| 规格或纯度 | 0.5M in THF |
|---|---|
| 英文名称 | (1,3-Dioxolan-2-ylmethyl)magnesium bromide solution |
| 英文别名 | 2-[(Bromomagnesio)methyl]-1,3-dioxolane；Bromo(1,3-dioxolan-2-ylmethyl)magnesium |
| 储存温度 | 充氩 |
| 运输条件 | 常规运输 |
| 产品介绍 |
应用 （1,3-二氧戊环-2-基甲基）溴化镁是一种格氏试剂，可用于制备：3-[11C]-丙醛，一种用于合成放射标记化合物[11C]SN-38的关键中间体，其中SN-38代表7-乙基-10-羟基喜树碱。通过与D-甘油醛反应制备1-[(S)-2,2-二甲基-(1,3)-二氧戊环-4-基]-4-(1,3-二氧戊环2-基)-2-醇，其可进一步被用于合成不饱和核苷。一种双环羧酸盐中间体，可用于spirovibsanin A的全合成。 Description (1,3-Dioxolan-2-ylmethyl)magnesium bromide is a Grignard reagent that can be used to prepare:3-[11C]-Propionaldehyde, a key intermediate for the synthesis of radiolabeled compound [11C]SN-38, wherein SN-38 is 7-ethyl-10-hydroxy camptothecin.1-[(S)-2,2-Dimethyl-(1,3)-dioxolan-4-yl]-4-(1,3-dioxolan2-yl)-2-ol by reacting with D-glyceraldehyde, which is further used to synthesize unsaturated nucleosides.A bicyclo carboxylate intermediate, which is employed in the total synthesis of spirovibsanin A. |
| IUPAC Name | magnesium;2-methanidyl-1,3-dioxolane;bromide |
|---|---|
| INCHI | InChI=1S/C4H7O2.BrH.Mg/c1-4-5-2-3-6-4;;/h4H,1-3H2;1H;/q-1;;+2/p-1 |
| InChi Key | IERSPCAGKAOLSQ-UHFFFAOYSA-M |
| Canonical SMILES | [CH2-]C1OCCO1.[Mg+2].[Br-] |
| WGK Germany | 3 |
| PubChem CID | 4247254 |
| 分子量 | 191.31 |
| 密度 | 0.938g/mL at 25°C |
|---|---|
| 敏感性 | 对空气敏感 |
| 闪点(℉) | 1.4 °F |
| 闪点(℃) | -17 °C |
| 沸点 | 65-67 °C |
| 象形图 |
Corrosive |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H335: May cause respiratory irritation H351: Suspected of causing cancer H314: Causes severe skin burns and eye damage H302: Harmful if swallowed H225: Highly Flammable liquid and vapor |
| 预防措施声明 | P280,P321,P405,P501,P264,P260,P301+P330+P331,P304+P340,P363,P305+P354+P338,P302+P361+P354,P316 |
| WGK Germany | 3 |
| 个人防护装备 | Faceshields， full-face respirator (US)， Gloves， Goggles， multi-purpose combination respirator cartridge (US)， type ABEK (EN14387) respirator filter |
| RIDADR | UN29248(3)/PGII |
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