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Avelumab (anti-PD-L1)

规格或纯度: Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

种属反应性: Cynomolgus,Dog?,Human,Mouse?,Rabbit?,Rat?
亚型: Human IgG1

有货

库存信息

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库存信息

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库存信息

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货号 (SKU)	包装规格	是否现货
A412006-1mg	1mg	现货
A412006-5mg	5mg	现货
A412006-10mg	10mg	期货

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基本信息

产品名称	Avelumab (anti-PD-L1)
规格或纯度	Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
特异性	B7-H1 / PD-L1 / CD274
应用	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
反应种属	Cynomolgus,Dog?,Human,Mouse?,Rabbit?,Rat?
偶联标记	Unconjugated

产品属性

抗体类型	Primary antibody
Format	Whole IgG
亚型	Human IgG1
轻链亚型	Lambda
SDS-PAGE	28.7 kDa (Light Chain) & 50.1 kDa (Heavy Chain), under reducing conditions; 182.4 kDa, under non-reducing conditions.
纯化方法	Protein A purified
来源	CHO supernatant
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	Lot by Lot
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -80℃ for 18 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS编号和信息	1537032-82-8

数据库链接

IMGT/mAb-DB	512

关联配体

Ligand ID	8735
名称	avelumab
别名	MSB0010718C
类别	Antibody
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	A patent search identifies that peptide sequences of the heavy and light chains of avelumab are identical to SEQ ID NO: 24 and SEQ ID NO: 25 (respectively) in WO2013079174 A1 . The data in the table below is that proovided for clone A09-246-2, a preferred embodiment of the patent.
评价	Avelumab is a programmed death-ligand 1 (PD-L1; CD274) blocking human IgG1 lambda monoclonal antibody . It is the first drug approved for the treatment of Merkel cell carcinoma (MCC). Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record.
配体家族	Immune checkpoint modulators
单字母多肽序列
三字母多肽序列
翻译后修饰
化学修饰

参考文献

1. Pardoll DM. (2012) The blockade of immune checkpoints in cancer immunotherapy.. Nat Rev Cancer, 12 (4): (252-64). [PMID:22437870]
2. Topalian SL, Drake CG, Pardoll DM. (2015) Immune checkpoint blockade: a common denominator approach to cancer therapy.. Cancer Cell, 27 (4): (450-61). [PMID:25858804]

图片

Flow Cytometry: Avelumab (anti-PD-L1) (A412006)

Avelumab (anti-PD-L1) (A412006) - Flow Cytometry
Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood lymphocytes labelling PD-L1 with Avelumab (anti-PD-L1) (A412006) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156250).

Flow Cytometry: Avelumab (anti-PD-L1) (A412006)

Avelumab (anti-PD-L1) (A412006) - Flow Cytometry
Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood lymphocytes labelling PD-L1 (red) with Avelumab (anti-PD-L1) (A412006) conjugated with biotin and detected with SA-PE (rp156250). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.