| 规格或纯度 | 来自短费尔德青霉（Penicillium brefeldianum）的现成溶液,10mg/mL in DMSO |
|---|---|
| 英文名称 | Brefeldin A |
| 英文别名 | BFA, Cyanein, Ascotoxin, γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone, Decumbin |
| 生化机理 | 布雷菲德菌素A（BFA）是一种会破坏高尔基体的结构和功能的真菌代谢产物。BFA是鞘磷脂循环的一种激活剂。已在人类肿瘤细胞中观察到了布雷菲德菌素A介导的细胞凋亡。Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus by inhibiting transport of proteins from ER to Golgi and inducing retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum. BFA inhibits the transport of sphingomyelin to the surface of mammalian cells. The ester derivatives of BFA exhibit anti-cancer properties. |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
Description Brefeldin A produced fromPenicillium brefeldianummay be used to study protein and lipid transport between Golgi complex and the cell surface. |
| IUPAC Name | (1R,2R,3E,7S,11E,13S,15S)-2,15-dihydroxy-7-methyl-6-oxabicyclo[11.3.0]hexadeca-3,11-dien-5-one |
|---|---|
| INCHI | InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1 |
| InChi Key | KQNZDYYTLMIZCT-KQPMLPITSA-N |
| Canonical SMILES | CC1CCCC=CC2CC(CC2C(C=CC(=O)O1)O)O |
| WGK Germany | 3 |
| RTECS | GY8410000 |
| PubChem CID | 5287620 |
| UN Number | 2811 |
| 分子量 | 280.36 |
| Beilstein号 | 25191 |
| 溶解性 | ?DMSO：10mg/mL |
|---|---|
| 比旋光度 | 93° (C=2,MeOH) |
| 熔点 | 201-205°C |
| 象形图 |
Toxic |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H301: Toxic if swallowed |
| 预防措施声明 | P301+P310 |
| WGK Germany | 3 |
| RTECS | GY8410000 |
| Merck Index | 1369 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Faceshields,Gloves |
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