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基本描述
| 规格或纯度 | 10mM in DMSO |
|---|---|
| 英文名称 | Favipiravir (T-705) |
| 英文别名 | 6-fluoro-3-hydroxypyrazine-2-carboxamide |
| 生化机理 | Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections. |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Information Favipiravir (T-705) is a potent and selectiveRNA-dependent RNA polymeraseinhibitor, used to treat influenza virus infections. Favipiravir shows anti-influenza virus activities with IC50 ranged from 0.013 to 0.48 μg/ml for the influenza A viruses, from 0.039 to 0.089 μg/ml for the influenza B viruses, and from 0.030 to 0.057 μg/ml for the influenza C viruses. In mammalian cell lines (MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells), Favipiravir shows no cytotoxicity at concentrations up to 1,000 μg/ml. In MDCK cells inoculated with seasonal influenza A (H1N1) viruses, Favipiravir induces lethal mutagenesis. In?vivo In influenza virus-infected mice, Favipiravir (200 mg/kg/day, p.o.) protects the mice from death from influenza virus infection. In mice experimentally infected with Ebola virus, Favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6days after initiation of treatment, respectively. cell?lines： Concentrations：1000 μg/mL Incubation?Time：3 days Powder?Purity:≥99% |
名称和标识符
| Canonical SMILES | NC(=O)C1=NC(=CN=C1O)F |
|---|---|
| 分子式 |
C5H4FN3O2 |
| 分子量 | 157.1 |
化学和物理性质
| 溶解性 | Solubility (25°C) In vitro ? ? ? |
|---|
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产品问答
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