| 规格或纯度 | 10mM in DMSO |
|---|---|
| 英文名称 | (±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid |
| 别名 | 水溶性维生素E |
| 英文别名 | trolox|53188-07-1|6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid|TROLOX C|6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid|3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid|56305-04-5|2H-1-Benzopyran-2-carboxylic a |
| 生化机理 | 抗氧化剂维生素E衍生物。表现出脂质过氧化，DPPH°清除和HO°清除活性。经常用作抗氧化剂标准。具有细胞渗透性和水溶性。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Trolox is an antioxidant derived from water-soluble vitamin E, with oxygen quenching activity. The activity of Trolox ranges between ferulic acid and p-coumaric acid. Studies show that lipid peroxidation, cytotoxicity, and apoptosis induced by cytochrome P450 2E1 in Hep G2 cells is blocked in the presence of Trolox. It has been observed that Trolox can quench free radicals and inhibit methylmercury (MeHg)-induced reactive oxygen species (ROS) generation in C6 glial cells. In addition, Trolox has demonstrated the ability to reduce cytotoxicity of Microcystis aeruginosa and microcystin-LR in Artemia franciscana nauplii. (±)-6-羟基-2,5,7,8-四甲基色满-2-羧酸（Trolox）展现出了自由基清除和抗氧化活性 Trolox is an antioxidant derived from water-soluble vitamin E, with oxygen quenching activity. The activity of Trolox ranges between ferulic acid and p-coumaric acid. Studies show that lipid peroxidation, cytotoxicity, and apoptosis induced by cytochrome P450 2E1 in Hep G2 cells is blocked in the presence of Trolox. It has been observed that Trolox can quench free radicals and inhibit methylmercury (MeHg)-induced reactive oxygen species (ROS) generation in C6 glial cells. In addition, Trolox has demonstrated the ability to reduce cytotoxicity of Microcystis aeruginosa and microcystin-LR in Artemia franciscana nauplii. (±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (Trolox) exhibits radical scavenging and antioxidant activities |
| IUPAC Name | 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromene-2-carboxylic acid |
|---|---|
| INCHI | InChI=1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17) |
| InChi Key | GLEVLJDDWXEYCO-UHFFFAOYSA-N |
| Canonical SMILES | CC1=C(C2=C(CCC(O2)(C)C(=O)O)C(=C1O)C)C |
| WGK Germany | 2 |
| RTECS | DJ2273000 |
| PubChem CID | 40634 |
| 分子量 | 250.29 |
| Beilstein号 | 1384050 |
| Reaxy-Rn | 5052542 |
| 熔点 | 187-189 °C |
|---|
| 象形图 |
Harmful |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation |
| 预防措施声明 | P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319 |
| WGK Germany | 2 |
| RTECS | DJ2273000 |
| Reaxy-Rn | 5052542 |
| 个人防护装备 | dust mask type N95 (US)， Eyeshields， Gloves |
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