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盐酸法舒地尔

环状核苷酸依赖性和Rho激酶抑制剂

规格或纯度: 98%

CAS编号: 105628-07-7
分子式: C₁₄H₁₇N₃O₂S·HCl
分子量: 327.83
MDL号: MFCD00943198
PubChem编号: 163751

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货号 (SKU)	包装规格	是否现货	价格	数量
F122336-100mg	100mg	现货
F122336-250mg	250mg	现货
F122336-500mg	500mg	现货
F122336-1g	1g	现货
F122336-5g	5g	现货
F122336-25g	25g	现货

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六元杂环化合物吡啶类

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基本描述

规格或纯度	98%
英文名称	Fasudil Hydrochloride
别名	盐酸法舒地尔\|5-(1-高哌嗪)磺酰基异喹啉盐酸盐\|(5-异喹啉磺酰基)高哌嗪盐酸盐
英文别名	Fasudil hydrochloride\|105628-07-7\|Fasudil HCl\|Eril\|Fasudil (HA-1077) HCl\|5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride\|Fasudil (Hydrochloride)\|AT-877\|Fasudil Monohydrochloride\|ha-1077\|SQ04N8S7BR\|Fasudil, Monohydrochloride Salt\|DTXSID1045615\|MF
生化机理	环状核苷酸依赖性蛋白激酶抑制剂和Rho相关激酶抑制剂（IC50 =10.7μM）。在体内抑制MMP-2表达并诱导胶质母细胞瘤细胞凋亡。Ca2 +拮抗剂和血管扩张剂。还抑制血管平滑肌细胞的增殖。
应用	A selective ROCK inhibitor
储存温度	避光,-20°C储存
运输条件	超低温冰袋运输
产品介绍	Fasudil, Monohydrochloride Salt is a cell-permeable, selective ROCK inhibitor which induces neuroprotection in vitro. Studies sμggest that when acting as a ROCK inhibitor, Fasudil reduces neutrophil transendothelial migration by diminishing cytoskeletal rearrangement of endothelial cells. In addition, Fasudil significantly protects against MeHg-induced axonal degeneration and apoptotic cell death in cultured cortical neurons. Alternate studies show that Fasudil plays an important role in osteoblastic differentiation of stromal cells via increasing the mRNA expression of collagen-I, osteocalcin, and bone morphogenetic protein-2 (BMP-2). Furthermore, noggin, a BMP-2 antagonist can reverse the effects of Fasudil induced mRNA expression of collagen-I and osteocalcin. Upon inhibition of Rho-kinase, Fasudil significantly stimulates FGF-2-induced accumulation of vascular endothelial growth factor (VEGF). Fasudil, Monohydrochloride Salt is an inhibitor of cGKI, MSK1, PKA, PRK2, Rock-2, AMPK, CaMKII, Polycystin-1 and Rsk-1.A selective ROCK inhibitor Fasudil, Monohydrochloride Salt is a cell-permeable, selective ROCK inhibitor which induces neuroprotection in vitro. Studies suggest that when acting as a ROCK inhibitor, Fasudil reduces neutrophil transendothelial migration by diminishing cytoskeletal rearrangement of endothelial cells. In addition, Fasudil significantly protects against MeHg-induced axonal degeneration and apoptotic cell death in cultured cortical neurons. Alternate studies show that Fasudil plays an important role in osteoblastic differentiation of stromal cells via increasing the mRNA expression of collagen-I, osteocalcin, and bone morphogenetic protein-2 (BMP-2). Furthermore, noggin, a BMP-2 antagonist can reverse the effects of Fasudil induced mRNA expression of collagen-I and osteocalcin. Upon inhibition of Rho-kinase, Fasudil significantly stimulates FGF-2-induced accumulation of vascular endothelial growth factor (VEGF). Fasudil, Monohydrochloride Salt is an inhibitor of cGKI, MSK1, PKA, PRK2, Rock-2, AMPK, CaMKII, Polycystin-1 and Rsk-1. A selective ROCK inhibitor

名称和标识符

IUPAC Name	5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;hydrochloride
INCHI	InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H
InChi Key	LFVPBERIVUNMGV-UHFFFAOYSA-N
Canonical SMILES	C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl
WGK Germany	1
RTECS	HM4033500
PubChem CID	163751
分子量	327.83
Reaxy-Rn	5466340

化学和物理性质

溶解性	溶于water, 最高浓度 (mg/mL): 32.78, 最高浓度(mM): 100；溶于DMSO, 最高浓度 (mg/mL): 24.59, 最高浓度(mM): 75
敏感性	对光线敏感
折光率	1.62
沸点	506.2° C
熔点	222 °C

安全和危险性（GHS）

象形图	Harmful
信号词	Warning
危险声明	H302: Harmful if swallowed
预防措施声明	P501,P264,P270,P330,P301+P317
WGK Germany	1
RTECS	HM4033500
Reaxy-Rn	5466340
Merck Index	3942

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