Cas(6066-82-6), N-羟基琥珀酰亚胺-阿拉丁试剂, N-羟基丁二酰亚胺;NHS,N-Hydroxysuccinimide,

货号 (SKU)	包装规格	是否现货
H109330-5g	5g	现货
H109330-25g	25g	现货
H109330-100g	100g	现货
H109330-500g	500g	现货
H109330-1kg	1kg	现货
H109330-2.5kg	2.5kg	现货
H109330-12×500g	12×500g	现货

基本描述

规格或纯度	98%
英文名称	N-Hydroxysuccinimide
别名	N-羟基丁二酰亚胺;NHS;1-羟基-2,5-吡咯烷二酮
英文别名	N-Hydroxysuccinimide\|6066-82-6\|1-hydroxypyrrolidine-2,5-dione\|HOSu\|1-Hydroxysuccinimide\|Hydroxysuccinimide\|1-Hydroxy-2,5-pyrrolidinedione\|2,5-Pyrrolidinedione, 1-hydroxy-\|Succinimide, N-hydroxy-\|N-hydroxy succinimide\|N-hydroxysuccinimide (HOSu)\|MFCD000055
生化机理	胺反应性化合物。用于修饰，标记和交联胺基。用于蛋白质-蛋白质相互作用，N-末端残基鉴定以及磷酸化或O-糖基化残基位置的工具。
储存温度	2-8°C储存,充氩
运输条件	冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	N-Hydroxysuccinimide, commonly known as NHS, is a hydroxylated succinimide that is widely used in the activation of carboxylic acids to NHS-esters to promote coupling with nucleophiles. This approach is most commonly employed in activating the free acid forms of fluorophores for promoting conjμgation of these fluorophores to amine residues of proteins. Use of NHS ester activation has also been described in the synthesis of N-acyl amino acids.Useful in the carbodiimide method for improved amidations and peptide couplings. N-羟基琥珀酰亚胺可以在存在二环己基碳二亚胺的条件下在羧酸中通过脱水反应合成N-羟基琥珀酰亚胺酯。 N-羟基琥珀酰亚胺已用于中间介质的合成如： · N-丁二酰亚胺3-(二-三-丁基氟硅烷）苯甲酸 · 4-[2,2-双[(对-甲苯磺酰)-甲基]乙酰]苯甲酸-NHS酯 · N-丁二酰亚胺3-碘苯甲酸它还用于微流体整合的表面等离子体共振（SPR）平台的微通道的表面修饰的实验方法中，用于对细菌病原体进行检测和定量。碳二亚胺方法中使用的添加剂用于改良的酰胺化[1]及肽偶联。 N-Hydroxysuccinimide, commonly known as NHS, is a hydroxylated succinimide that is widely used in the activation of carboxylic acids to NHS-esters to promote coupling with nucleophiles. This approach is most commonly employed in activating the free acid forms of fluorophores for promoting conjugation of these fluorophores to amine residues of proteins. Use of NHS ester activation has also been described in the synthesis of N-acyl amino acids. Useful in the carbodiimide method for improved amidations and peptide couplings.

名称和标识符

EC号	228-001-3
IUPAC Name	1-hydroxypyrrolidine-2,5-dione
INCHI	InChI=1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2
InChi Key	NQTADLQHYWFPDB-UHFFFAOYSA-N
Canonical SMILES	C1CC(=O)N(C1=O)O
WGK Germany	3
PubChem CID	80170
分子量	115.09
Beilstein号	113913
Reaxy-Rn	113913

化学和物理性质

溶解性	Soluble in water, dimethyl formamide, alcohols and ethyl acetate. Insoluble in cold ether.
密度	1.649
敏感性	对热、湿度敏感
熔点	95-98°C

安全和危险性（GHS）

象形图	Harmful
信号词	Warning
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319
WGK Germany	3
Reaxy-Rn	113913
个人防护装备	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

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