91高清自产国产拍,无码免费A级毛片大全,日本 欧美 国产中文字幕,99re热视频这里只有精品视频首页

首页   400-620-6333
提交您使用阿拉丁产品的研究文章，就得100元奖励！立即访问我们的提交页面.
语言
Chinese
切换导航
我的购物车
搜索
搜索444
高级搜索
菜单
账号
设置
语言
Chinese

2,4＇-二溴苯乙酮

规格或纯度: 98%
有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
D113568-5g 5g 现货 Stock Image
D113568-25g 25g 现货 Stock Image
D113568-100g 100g 期货 Stock Image
D113568-500g 500g 现货 Stock Image
大包装询价 添加到收藏夹 比较
查看相关系列
羰基化合物 衍生化试剂 酮
main product photo

基本描述

规格或纯度 98%
英文名称 2,4'-Dibromoacetophenone
别名 4-溴苯甲酰甲基溴；4′-溴苯甲酰甲基溴
英文别名 2-Bromo-1-(4-bromophenyl)ethanone;4'-Bromophenacyl bromide ;alpha,4'-Dibromoacetophenone
应用 A cell-permeable, and non-ATP competitive inhibitor of GSK-3β
储存温度 2-8°C储存,避光
运输条件 冰袋运输
产品介绍

GSK-3β Inhibitor VII is a phenyl α-bromomethyl ketone compound which acts as a cell-permeable, and non-ATP competitive inhibitor of glycogen synthase kinases (GSK-3&beta); (IC = 0.5 μM). This compound acts as an alkylating agent that is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 μM. Research has shown that glycogen synthase kinases have major roles in Wnt and Hedgehog signaling pathways and regulate the cell-division cycle, stem-cell renewal and differentiation, apoptosis, circadian rhythm, transcription and insulin action. This pertinent biological activity makes GSK inhibitors very useful research molecules.A cell-permeable, and non-ATP competitive inhibitor of GSK-3β


应用：

在 SnCl2 或 SmI3 存在的情况下与醛发生缩合反应以生成 α,β-不饱和酮。还用于羧酸的酯化反应。


GSK-3β Inhibitor VII is a phenyl α-bromomethyl ketone compound which acts as a cell-permeable, and non-ATP competitive inhibitor of glycogen synthase kinases (GSK-3&beta); (IC = 0.5 μM). This compound acts as an alkylating agent that is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 μM. Research has shown that glycogen synthase kinases have major roles in Wnt and Hedgehog signaling pathways and regulate the cell-division cycle, stem-cell renewal and differentiation, apoptosis, circadian rhythm, transcription and insulin action. This pertinent biological activity makes GSK inhibitors very useful research molecules.
A cell-permeable, and non-ATP competitive inhibitor of GSK-3β


Application：

Undergoes condensation reactions with aldehydes in the presence of SnCl2 or SmI3 to afford α,β-unsaturated ketones. Also useful in the esterification of carboxylic acids.

名称和标识符

EC号 202-783-6
IUPAC Name 2-bromo-1-(4-bromophenyl)ethanone
INCHI InChI=1S/C8H6Br2O/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2
InChi Key FKJSFKCZZIXQIP-UHFFFAOYSA-N
Canonical SMILES C1=CC(=CC=C1C(=O)CBr)Br
分子式

C8H6Br2O
UN Number 3261
PubChem CID 7454
Packing Group II
Beilstein号 607604
分子量 277.94

化学和物理性质

溶解性 Soluble in DMSO (5 mg/ml), methanol (20 mg/ml), toluene, and ethanol. Insoluble in water.
密度 1.848
敏感性 对热和光敏感
熔点 108-110°C

安全信息

一般危化品 一般危化品
象形图
ghs05

Corrosive
信号词 Danger
危险声明 H314: Causes severe skin burns and eye damage
H303: May be harmful if swallowed
预防措施声明 P280,P321,P405,P501,P264,P260,P301+P330+P331,P304+P340,P363,P305+P354+P338,P302+P361+P354,P316
WGK Germany 2
RTECS AM6950000
Reaxy-Rn 607604
Merck Index 1427

参考文献

1. P S F Barbosa,A M C Martins,A Havt,Daniela O Toyama,J S A M Evangelista,D P P Ferreira,P P Joazeiro,Luis O S Beriam,Marcos H Toyama,M C Fonteles,H S A Monteiro.  (2005-08-24)  Renal and antibacterial effects induced by myotoxin I and II isolated from Bothrops jararacussu venom..  Toxicon : official journal of the International Society on Toxinology,  46  ((4)):  (376-386).  [PMID:16115661]
2. Christopher L Sprague,Adnan A Elfarra.  (2005-09-01)  Protection of rats against 3-butene-1,2-diol-induced hepatotoxicity and hypoglycemia by N-acetyl-l-cysteine..  Toxicology and applied pharmacology,  207  ((3)):  (266-274).  [PMID:16129119]
3. Sanjaya Kuruppu,Shane Reeve,Yajnavalka Banerjee,R Manjunatha Kini,A Ian Smith,Wayne C Hodgson.  (2005-09-02)  Isolation and pharmacological characterization of cannitoxin, a presynaptic neurotoxin from the venom of the Papuan Taipan (Oxyuranus scutellatus canni)..  The Journal of pharmacology and experimental therapeutics,  315  ((3)):  (1196-1202).  [PMID:16135698]
4. Youngjin Park,A R Nor Aliza,David Stanley.  (2005-10-20)  A secretory PLA2 associated with tobacco hornworm hemocyte membrane preparations acts in cellular immune reactions..  Archives of insect biochemistry and physiology,  60  ((3)):  (105-115).  [PMID:16235259]
5. Angelo J Magro,Agnes A S Takeda,Andreimar M Soares,Marcos R M Fontes.  (2005-11-23)  Structure of BthA-I complexed with p-bromophenacyl bromide: possible correlations with lack of pharmacological activity..  Acta crystallographica. Section D, Biological crystallography,  61  ((Pt 12)):  (1670-1677).  [PMID:16301802]
6. Taomin Huang,Zhong He,Bei Yang,Luping Shao,Xiaowei Zheng,Gengli Duan.  (2006-01-18)  Simultaneous determination of captopril and hydrochlorothiazide in human plasma by reverse-phase HPLC from linear gradient elution..  Journal of pharmaceutical and biomedical analysis,  41  ((2)):  (644-648).  [PMID:16413728]
7. D P Marchi-Salvador,C A H Fernandes,S F Amui,A M Soares,M R M Fontes.  (2006-06-07)  Crystallization and preliminary X-ray diffraction analysis of a myotoxic Lys49-PLA2 from Bothrops jararacussu venom complexed with p-bromophenacyl bromide..  Acta crystallographica. Section F, Structural biology and crystallization communications,  62  ((Pt 6)):  (600-603).  [PMID:16754993]
8. Lei Wang,Wolfgang Armbruster,Dieter Jendrossek.  (2007-04-03)  Production of medium-chain-length hydroxyalkanoic acids from Pseudomonas putida in pH stat..  Applied microbiology and biotechnology,  75  ((5)):  (1047-1053).  [PMID:17401563]
9. Johanna Mansfeld,Renate Ulbrich-Hofmann.  (2007-08-19)  Secretory phospholipase A2-alpha from Arabidopsis thaliana: functional parameters and substrate preference..  Chemistry and physics of lipids,  150  ((2)):  (156-166).  [PMID:17692835]
10. Xiao-Wang Qu,Wen-Pei Liu,Zheng-Yu Qi,Zhao-Jun Duan,Li-Shu Zheng,Zi-Zhou Kuang,Wan-Ju Zhang,Yun-De Hou.  (2007-11-06)  Phospholipase A2-like activity of human bocavirus VP1 unique region..  Biochemical and biophysical research communications,  365  ((1)):  (158-163).  [PMID:17981142]
11. Heiki Vija,Mari Samel,Ene Siigur,Anu Aasp?llu,Katrin Trummal,Külli T?nism?gi,Juhan Subbi,Jüri Siigur.  (2009-05-27)  Purification, characterization, and cDNA cloning of acidic platelet aggregation inhibiting phospholipases A(2) from the snake venom of Vipera lebetina (Levantine viper)..  Toxicon : official journal of the International Society on Toxinology,  54  ((4)):  (429-439).  [PMID:19467252]
12. Daniela P Marchi-Salvador,Carlos A H Fernandes,Lucas B Silveira,Andreimar M Soares,Marcos R M Fontes.  (2009-07-21)  Crystal structure of a phospholipase A(2) homolog complexed with p-bromophenacyl bromide reveals important structural changes associated with the inhibition of myotoxic activity..  Biochimica et biophysica acta,  1794  ((11)):  (1583-1590).  [PMID:19616648]
13. Mark Merchant,Raphiel Heard,Caleb Monroe.  (2009-07-31)  Characterization of phospholipase A(2) activity in serum of the American alligator (Alligator mississippiensis)..  Journal of experimental zoology. Part A, Ecological genetics and physiology,  311  ((9)):  (662-666).  [PMID:19642205]
14. Sandeep Ravindran,Melissa B Lodoen,Steven H L Verhelst,Matthew Bogyo,John C Boothroyd.  (2009-12-04)  4-Bromophenacyl bromide specifically inhibits rhoptry secretion during Toxoplasma invasion..  PloS one,  4  ((12)):  (e8143-e8143).  [PMID:19956582]
15. Sony Shrestha,Yonggyun Kim.  (2010-02-04)  Biochemical characteristics of immune-associated phospholipase A(2) and its inhibition by an entomopathogenic bacterium, Xenorhabdus nematophila..  Journal of microbiology (Seoul, Korea),  47  ((6)):  (774-782).  [PMID:20127473]
16. Markus Berger,José Reck,Renata M S Terra,Walter O Beys da Silva,Lucélia Santi,Ant?nio F M Pinto,Marilene H Vainstein,Carlos Termignoni,Jorge A Guimar?es.  (2010-02-17)  Lonomia obliqua venomous secretion induces human platelet adhesion and aggregation..  Journal of thrombosis and thrombolysis,  30  ((3)):  (300-310).  [PMID:20157842]
17. Karinne Cristinne da Silva Cunha,André Lopes Fuly,Elizabeth Giestal de Araujo.  (2011-01-13)  A phospholipase A? isolated from Lachesis muta snake venom increases the survival of retinal ganglion cells in vitro..  Toxicon : official journal of the International Society on Toxinology,  57  ((4)):  (580-585).  [PMID:21223976]
18. Daniel I Perez, Valle Palomo, Concepción Pérez, Carmen Gil, Pablo D Dans, F Javier Luque, Santiago Conde, Ana Martínez,.  (2011-04-20)  Switching reversibility to irreversibility in glycogen synthase kinase 3 inhibitors: clues for specific design of new compounds..  Journal of medicinal chemistry,  54  ((12)):  ( 4042-4056 ).  [PMID:21500862]
19. Zhuo-Jia Chen,Xue-Ding Wang,Hong-Sheng Wang,Shu-da Chen,Lie-Min Zhou,Jia-Li Li,Wen-Ying Shu,Jue-Qian Zhou,Zi-Yan Fang,Yu Zhang,Min Huang.  (2011-11-08)  Simultaneous determination of valproic acid and 2-propyl-4-pentenoic acid for the prediction of clinical adverse effects in Chinese patients with epilepsy..  Seizure,  21  ((2)):  (110-117).  [PMID:22055352]
20. He-ying Liu,Li Ding,Yong Yu,Yan Chu,He Zhu.  (2012-03-21)  Comparison of three derivatization reagents for the simultaneous determination of highly hydrophilic pyrimidine antitumor agents in human plasma by LC-MS/MS..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  893-894  ():  (49-56).  [PMID:22429875]
21. Rafael M Ximenes,Renata S Alves,Ticiana P Pereira,Renata M Araújo,Edilberto R Silveira,Marcelo M Rabello,Marcelo Z Hernandes,Veronica C G Soares,Daniel Bristot,Camila L Pires,Daniela O Toyama,Henrique H Gaeta,Helena S A Monteiro,Marcos H Toyama.  (2012-08-29)  Harpalycin 2 inhibits the enzymatic and platelet aggregation activities of PrTX-III, a D49 phospholipase A2 from Bothrops pirajai venom..  BMC complementary and alternative medicine,  12  ():  (139-139).  [PMID:22925825]
22. Mariana A P Rodrigues,Lourdes Dias,André L Rennó,Norma C Sousa,Adriana Smaal,Delano A da Silva,Stephen Hyslop.  (2014-06-29)  Rat atrial responses to Bothrops jararacussu (jararacu?u) snake venom..  Toxicology,  323  ():  (109-124).  [PMID:24973630]
23. Wan Chen,Leng Chuan Goh,Tse Siang Kang,R Manjunatha Kini.  (2014-07-11)  Identification and characterisation of novel inhibitors on extrinsic tenase complex from Bungarus fasciatus (banded krait) venom..  Thrombosis and haemostasis,  112  ((4)):  (700-715).  [PMID:25008365]
24. Jordan Doumanov,Kirilka Mladenova,Tanya Topouzova-Hristova,Stoyanka Stoitsova,Svetla Petrova.  (2014-12-24)  Effects of vipoxin and its components on HepG2 cells..  Toxicon : official journal of the International Society on Toxinology,  94  ():  (36-44).  [PMID:25534906]
25. J Fohlman,D Eaker,M J Dowdall,R Lüllmann-Rauch,T Sj?din,S Leander.  (1979-03-01)  Chemical modification of taipoxin and the consequences for phospholipase activity, pathophysiology, and inhibition of high-affinity choline uptake..  European journal of biochemistry,  94  ((2)):  (531-540).  [PMID:428399]
26. H M Verheij,J J Volwerk,E H Jansen,W C Puyk,B W Dijkstra,J Drenth,G H de Haas.  (1980-02-19)  Methylation of histidine-48 in pancreatic phospholipase A2. Role of histidine and calcium ion in the catalytic mechanism..  Biochemistry,  19  ((4)):  (743-750).  [PMID:7356955]
27. C C Yang,K King.  (1980-08-07)  Chemical modification of the histidine residue in basic phospholipase A2 from the venom of Naja nigricollis..  Biochimica et biophysica acta,  614  ((2)):  (373-388).  [PMID:7407195]
28. Adriana G Martins,Jorgete Constantin,Fabrício Bracht,Ana Maria Kelmer-Bracht,Adelar Bracht.  (2006-05-03)  The action of extracellular NAD+ on gluconeogenesis in the perfused rat liver..  Molecular and cellular biochemistry,  286  ((1-2)):  (115-124).  [PMID:16652226]
29. Mohammad Tariq,Ibrahim Elfaki,Haseeb-Ahmad Khan,Mohammad Arshaduddin,Samia Sobki,Meshal Al Moutaery.  (2006-09-29)  Bromophenacyl bromide, a phospholipase A2 inhibitor attenuates chemically induced gastroduodenal ulcers in rats..  World journal of gastroenterology,  12  ((36)):  (5798-5804).  [PMID:17007045]
30. Wen-Hsin Liu,Pei-Hsiu Kao,Yi-Ling Chiou,Shinne-Ren Lin,Ming-Jung Wu,Long-Sen Chang.  (2009-01-03)  Catalytic activity-independent pathway is involved in phospholipase A(2)-induced apoptotic death of human leukemia U937 cells via Ca(2+)-mediated p38 MAPK activation and mitochondrial depolarization..  Toxicology letters,  185  ((2)):  (102-109).  [PMID:19118607]

相关文档

质检报告COA

请输入批号:


 SDS中文版  SDS英文版

 质量技术规格说明书

产品问答

产品问答

登录提交问题 Hover me 请先登录再提交问题
查看全部
您提交该产品问题后,我们会在1-2个工作日内给您答复,您可以登录"我的账号",然后点击"我的产品问答"查看答案
上海阿拉丁生化科技股份有限公司
销售条款及条件 ? ? ? ? 隐私政策
? 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任
沪公网安备 31012002004058号 沪ICP备09093490号-2

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。

上海工商 危险品化学品经营许可证（带存储）营业执照(三证合一)

91高清自产国产拍,无码免费A级毛片大全,日本 欧美 国产中文字幕,99re热视频这里只有精品视频首页

品牌简介

{转码主词}