L-肌肽

规格或纯度: 98%

CAS编号: 305-84-0
分子式: C₉H₁₄N₄O₃
分子量: 226.23
Beilstein号: 87671
EC号: 206-169-9
MDL号: MFCD00005207
PubChem编号: 439224

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货号 (SKU)	包装规格	是否现货
C106843-1g	1g	现货
C106843-5g	5g	现货
C106843-25g	25g	现货
C106843-100g	100g	现货

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五元杂环化合物咪唑类

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基本描述

规格或纯度	98%
英文名称	L-Carnosine
别名	N-β-丙氨酰-L-组氨酸；β-丙氨酰-L-组氨酸；L-肉缩氨基酸
英文别名	β-Alanyl-L-histidine; L-Ignotine; N-beta-Alanyl-L-histidine
生化机理	L-Carosine is a dipeptide found at millimolar concentration in brain, muscle and the lens of the eye. In model systems it is a potent antioxidant that scavenges oxygen free radicals and transition metal ions. It blocks protein-protein and protein-DNA cross-links induced by hypochlorite anions and toxic aldehydes such as acetaldehyde, formaldehyde, and malondialdehyde, the primary product of lipid peroxidation. It also inhibits nonenzymatic protein glycation induced by aldose and ketose reducing sμgars and inhibits the formation of toxic advanced glycation end products (AGE). These activities make it of interest in studies of aging, atherosclerosis, Alzheimer′s disease, and the secondary effects of diabetes.
应用	二肽，具潜在的抗氧剂和抗糖基化活性；阻止乙醛诱导的非酶糖基化和蛋白质偶联。也是肌肽酶检测的底物。具细胞抗氧化，维持机体pH平衡，延长细胞寿命。
储存温度	-20°C储存,充氩
运输条件	超低温冰袋运输
产品介绍	L-肌肽是一种二肽，以毫摩尔浓度出现在大脑、肌肉和眼睛的晶状体上。二肽，具潜在的抗氧剂和抗糖基化活性；阻止乙醛诱导的非酶糖基化和蛋白质偶联。也是肌肽酶检测的底物。具细胞抗氧化，维持机体pH平衡，延长细胞寿命。 Carnosine is an antioxidant. Inhibits soluble guanylyl cyclase (sGC) by interacting with the heme iron to form a chelate complex. An antioxidant soluble guanylyl cyclase inhibitor.

名称和标识符

EC号	206-169-9
IUPAC Name	(2S)-2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
INCHI	InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1
InChi Key	CQOVPNPJLQNMDC-ZETCQYMHSA-N
Canonical SMILES	C1=C(NC=N1)CC(C(=O)O)NC(=O)CCN
分子式	C₉H₁₄N₄O₃
关联CAS	305-84-0,1370422-07-3
UNII	8HO6PVN24W
PubChem CID	439224
Beilstein号	87671
分子量	226.23

数据库链接

ChEBI	CHEBI:15727
Wikipedia	Carnosine
CAS Registry No.	305-84-0
PubChem CID	439224
ChEMBL Ligand	CHEMBL242948
RCSB PDB Ligand	8V0

化学和物理性质

溶解性	Soluble in 80% acetic acid (10 mg/ml), and water (1:3.1).
密度	1.375
敏感性	易吸潮;对空气敏感
熔点	253°C
比旋光度	21 ° (C=2, H2O)

安全信息

WGK Germany	2
RTECS	MS3080000
Reaxy-Rn	87671
Merck Index	1850
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

关联配体

Ligand ID	4559
名称	carnosine
别名	β-alanyl-L-histidine
类别	Metabolite
学名	(2S)-2-(3-aminopropanamido)-3-(1H-imidazol-4-yl)propanoic acid
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth.

参考文献

1. Yuko Horii,Jiao Shen,Yoshiyuki Fujisaki,Kokichi Yoshida,Katsuya Nagai. (2012-01-14) Effects of L-carnosine on splenic sympathetic nerve activity and tumor proliferation.. Neuroscience letters, 510 ((1)): (1-5). [PMID:22240100]
2. Katsuya Nagai,Mamoru Tanida,Akira Niijima,Nobuo Tsuruoka,Yoshinobu Kiso,Yuko Horii,Jiao Shen,Nobuaki Okumura. (2012-03-01) Role of L-carnosine in the control of blood glucose, blood pressure, thermogenesis, and lipolysis by autonomic nerves in rats: involvement of the circadian clock and histamine.. Amino acids, 43 ((1)): (97-109). [PMID:22367578]
3. John Caruso,Jessica Charles,Kayla Unruh,Rachel Giebel,Lexis Learmonth,William Potter. (2012-08-02) Ergogenic effects of β-alanine and carnosine: proposed future research to quantify their efficacy.. Nutrients, 4 ((7)): (585-601). [PMID:22852051]
4. Inge Everaert,Sanne Stegen,Bert Vanheel,Youri Taes,Wim Derave. (2012-08-17) Effect of beta-alanine and carnosine supplementation on muscle contractility in mice.. Medicine and science in sports and exercise, 45 ((1)): (43-51). [PMID:22895378]
5. Jing Ma,Jia-Yan Xiong,Wei-Wei Hou,Hai-Jing Yan,Yun Sun,Shang-Wei Huang,Le Jin,Ye Wang,Wei-Wei Hu,Zhong Chen. (2012-09-05) Protective effect of carnosine on subcortical ischemic vascular dementia in mice.. CNS neuroscience & therapeutics, 18 ((9)): (745-753). [PMID:22943141]
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14. Francesco Attanasio,Marino Convertino,Andrea Magno,Amedeo Caflisch,Alessandra Corazza,Haritha Haridas,Gennaro Esposito,Sebastiano Cataldo,Bruno Pignataro,Danilo Milardi,Enrico Rizzarelli. (2013-02-27) Carnosine inhibits Aβ(42) aggregation by perturbing the H-bond network in and around the central hydrophobic cluster.. Chembiochem : a European journal of chemical biology, 14 ((5)): (583-592). [PMID:23440928]
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17. Hyuk Soon Choi,Ji-Youn Lim,Hoon Jai Chun,Min Lee,Eun Sun Kim,Bora Keum,Yeon Seok Seo,Yoon-Tae Jeen,Soon Ho Um,Hong Sik Lee,Chang Duck Kim,Ho Sang Ryu,Donggeun Sul. (2013-06-08) The effect of polaprezinc on gastric mucosal protection in rats with ethanol-induced gastric mucosal damage: comparison study with rebamipide.. Life sciences, 93 ((2-3)): (69-77). [PMID:23743168]
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20. Zuzana Ditte,Peter Ditte,Martina Labudova,Veronika Simko,Filippo Iuliano,Miriam Zatovicova,Lucia Csaderova,Silvia Pastorekova,Jaromir Pastorek. (2014-06-03) Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts.. BMC cancer, 14 (): (358-358). [PMID:24886661]
21. Seung-Hoon Baek,Ah Reum Noh,Kyeong-A Kim,Muhammad Akram,Young-Jun Shin,Eun-Sun Kim,Seong Woon Yu,Arshad Majid,Ok-Nam Bae. (2014-06-19) Modulation of mitochondrial function and autophagy mediates carnosine neuroprotection against ischemic brain damage.. Stroke, 45 ((8)): (2438-2443). [PMID:24938837]
22. Seh Hyon Song,Kyung Min Lee,Jong Boo Kang,Sang Gon Lee,Myung Joo Kang,Young Wook Choi. (2014-08-05) Improved skin delivery of voriconazole with a nanostructured lipid carrier-based hydrogel formulation.. Chemical & pharmaceutical bulletin, 62 ((8)): (793-798). [PMID:25087631]
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25. Sang Gon Lee,Sung Rae Kim,Hye In Cho,Mean Hyung Kang,Dong Woo Yeom,Seo Hyun Lee,Sangkil Lee,Young Wook Choi. (2014-10-03) Hydrogel-based ultra-moisturizing cream formulation for skin hydration and enhanced dermal drug delivery.. Biological & pharmaceutical bulletin, 37 ((10)): (1674-1682). [PMID:25273390]
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27. Sanne Stegen,Inge Everaert,Louise Deldicque,Silvia Vallova,Barbora de Courten,Barbara Ukropcova,Jozef Ukropec,Wim Derave. (2015-03-25) Muscle histidine-containing dipeptides are elevated by glucose intolerance in both rodents and men.. PloS one, 10 ((3)): (e0121062-e0121062). [PMID:25803044]
28. Michael Piper,Aih Cheun Lee,Francisca P G van Horck,Heather McNeilly,Trina Bo Lu,William A Harris,Christine E Holt. (2015-04-18) Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones.. Neural development, 10 (): (3-3). [PMID:25886013]
29. Sofya Suidasari,Tomoko Hasegawa,Noriyuki Yanaka,Norihisa Kato. (2015-06-24) Dietary supplemental vitamin B6 increases carnosine and anserine concentrations in the heart of rats.. SpringerPlus, 4 (): (280-280). [PMID:26101732]
30. Megumi Kato,Taichi Yamazaki,Hisashi Kato,Sakae Eyama,Mari Goto,Mariko Yoshioka,Akiko Takatsu. (2015-08-11) Development of High-purity Certified Reference Materials for 17 Proteinogenic Amino Acids by Traceable Titration Methods.. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 31 ((8)): (805-814). [PMID:26256605]
31. Yong Guo,Chenjun Guo,Wenjing Ha,Zhenhua Ding. (2019-04-02) Carnosine improves diabetic retinopathy via the MAPK/ERK pathway.. Experimental and therapeutic medicine, 17 ((4)): (2641-2647). [PMID:30930967]
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33. Marie-France Palin,Jér?me Lapointe,Claude Gariépy,Danièle Beaudry,Claudia Kalbe. (2020-09-19) Characterisation of intracellular molecular mechanisms modulated by carnosine in porcine myoblasts under basal and oxidative stress conditions.. PloS one, 15 ((9)): (e0239496-e0239496). [PMID:32946513]
34. Bowen Lou,Mike Boger,Katrin Bennewitz,Carsten Sticht,Stefan Kopf,Jakob Morgenstern,Thomas Fleming,Rüdiger Hell,Zuyi Yuan,Peter Paul Nawroth,Jens Kroll. (2020-09-28) Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans.. Redox biology, 37 (): (101723-101723). [PMID:32980661]
35. Yadi Cao,Juan Xu,Di Cui,Lei Liu,Shiqi Zhang,Bing Shen,Yonggui Wu,Qiu Zhang. (2020-12-06) Protective effect of carnosine on hydrogen peroxide-induced oxidative stress in human kidney tubular epithelial cells.. Biochemical and biophysical research communications, 534 (): (576-582). [PMID:33276949]
36. T Matsukura,H Tanaka. (2000-08-22) Applicability of zinc complex of L-carnosine for medical use.. Biochemistry. Biokhimiia, 65 ((7)): (817-823). [PMID:10951100]
37. Mark A Babizhayev,Yegor E Yegorov. (2010-09-25) Advanced drug delivery of N-acetylcarnosine (N-acetyl-beta-alanyl-L-histidine), carcinine (beta-alanylhistamine) and L-carnosine (beta-alanyl-L-histidine) in targeting peptide compounds as pharmacological chaperones for use in tissue engineering, human disease management and therapy: from in vitro to the clinic.. Recent patents on drug delivery & formulation, 4 ((3)): (198-230). [PMID:20863274]
38. T L Dutka,C R Lamboley,M J McKenna,R M Murphy,G D Lamb. (2011-12-17) Effects of carnosine on contractile apparatus Ca2? sensitivity and sarcoplasmic reticulum Ca2? release in human skeletal muscle fibers.. Journal of applied physiology (Bethesda, Md. : 1985), 112 ((5)): (728-736). [PMID:22174397]
39. A S B Goebel,G Schmaus,R H H Neubert,J Wohlrab. (2012-08-15) Dermal peptide delivery using enhancer molecules and colloidal carrier systems--part I: carnosine.. Skin pharmacology and physiology, 25 ((6)): (281-287). [PMID:22890441]
40. Johann Edge,Nir Eynon,Michael J McKenna,Craig A Goodman,Roger C Harris,David J Bishop. (2012-08-28) Altering the rest interval during high-intensity interval training does not affect muscle or performance adaptations.. Experimental physiology, 98 ((2)): (481-490). [PMID:22923232]
41. Latif Abbaso?lu,Esra Betül Kalaz,Merva Soluk-Tekke?in,Vakur Olga?,Semra Do?ru-Abbaso?lu,Müjdat Uysal. (2012-09-11) Beneficial effects of taurine and carnosine in experimental ischemia/reperfusion injury in testis.. Pediatric surgery international, 28 ((11)): (1125-1131). [PMID:22961384]
42. Adalberto Federici,Giovanni Federici,Massimo Milani. (2012-09-27) An urea, arginine and carnosine based cream (Ureadin Rx Db ISDIN) shows greater efficacy in the treatment of severe xerosis of the feet in Type 2 diabetic patients in comparison with glycerol-based emollient cream. A randomized, assessor-blinded, controlled trial.. BMC dermatology, 12 (): (16-16). [PMID:23009311]
43. Marina Scalia,Cristina Satriano,Rossana Greca,Anna Maria Giuffrida Stella,Enrico Rizzarelli,Vittoria Spina-Purrello. (2012-09-27) PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells.. Neurochemical research, 38 ((1)): (50-58). [PMID:23011206]
44. Esra Betül Kalaz,Betül Evran,Seval Develi-??,Pervin Vural,Semra Dogru-Abbasoglu,Müjdat Uysal. (2012-10-20) Effect of carnosine on prooxidant-antioxidant balance in several tissues of rats exposed to chronic cold plus immobilization stress.. Journal of pharmacological sciences, 120 ((2)): (98-104). [PMID:23079503]
45. Ok-Nam Bae,Kelsey Serfozo,Seung-Hoon Baek,Ki Yong Lee,Anne Dorrance,Wilson Rumbeiha,Scott D Fitzgerald,Muhammad U Farooq,Bharath Naravelta,Archit Bhatt,Arshad Majid. (2012-12-20) Safety and efficacy evaluation of carnosine, an endogenous neuroprotective agent for ischemic stroke.. Stroke, 44 ((1)): (205-212). [PMID:23250994]
46. M G Makletsova,T N Fedorova,M Yu Maksimova,A A Boldyrev. (2013-01-19) Effects of carnosine on polyamine levels in red blood cells of patients with hypertonic discirculatory encephalopathy.. Bulletin of experimental biology and medicine, 154 ((2)): (210-212). [PMID:23330127]
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53. Dai Mizuno,Keiko Konoha-Mizuno,Miwako Mori,Yutaka Sadakane,Hironari Koyama,Susumu Ohkawara,Masahiro Kawahara. (2015-04-08) Protective activity of carnosine and anserine against zinc-induced neurotoxicity: a possible treatment for vascular dementia.. Metallomics : integrated biometal science, 7 ((8)): (1233-1239). [PMID:25846004]
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L-肌肽

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L-肌肽

库存信息

库存信息

库存信息

库存信息

基本描述

名称和标识符

数据库链接

化学和物理性质

安全信息

关联配体

参考文献

相关文档

质检报告COA

相关技术文章

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