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研究领域
干细胞
信号通路
转化生长因子β
Go 6983, 广谱PKC抑制剂

Go 6983, 广谱PKC抑制剂

高效，快速作用的广谱PKC抑制剂

规格或纯度: ≥96%

CAS编号: 133053-19-7
分子式: C₂₆H₂₆N₄O₃
分子量: 442.51
PubChem编号: 3499

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货号 (SKU)	包装规格	是否现货	价格	数量
G129385-1mg	1mg	现货
G129385-5mg	5mg	期货
G129385-10mg	10mg	现货
G129385-25mg	25mg	期货
G129385-100mg	100mg	期货

查看相关系列

protein kinase C alpha Inhibitor protein kinase C beta Inhibitor protein kinase C delta Inhibitor protein kinase C gamma Inhibitor protein kinase C zeta Inhibitor

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基本描述

规格或纯度	≥96%
英文名称	Go 6983
别名	3-[1- [3-(二甲氨基)丙基]-5-甲氧基-1H-吲哚-3-基] -4-(1H-吲哚-3-基)-1H-吡咯-2,5-二酮
英文别名	go 6983\|133053-19-7\|Go6983\|Goe 6983\|3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione\|Go-6983\|3-(1-(3-(dimethylamino)propyl)-5-methoxy-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione\|Go-6893\|G? 6983\|3-[1-
生化机理	蛋白激酶C（PKC）抑制剂选择性抑制几种 PKC 同工酶（PKCα和PKCβ的IC50=7nM；PKCγ 为6 nM；PKCδ 为10 nM；PKCζ 为60nM），但不抑制PKCμ（IC50=20 mM）。
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有关更多信息，请参考SDS。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	GO6983 has been used as a protein kinase C (PKC) inhibitor to study its effects on the nuclear import. It has also been used as a supplement in Fc medium to culture mouse embryonic stem (mES) cells on mitomycin C treated mouse embryonic fibroblasts (MEFs).? GO6983 has been used as a protein kinase C (PKC) inhibitor to study its effects on the nuclear import. It has also been used as a supplement in Fc medium to culture mouse embryonic stem (mES) cells on mitomycin C treated mouse embryonic fibroblasts (MEFs).?

名称和标识符

IUPAC Name	3-[1-[3-(dimethylamino)propyl]-5-methoxyindol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
INCHI	InChI=1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
InChi Key	LLJJDLHGZUOMQP-UHFFFAOYSA-N
Canonical SMILES	CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
WGK Germany	3
PubChem CID	3499
分子量	442.51

数据库链接

CAS Registry No.	133053-19-7
PubChem CID	3499
ChEMBL Ligand	CHEMBL261491

化学和物理性质

溶解性	DMSO: 10 mg/mL, clear

安全和危险性（GHS）

象形图	Harmful
信号词	Warning
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319
WGK Germany	3
个人防护装备	dust mask type N95 (US)， Eyeshields， Gloves

关联配体

Ligand ID	5192
名称	Gö 6983
别名	Go 6983
类别	Synthetic organic
学名	3-{1-[3-(dimethylamino)propyl]-5-methoxy-1H-indol-3-yl}-4-(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
生物活性评价	We have mapped the data from to the human PKC isoforms, but the species of the recombinant kinases used is unclear in the article.
评价	Gö6983 is a pan-PKC inhibitor .

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参考文献

1. Gschwendt M, Dieterich S, Rennecke J, Kittstein W, Mueller HJ, Johannes FJ. (1996) Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes.. FEBS Lett, 392 (2): (77-80). [PMID:8772178]
2. Kataura T et al.. (2020) A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.. Autophagy, (): (1-17). [PMID:32762399]
3. K?nig B et al.. (2019) A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength.. Elife, 8 (): (). [PMID:31210638]
4. Toufaily C et al.. (2021) Addition of a carboxy-terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice.. Elife, 10 (): (). [PMID:34939930]
5. D'Souza RS et al.. (2020) Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex.. Elife, 9 (): (). [PMID:32234213]
6. De Virgiliis F et al.. (2020) Enriched conditioning expands the regenerative ability of sensory neurons after spinal cord injury via neuronal intrinsic redox signaling.. Nat Commun, 11 (): (6425). [PMID:33349630]
7. Barakat TS et al.. (2018) Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells.. Cell Stem Cell, 23 (2): (276-288.e8). [PMID:30033119]
8. Lv G et al.. (2020) Inhibition of carrageenan-induced dental inflammatory responses owing to decreased TRPV1 activity by Dexmedetomidine.. J Inflamm (Lond), 17 (): (18). [PMID:32377171]
9. Nguyen GT et al.. (2020) SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst.. Elife, 9 (): (). [PMID:32352382]

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