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克拉屈滨

诱导DNA双链断裂的核苷类似物。腺苷脱氨酶抑制剂

规格或纯度: ≥98%

CAS编号: 4291-63-8
分子式: C₁₀H₁₂ClN₅O₃
分子量: 285.69
MDL号: MFCD00153939
PubChem编号: 20279

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货号 (SKU)	包装规格	是否现货	价格	数量
C129833-10mg	10mg	现货
C129833-50mg	50mg	现货
C129833-100mg	100mg	现货
C129833-250mg	250mg	现货
C129833-1g	1g	现货

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六元杂环化合物嘧啶类

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基本描述

规格或纯度	≥98%
英文名称	Cladribine
别名	CdA\|克拉利宾\|2-氯-2'-脱氧腺嘌呤核苷\|2-氯-9-(2-脱氧-β-D-呋喃阿拉伯糖基)腺嘌呤
英文别名	Cladribine\|2-Chloro-2'-deoxyadenosine\|4291-63-8\|Leustatin\|2-Chlorodeoxyadenosine\|2-CdA\|Chlorodeoxyadenosine\|Litak\|ADENOSINE, 2-CHLORO-2'-DEOXY-\|CldAdo\|2-Chloro-2'-deoxy-beta-adenosine\|mavenclad\|Cladaribine\|2CdA\|RWJ 26251\|2-chloro-deoxyadenosine\|2ClAdo\|RWJ
生化机理	Deoxyadenosine analog resistant to adenosine deaminase; antileukemic with immunosuppressive activity
应用	It is a chlorinated purine nucleoside with activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL) and multiple myeloma (MM). 2-CdA resists ADA degradation and is phosphorylated to CdATP in lymphocytes. CdATP incorporation into DNA induces strand breaks and the activation of apoptosis. 2-CdA may also be used in studies involving the inhibition of DNA polymerase(s). Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK).
储存温度	2-8°C储存
运输条件	冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	Cladribine是一种腺苷脱氨酶抑制剂，作用于U266， RPMI8226，和MM1.S细胞，IC50分别约为2.43 μM， 0.75 μM，和0.18 μM。最大吸收波长265(EtOH aq.) nm Cladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively It is a chlorinated purine nucleoside with activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL) and multiple myeloma (MM). 2-CdA resists ADA degradation and is phosphorylated to CdATP in lymphocytes. CdATP incorporation into DNA induces strand breaks and the activation of apoptosis. 2-CdA may also be used in studies involving the inhibition of DNA polymerase(s). Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK).

名称和标识符

IUPAC Name	(2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
INCHI	InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
InChi Key	PTOAARAWEBMLNO-KVQBGUIXSA-N
Canonical SMILES	C1C(C(OC1N2C=NC3=C(N=C(N=C32)Cl)N)CO)O
RTECS	AU7357560
PubChem CID	20279
分子量	285.69
Reaxy-Rn	624220

数据库链接

DrugBank Ligand	DB00242
PubChem CID	20279
CAS Registry No.	4291-63-8
ChEMBL Ligand	CHEMBL1619
Wikipedia	Cladribine
RCSB PDB Ligand	CL9
DrugCentral Ligand	667

化学和物理性质

溶解性	Soluble in DMSO ( ≥57 mg/ml), water (<1 mg/ml), ethanol (<1 mg/ml), and methanol.
敏感性	对热敏感
熔点	220°C

安全和危险性（GHS）

象形图	Toxic Harmful
信号词	Danger
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation H301: Toxic if swallowed H311: Toxic in contact with skin H331: Toxic if inhaled
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P361+P364,P264+P265,P301+P316,P337+P317,P332+P317,P316,P319
RTECS	AU7357560
Reaxy-Rn	624220
Merck Index	2337

关联配体

Ligand ID	4799
名称	cladribine
别名	Leustatin®
类别	Synthetic organic
学名	(2R,3S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Cladribine is a purine (adenosine) analogue and an antineoplastic and immunosuppressant agent

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