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阿特珠单抗（抗PD-L1）

Atezolizumab 是一种人源化单克隆抗体 IgG1，抵抗程序性死亡因子配体1 (PD-L1)，用于癌症研究。
规格或纯度: ~60mg/ml（in buffer）,98%
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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
A411996-1mg 1mg 现货 Stock Image
A411996-5mg 5mg 现货 Stock Image
A411996-10mg 10mg 现货 Stock Image
A411996-25mg 25mg 现货 Stock Image
A411996-100mg 100mg 现货 Stock Image
大包装询价 添加到收藏夹 比较
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基本描述

规格或纯度 ~60mg/ml（in buffer）,98%
英文名称 Atezolizumab (anti-PD-L1)
别名 阿替利珠单抗
英文别名 MPDL3280A
储存温度 避光,-20°C储存
运输条件 超低温冰袋运输
产品介绍

产品介绍：

蛋白原液 。每种装于冻存管中，单抗质量为标示数量1MG或者5MG，体积根据其浓度不同略有不同。

使用前可以根据自己实验需求进行稀释，溶剂建议用去离子无菌水(细胞培养用水))或者PBS，
不建议使用含有防腐成分的稀释液进行稀释，会增加细胞或者动物毒性。
稀释前，计算加入多少体积溶剂，请参考购买批次质检单上蛋白浓度，
举例，质检单显示该批次单抗蛋白原液蛋白浓度为 50mg/ml
对应5MG包装的蛋白原液体积为5mg（质量）/50mg/ml(浓度)=0.1ML，
实验需求蛋白浓度为10mg/ml, 需要稀释倍数为 50/10=5, 则需要加入0.4ML,即400ul PBS或者无菌去离子水即可。
若给药量为固定质量值，比如单次给药0.5MG，对应蛋白原液给药体积为10ul，建议稀释后，提高给药体积降低误差，因为注射器或者移液器吸头残留会影响实验效果。

Non-reduced CE-SDS:………………………………………….>90%;
SEC-HPLC:………………………………………………………….>95%;
Bacterial Endotoxins Test：…………………………………. .<10EU/ml
Residual Proteins of Host Cell: ……………………………. <100 ng/mg
Exogenous residual DNA: …………………………………. . <100pg/mg
Residual Protein A: ……………………………………………. .<100 ng/mg
Biological Activity:………………………………………….……. .80% to 125% of standard


产品描述：
一种针对蛋白配体PD-L1（程序性细胞死亡-1配体1）的人Fc优化单克隆抗体，具有潜在的免疫检查点抑制和抗肿瘤活性。Atezolizumab与PD-L1结合，阻断其与活化T细胞上表达的受体程序性死亡1（PD-1）的结合和激活，这可能增强T细胞介导的肿瘤免疫反应并逆转T细胞失活。此外，通过与PD-L1结合，atezolizumab还阻止该配体与活化T细胞上表达的B7.1结合，这进一步增强了T细胞介导的免疫应答。PD-L1在许多人类癌症细胞类型和各种肿瘤浸润免疫细胞上过度表达。PD-L1与T细胞上的PD-1结合抑制免疫系统并导致免疫逃避增加。PD-1是一种跨膜蛋白，是免疫系统的负调节因子，限制CD8+T细胞的扩增和存活。atezolizumab的Fc区被修饰成既不会诱导抗体依赖性细胞毒性（ADCC），也不会诱导补体依赖性细胞毒（CDC）。

Product introduction:

Protein stock solution. Each type of McAb is packed in a frozen storage tube, and its mass is 1MG or 5MG, and its volume is slightly different according to its concentration.
Before use, it can be diluted according to its own experimental needs. The solvent is recommended to use deionized sterile water (water for cell culture) or PBS,
It is not recommended to use diluents containing antiseptic ingredients for dilution, which will increase cell or animal toxicity.
Before dilution, calculate the volume of solvent added. Please refer to the protein concentration on the quality inspection sheet of the purchased batch,
For example, the quality inspection document shows that the protein concentration of this batch of monoclonal antibody protein stock solution is 50mg/ml
The volume of protein stock solution corresponding to 5MG package is 5mg (mass)/50mg/ml (concentration)=0.1ML,
The protein concentration required for the experiment is 10mg/ml, and the dilution ratio is 50/10=5, so 0.4ML, namely 400ul PBS or sterile deionized water, is required.
If the dose is a fixed mass value, such as 0.5MG for a single dose, the corresponding dose volume of protein stock solution is 10ul. It is recommended to increase the dose volume after dilution to reduce the error, because the residual syringe or pipette suction head will affect the experimental effect.
Non-reduced CE-SDS:………………………………………….> 90%;
SEC-HPLC:………………………………………………………….> 95%;
Bacterial Endotoxins Test：…………………………………. .< 10EU/ml
Residual Proteins of Host Cell: ……………………………. < 100 ng/mg
Exogenous residual DNA: …………………………………. . < 100pg/mg
Residual Protein A: ……………………………………………. .< 100 ng/mg
Biological Activity:………………………………………….……. . 80% to 125% of standard

Product description:

A human, Fc optimized, monoclonal antibody directed against the protein ligand PD-L1 (programmed cell death-1 ligand 1), with potential immune checkpoint inhibitory and antineoplastic activities. Atezolizumab binds to PD-L1, blocking its binding to and activation of its receptor programmed death 1 (PD-1) expressed on activated T-cells, which may enhance the T-cell-mediated immune response to neoplasms and reverse T-cell inactivation. In addition, by binding to PD-L1, atezolizumab also prevents binding of this ligand to B7.1 expressed on activated T cells, which further enhances the T-cell-mediated immune response. PD-L1 is overexpressed on many human cancer cell types and on various tumor-infiltrating immune cells. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in increased immune evasion. PD-1, a transmembrane protein, is a negative regulator of the immune system that limits the expansion and survival of CD8+ T cells. The Fc region of atezolizumab is modified in such a way that it does not induce either antibody-dependent cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC).

化学和物理性质

稳定性与储存 稀释后的蛋白溶液，可于2-8度冷藏避光保存不超过2周，不建议长期储存。 避免反复冻融，每次冻融蛋白活性会降低约5%左右。
敏感性 对光敏感

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