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血管紧张素II

血管收缩肽

规格或纯度: 90%

CAS编号: 4474-91-3
分子式: C₅₀H₇₁N₁₃O₁₂
分子量: 1046.18
PubChem编号: 172198

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货号 (SKU)	包装规格	是否现货	价格	数量
A107852-5mg	5mg	现货
A107852-10mg	10mg	现货
A107852-25mg	25mg	现货
A107852-100mg	100mg	现货

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基本描述

规格或纯度	90%
英文名称	Angiotensin Ⅱ, human
别名	Hypertensin II; Ang II; DRVYIHPF;
英文别名	Hypertensin II; Ang II; DRVYIHPF;Angiotensin II HUMAN;Asp-Arg-Val-Tyr-Ile-His-Pro-Phe;Angiotensin II
生化机理	内源性肽参与人体水和电解质的动态平衡，血压，生殖激素和性行为的周期性以及垂体激素的调节。
应用	A peptide involved in the regulation of blood pressure
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	本产品以一种（或多种）包装尺寸提供，并进行冷冻干燥。因此，内含物可能会覆盖小瓶的底部或壁，因此可能不容易看到。请参阅我们的常见问题解答和信息页面以获取有关处理的更多详细信息。如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，这些产品最多可以使用一周。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	产品介绍：有效的血管加压剂，强烈刺激肾上腺皮质产生和释放醛固酮。 Angiotensin II plays an important role in the regulation of blood pressure and has strong vasoconstrictive effects. It also stimulates the release of aldosterone from the adrenal gland and inhibits adenylate cyclase activity in spontaneously hypertensive rats. Angiotensin II increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase (MYLK). It also elicits an increase in voltage-dependent delayed rectifier K+ current in neurons and activates JAK2 in smooth muscle cells. Furthermore, angiotensin II activates FAK (p125FAK) and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. It also activates c-Src (p60c-src), ERK1/2, JNK, and p38α (p38 MAP Kinase) in vascular smooth muscle cells. The amino acid sequence Asp-Arg-Val-Tyr-Ile-His-Pro-Phe A peptide involved in the regulation of blood pressure

名称和标识符

IUPAC Name	(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
INCHI	InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1
InChi Key	CZGUSIXMZVURDU-JZXHSEFVSA-N
Canonical SMILES	CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
分子式	C₅₀H₇₁N₁₃O₁₂
PubChem CID	172198
分子量	1046.18

化学和物理性质

溶解性	insoluble in DMSO; insoluble in EtOH
密度	1.43
敏感性	热敏感

安全信息

WGK Germany	3
RTECS	BW2165000
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

参考文献

1. Wang L et al.. (2021) Adropin inhibits the phenotypic modulation and proliferation of vascular smooth muscle cells during neointimal hyperplasia by activating the AMPK/ACC signaling pathway.. Exp Ther Med, 21 (6): (560). [PMID:33850532]
2. Ageeva LV et al.. (2018) Data supporting that adipose-derived mesenchymal stem/stromal cells express angiotensin II receptors in situ and in vitro.. Data Brief, 16 (): (327-333). [PMID:29234689]
3. Yang L et al.. (2017) Effect of AMPK signal pathway on pathogenesis of abdominal aortic aneurysms.. Oncotarget, 8 (54): (92827-92840). [PMID:29190959]
4. Liu J et al.. (2022) Effects of angiotensin II combined with asparaginase and dexamethasone on the femoral head in mice: A model of steroid-induced femoral head osteonecrosis.. Front Cell Dev Biol, 10 (): (975879). [PMID:36187471]
5. Bao Q et al.. (2020) Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis.. Elife, 9 (): (). [PMID:31934850]
6. Yu C et al.. (2015) Knockdown of angiopoietin like-2 protects against angiotensin II-induced cerebral endothelial dysfunction in mice.. Am J Physiol Heart Circ Physiol, 308 (5): (H386-97). [PMID:25527773]
7. Sysoeva VY et al.. (2017) Local angiotensin II promotes adipogenic differentiation of human adipose tissue mesenchymal stem cells through type 2 angiotensin receptor.. Stem Cell Res, 25 (): (115-122). [PMID:29127873]
8. Li Q et al.. (2018) Megalin mediates plasma membrane to mitochondria cross-talk and regulates mitochondrial metabolism.. Cell Mol Life Sci, 75 (21): (4021-4040). [PMID:29916093]
9. Guo J et al.. (2022) Metformin protects against abdominal aortic aneurysm by Atg7-induced autophagy.. Adv Clin Exp Med, 31 (): (59-69). [PMID:34714980]
10. Wang Z et al.. (2019) Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE-/- mice.. Cell Biosci, 9 (): (68). [PMID:31467666]
11. Wang D et al.. (2022) Quercetin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and activation of JAK2/STAT3 pathway: A target based networking pharmacology approach.. Front Pharmacol, 13 (): (1002363). [PMID:36324691]
12. Xue H et al.. (2022) RIP3 Contributes to Cardiac Hypertrophy by Influencing MLKL-Mediated Calcium Influx.. Oxid Med Cell Longev, 2022 (): (5490553). [PMID:35464769]
13. Yang L et al.. (2016) Silencing of hypoxia inducible factor-1a gene attenuated angiotensin ?-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice.. Atherosclerosis, 252 (): (40-49). [PMID:27497884]
14. Duan J et al.. (2019) The cell-wide web coordinates cellular processes by directing site-specific Ca2+ flux across cytoplasmic nanocourses.. Nat Commun, 10 (): (2299). [PMID:31127110]
15. Yang S et al.. (2019) The role of STAT3/mTOR-regulated autophagy in angiotensin II-induced senescence of human glomerular mesangial cells.. Cell Signal, 53 (): (327-338). [PMID:30389500]

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