首页
400-620-6333
切换导航
搜索
基本描述
| 英文名称 | CGP 12177 hydrochloride |
|---|---|
| 英文别名 | 4-[3-(tert-butylamino)-2-hydroxypropoxy]-1,3-dihydrobenzimidazol-2-one hydrochloride |
| 储存温度 | 室温 |
| 运输条件 | 常规运输 |
| 产品介绍 |
CGP 12177盐酸盐是一种β1-AR和β2-AR肾上腺素受体拮抗剂。也非常规地表现为β3-AR部分激动剂。 CGP 12177 hydrochloride is a β1-AR and β2-AR adrenoreceptor antagonist. Also behaves non-conventionally as a β3-AR partial agonist. |
产品属性
| Ki Data | β1-AR: Ki= 0.9 nM; β2-AR : Ki= 4 nM; β3-AR: Ki= 88 nM |
|---|---|
| IC50 | β3-AR: EC5050 = 2 μM (human) |
名称和标识符
| IUPAC Name | 4-[3-(tert-butylamino)-2-hydroxypropoxy]-1,3-dihydrobenzimidazol-2-one |
|---|---|
| INCHI | InChI=1S/C14H21N3O3/c1-14(2,3)15-7-9(18)8-20-11-6-4-5-10-12(11)17-13(19)16-10/h4-6,9,15,18H,7-8H2,1-3H3,(H2,16,17,19) |
| InChi Key | UMQUQWCJKFOUGV-UHFFFAOYSA-N |
| Canonical SMILES | CC(C)(C)NCC(COC1=CC=CC2=C1NC(=O)N2)O |
| WGK Germany | 3 |
| RTECS | DE2565000 |
| 关联CAS | 81047-99-6 |
| PubChem CID | 2687 |
| MeSH Entry Terms | 4-(3-tert-butylamino-2-hydroxypropoxy)benzimidazol-2-one;4-(3-tert-butylamino-2-hydroxypropoxy)benzimidazol-2-one hydrochloride, (+-)-isomer;4-(3-tert-butylamino-2-hydroxypropoxy)benzimidazol-2-one, (+-)-isomer;4-(3-tert-butylamino-2-hydroxypropoxy)benzim |
| 分子量 | 315.8 |
数据库链接
| PubChem CID | 2687 |
|---|---|
| ChEBI | CHEBI:73288 |
| ChEMBL Ligand | CHEMBL420746 |
| CAS Registry No. | 81047-99-6 |
| GPCRdb Ligand | CGP 12177 |
化学和物理性质
| 溶解性 | Soluble in water (50 mM), and DMSO (>10 mg/ml). |
|---|---|
| 折光率 | n20D~1.55 (Predicted) |
| 熔点 | 258-260° C |
安全和危险性（GHS）
| WGK Germany | 3 |
|---|---|
| RTECS | DE2565000 |
关联配体
| Ligand ID | 532 |
|---|---|
| 名称 | CGP 12177 |
| 别名 | CGP 12177A |
| 类别 | Synthetic organic |
| 学名 | 4-[3-(tert-butylamino)-2-hydroxypropoxy]-1,3-dihydrobenzimidazol-2-one |
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| 评价 | Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth. |
产品问答
产品问答
上海阿拉丁生化科技股份有限公司
? 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任
危险品化学品经营许可证（带存储）