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呋咯地辛

规格或纯度: 97%

CAS编号: 209799-67-7
分子式: C₁₁H₁₄N₄O₄
分子量: 266.2533
PubChem编号: 135409409

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库存信息

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货号 (SKU)	包装规格	是否现货	价格	数量
F175696-100mg	100mg	期货

查看相关系列

Plasmodium falciparum purine nucleoside phosphorylase Plasmodium falciparum purine nucleoside phosphorylase Inhibitor purine nucleoside phosphorylase Inhibitor

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基本描述

规格或纯度	97%
英文名称	Forodesine
储存温度	室温
运输条件	常规运输

名称和标识符

IUPAC Name	7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
INCHI	InChI=1S/C11H14N4O4/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19)/t5-,7+,9-,10+/m1/s1
InChi Key	IWKXDMQDITUYRK-KUBHLMPHSA-N
Canonical SMILES	C1=C(C2=C(N1)C(=O)NC=N2)C3C(C(C(N3)CO)O)O
分子式	C₁₁H₁₄N₄O₄
PubChem CID	135409409
分子量	266.2533

数据库链接

PubChem CID	135409409
ChEBI	CHEBI:43362
ChEMBL Ligand	CHEMBL218291
CAS Registry No.	209799-67-7
Wikipedia	Forodesine
RCSB PDB Ligand	IMH
DrugCentral Ligand	5229

靶标

Target ID

2841

名称

purine nucleoside phosphorylase

缩写名

PNP

家族

Nucleoside synthesis and metabolism

别名

VIP₂

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	2	289	14q11.2	PNP	purine nucleoside phosphorylase
Mouse	2	289	14 26.31 cM	Pnp	purine-nucleoside phosphorylase
Rat	2	289	15p14	Pnp	purine nucleoside phosphorylase

RefSeq Protein

NP_000261 (Hs) , NP_001099501 (Rn)

Protein GI

157168362 (Hs) , 7305395 (Mm) , 157822819 (Rn)

RefSeq Nucleotide

NM_000270 (Hs) , NP_038660 (Mm) , NM_013632 (Mm) , NM_001106031 (Rn)

UniProtKB

P00491 (Hs) , P23492 (Mm) , P85973 (Rn)

OMIM

164050 (Hs)

Entrez Gene

4860 (Hs) , 18950 (Mm) , 290029 (Rn)

Ensembl Gene

ENSG00000198805 (Hs) , ENSRNOG00000009982 (Rn) , ENSMUSG00000115338 (Mm)

DrugBank Target

P00491 (Hs)

Immunopaedia Search

purine nucleoside phosphorylase (N/A)

ChEMBL Target

CHEMBL2395 (Rn) , CHEMBL4338 (Hs) , CHEMBL2215 (Mm)

Target ID

3077

名称

Plasmodium falciparum purine nucleoside phosphorylase

缩写名

PfPNP

家族

Nucleoside synthesis and metabolism (Plasmodium spp.)

别名

Kir4.1

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Plasmodium falciparum 3D7	2	245	18p11	PNP	purine nucleoside phosphorylase

UniProtKB

Q8I3X4 (Pf3D7)

PlasmoDB

PF3D7_0513300 (Pf3D7)

ChEMBL Target

CHEMBL4523389 (Pf3D7)

关联配体

Ligand ID	8272
名称	forodesine
别名	BCX-1777
类别	Synthetic organic
学名	7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydropyrrolo[2,3-e]pyrimidin-4-one
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Forodesine is a picomolar inhibitor of purine nucleoside phosphorylase (PNP) . The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
配体家族	Antimalarial ligands

参考文献

1. Kicska GA, Long L, H?rig H, Fairchild C, Tyler PC, Furneaux RH, Schramm VL, Kaufman HL. (2001) Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes.. Proc Natl Acad Sci USA, 98 (8): (4593-8). [PMID:11287638]
2. Kicska GA, Tyler PC, Evans GB, Furneaux RH, Schramm VL, Kim K. (2002) Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase.. J Biol Chem, 277 (5): (3226-31). [PMID:11706018]
3. Kicska GA, Tyler PC, Evans GB, Furneaux RH, Kim K, Schramm VL. (2002) Transition state analogue inhibitors of purine nucleoside phosphorylase from Plasmodium falciparum.. J Biol Chem, 277 (5): (3219-25). [PMID:11707439]
4. Miles RW, Tyler PC, Furneaux RH, Bagdassarian CK, Schramm VL. (1998) One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase.. Biochemistry, 37 (24): (8615-21). [PMID:9628722]