 kinase and PI3K signaling pathways.. Burns : journal of the International Society for Burn Injuries, 38 ((5)): (677-684). [PMID:22360962] |
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