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鹅膏氨酸

兴奋性激动剂

规格或纯度: ≥95%

CAS编号: 2552-55-8
分子式: C₅H₆N₂O₄
分子量: 158.11
PubChem编号: 1233

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货号 (SKU)	包装规格	是否现货	价格	数量
A137136-1mg	1mg	现货
A137136-5mg	5mg	现货
A137136-10mg	10mg	现货
A137136-25mg	25mg	现货
A137136-50mg	50mg	现货

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mGlu1 receptor Agonist mGlu5 receptor Agonist

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基本描述

别名	α-氨基-3-羟基-5-异噁唑乙酸\|鹅膏蕈氨酸
规格或纯度	≥95%
英文名称	Ibotenic acid
生化机理	神经兴奋性氨基酸，最初是从鹅膏菌中分离出来的。神经毒素通常用于模拟认知功能障碍。NMDA和代谢型受体激动剂。
应用	Ibotenic acid has been used to perform surgery in adult male zebra finches (Taeniopygia guttata) to study reversing reinforcement-induced vocal changes.
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	Ibotenic acid has been used to perform surgery in adult male zebra finches (Taeniopygia guttata) to study reversing reinforcement-induced vocal changes. Ibotenic acid has been used to perform surgery in adult male zebra finches (Taeniopygia guttata) to study reversing reinforcement-induced vocal changes.

名称和标识符

IUPAC Name	2-amino-2-(3-oxo-1,2-oxazol-5-yl)acetic acid
INCHI	InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
InChi Key	IRJCBFDCFXCWGO-UHFFFAOYSA-N
Canonical SMILES	C1=C(ONC1=O)C(C(=O)O)N
PubChem CID	1233
分子量	158.11

数据库链接

PubChem CID	1233
CAS Registry No.	2552-55-8
Wikipedia	Ibotenic_acid
BindingDB Ligand	50004901
ChEMBL Ligand	CHEMBL284895
ChEBI	CHEBI:5854
GPCRdb Ligand	ibotenic acid

化学和物理性质

溶解性	solubility H2O: 1 mg/mL, clear, colorless (with sonication) 0.1 M NaOH: 10.7 mg/mL 0.1 M HCl: 4.7 mg/mL

安全和危险性（GHS）

象形图	Toxic
信号词	Danger
危险声明	H301: Toxic if swallowed
预防措施声明	P321,P405,P501,P264,P270,P330,P301+P316

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参考文献

1. Masini CV et al.. (2012) Auditory cortex lesions do not disrupt habituation of HPA axis responses to repeated noise stress.. Brain Res, 1443 (): (18-26). [PMID:22290179]
2. Murray JE et al.. (2015) Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits.. Nat Commun, 6 (): (10088). [PMID:26657320]
3. Poliwoda A et al.. (2014) Determination of muscimol and ibotenic acid in mushrooms of Amanitaceae by capillary electrophoresis.. Electrophoresis, 35 (18): (2593-9). [PMID:24981810]
4. Hunsaker MR et al.. (2008) Dissociating the roles of dorsal and ventral CA1 for the temporal processing of spatial locations, visual objects, and odors.. Behav Neurosci, 122 (3): (643-50). [PMID:18513134]
5. Guitchounts G et al.. (2020) Encoding of 3D Head Orienting Movements in the Primary Visual Cortex.. Neuron, 108 (3): (512-525.e4). [PMID:32783881]
6. Hunsaker MR & Kesner RP. (2008) Evaluating the differential roles of the dorsal dentate gyrus, dorsal CA3, and dorsal CA1 during a temporal ordering for spatial locations task.. Hippocampus, 18 (9): (955-64). [PMID:18493930]
7. Hunsaker MR et al.. (2008) Evaluating the temporal context of episodic memory: the role of CA3 and CA1.. Behav Brain Res, 188 (2): (310-5). [PMID:18178264]
8. Guirado R et al.. (2016) Evidence for Competition for Target Innervation in the Medial Prefrontal Cortex.. Cereb Cortex, 26 (3): (1287-94). [PMID:26637448]
9. Ruediger S et al.. (2012) Goal-oriented searching mediated by ventral hippocampus early in trial-and-error learning.. Nat Neurosci, 15 (11): (1563-71). [PMID:23001061]
10. Roberts TF et al.. (2012) Motor circuits are required to encode a sensory model for imitative learning.. Nat Neurosci, 15 (10): (1454-9). [PMID:22983208]
11. Tanaka YH et al.. (2018) Thalamocortical Axonal Activity in Motor Cortex Exhibits Layer-Specific Dynamics during Motor Learning.. Neuron, 100 (): (244-258.e12). [PMID:30174116]
12. Hunsaker MR et al.. (2008) The role of the dentate gyrus, CA3a,b, and CA3c for detecting spatial and environmental novelty.. Hippocampus, 18 (10): (1064-73). [PMID:18651615]
13. Pelloux Y et al.. (2014) The subthalamic nucleus keeps you high on emotion: behavioral consequences of its inactivation.. Front Behav Neurosci, 8 (): (414). [PMID:25538581]

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