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2-氨基-4-甲基吡啶

规格或纯度: 98%
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货号 (SKU) 包装规格 是否现货 价格 数量
A107214-25g
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A107214-100g
100g 现货 Stock Image
A107214-250g
250g 现货 Stock Image
A107214-500g
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Inducible NOS Inhibitor

基本描述

规格或纯度 98%
英文名称 2-Amino-4-picoline
别名 2-氨基-4-皮考林
英文别名 2-amino-4-methylpyridine|695-34-1|4-METHYLPYRIDIN-2-AMINE|2-Amino-4-picoline|Ascensil|2-Pyridinamine, 4-methyl-|Aminopicoline|4-Methyl-2-pyridinamine|4-Methyl-2-aminopyridine|4-Methyl-2-pyridylamine|4-PICOLINE, 2-AMINO-|W 45 Raschig|Methyl-4 amino-2-pyrid
生化机理 2- 氨基 -4- 甲基吡啶体外抑制小鼠原始264.7细胞诱导型 no 合酶活性。
应用 A potent inhibitor of NOS2 (iNOS)
储存温度 2-8°C储存,充氩
运输条件 冰袋运输
产品介绍

2-Amino-4-methylpyridine is a potent inhibitor of NOS2 (iNOS) in vitro.A potent inhibitor of NOS2 (iNOS)

Product Description:

2-Amino-4-methylpyridine acts as ligand and forms methoxo-bridged copper(II) complexes.


Product Application:

2-Amino-4-methylpyridine has been used in the synthesis of 2-amino-4-methyl-pyridinium 2-hy?droxy?benzoate.

名称和标识符

EC号 211-780-9
IUPAC Name 4-methylpyridin-2-amine
INCHI InChI=1S/C6H8N2/c1-5-2-3-8-6(7)4-5/h2-4H,1H3,(H2,7,8)
InChi Key ORLGLBZRQYOWNA-UHFFFAOYSA-N
Canonical SMILES CC1=CC(=NC=C1)N
WGK Germany 3
RTECS TJ5150000
PubChem CID 1533
UN Number 2811
分子量 108.14
Beilstein号 107066
Reaxy-Rn 107066

化学和物理性质

溶解性 Soluble in water (41 mg/ml at 20 °C), lower alcohols (slightly), chloroform, ethyl acetate, and DMF.
密度 1.068
敏感性 对湿度敏感
闪点(℉) 244.4 °F
闪点(℃) 118 °C
沸点 230°C
熔点 96-101°C

安全和危险性(GHS)

象形图
ghs06

Toxic

ghs08

Health Hazard

ghs07

Harmful

信号词 Danger
危险声明 H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H301: Toxic if swallowed
H311: Toxic in contact with skin
H331: Toxic if inhaled
H373: Causes damage to organs through prolonged or repeated exposure
预防措施声明 P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P362+P364,P330,P361+P364,P264+P265,P301+P316,P337+P317,P332+P317,P316,P319
WGK Germany 3
RTECS TJ5150000
Reaxy-Rn 107066
Merck Index 466
个人防护装备 Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges

关联配体

Ligand ID 5111
名称 2-amino-4-methylpyridine
类别 Synthetic organic
学名 4-methylpyridin-2-amine
生物活性评价 The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价 Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth.

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参考文献

1. Faraci WS, Nagel AA, Verdries KA, Vincent LA, Xu H, Nichols LE, Labasi JM, Salter ED, Pettipher ER.  (1996)  2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo..  Br J Pharmacol,  119  (6):  (1101-8).  [PMID:8937711]
2. M Vlaskovska,I Krushkov.  (1989-01-01)  [Study of the effect of analgeton on the release of beta-endorphin and its effect on chronic hyperalgesia]..  Eksperimentalna meditsina i morfologiia,  28  ((3)):  (14-21).  [PMID:2530083]
3. K Simeonova,I Lambev,I Krushkov.  (1987-01-01)  [Baroreflex effects on systolic arterial pressure and the intersystolic period in a comparative study of aminton and phenylephrine]..  Eksperimentalna meditsina i morfologiia,  26  ((4)):  (18-22).  [PMID:3446484]
4. M W Fryer,W E Glover.  (1997-11-14)  Effects of 4-methyl-2-aminopyridine on [3H]-noradrenaline overflow and contractility of isolated rabbit arteries..  General pharmacology,  29  ((4)):  (657-663).  [PMID:9352318]
5. Sheela Sharma,Betty P Wilkinson,Pu Gao,Vernon E Steele.  (2002-06-26)  Differential activity of NO synthase inhibitors as chemopreventive agents in a primary rat tracheal epithelial cell transformation system..  Neoplasia (New York, N.Y.),  ((4)):  (332-336).  [PMID:12082549]
6. Sherif Y Saad,Tawfeeg A O Najjar,Mohammed H Daba,Ammar C Al-Rikabi.  (2003-04-04)  Inhibition of nitric oxide synthase aggravates cisplatin-induced nephrotoxicity: effect of 2-amino-4-methylpyridine..  Chemotherapy,  48  ((6)):  (309-315).  [PMID:12673106]
7. Ravil R Petrov,Ruben S Vardanyan,Yeon S Lee,Shou-wu Ma,Peg Davis,Lucinda J Begay,Josephine Y Lai,Frank Porreca,Victor J Hruby.  (2006-07-11)  Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity..  Bioorganic & medicinal chemistry letters,  16  ((18)):  (4946-4950).  [PMID:16828552]
8. Elsa D Garcin,Andrew S Arvai,Robin J Rosenfeld,Matt D Kroeger,Brian R Crane,Gunilla Andersson,Glen Andrews,Peter J Hamley,Philip R Mallinder,David J Nicholls,Stephen A St-Gallay,Alan C Tinker,Nigel P Gensmantel,Antonio Mete,David R Cheshire,Stephen Connolly,Dennis J Stuehr,Anders Aberg,Alan V Wallace,John A Tainer,Elizabeth D Getzoff.  (2008-10-14)  Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase..  Nature chemical biology,  ((11)):  (700-707).  [PMID:18849972]
9. Ullvi Bluhm,Jean-Luc Boucher,Uwe Buss,Bernd Clement,Friederike Friedrich,Ulrich Girreser,Dieter Heber,Thanh Lam,Michel Lepoivre,Mojgan Rostaie-Gerylow,Ulrich Wolschendorf.  (2009-01-16)  Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases..  European journal of medicinal chemistry,  44  ((7)):  (2877-2887).  [PMID:19144449]
10. Somnath Ray Choudhury,Biswajit Dey,Suranjana Das,Arturo Robertazzi,Atish Dipankar Jana,Chih-Yuan Chen,Hon Man Lee,Patrick Gamez,Subrata Mukhopadhyay.  (2009-09-18)  Robust recognition of malonate and 2-amino-4-picolinium in conjunction with M(II) as a triad (M = Ni/Co/Mn): role of this highly stable hydrogen-bonded motif in driving supramolecular self-assembly..  Dalton transactions (Cambridge, England : 2003),    ((37)(37)):  (7617-7624).  [PMID:19759933]
11. Biswarup Saha,Md Maidul Islam,Susmita Paul,Saheli Samanta,Shayoni Ray,Chitta Ranjan Santra,Somnath Ray Choudhury,Biswajit Dey,Amrita Das,Somnath Ghosh,Subrata Mukhopadhyay,Gopinatha Suresh Kumar,Parimal Karmakar.  (2010-04-13)  DNA binding ability and hydrogen peroxide induced nuclease activity of a novel Cu(II) complex with malonate as the primary ligand and protonated 2-amino-4-picoline as the counterion..  The journal of physical chemistry. B,  114  ((17)):  (5851-5861).  [PMID:20380411]
12. Jonita Stankevi?iūt?, Justas Vaitekūnas, Vytautas Petkevi?ius, Renata Gasparavi?iūt?, Daiva Taurait?, Rolandas Me?kys,.  (2016-12-17)  Oxyfunctionalization of pyridine derivatives using whole cells of Burkholderia sp. MAK1..  Scientific reports,    ():  ( 39129-39129 ).  [PMID:27982075]
13. N Kiloh,A L Harvey,W E Glover.  (1981-03-05)  Actions of 4-methyl-2-aminopyridine on neuromuscular transmission and contractility of skeletal muscle..  European journal of pharmacology,  70  ((1)):  (53-57).  [PMID:6260515]
14. F Bergmann,R Elam.  (1980-10-01)  On the mechanism of action of 2-amino-4-methylpyridine, a morphine-like analgesic..  Archives internationales de pharmacodynamie et de therapie,  247  ((2)):  (275-282).  [PMID:6449914]
15. W E Glover.  (1981-04-24)  Cholinergic effect of 4-aminopyridine and adrenergic effect of 4-methyl-2-aminopyridine in cardiac muscle..  European journal of pharmacology,  71  ((1)):  (21-31).  [PMID:7238587]
16. I Panova,I Kurshkov,P Uzunov.  (1981-01-01)  [Effect of aminton on noradrenaline and adrenaline depots in the rat heart]..  Eksperimentalna meditsina i morfologiia,  20  ((3)):  (166-170).  [PMID:7308123]
17. E R Pettipher,T A Hibbs,M A Smith,R J Griffiths.  (1997-08-01)  Analgesic activity of 2-amino-4-methylpyridine, a novel NO synthase inhibitor..  Inflammation research : official journal of the European Histamine Research Society ... [et al.],  46 Suppl 2  ():  (S135-S136).  [PMID:9297548]
18. Eun-Ae Jo,Ji-Hyun Lee,Chul-Ho Jun.  (2008-11-15)  Rhodium(I)-catalyzed one-pot synthesis of dialkyl ketones from methanol and alkenes through directed sp3 C-H bond activation of N-methylamine..  Chemical communications (Cambridge, England),  (44)  ((44)):  (5779-5781).  [PMID:19009079]
19. .  (2009-11-04)  Guide to Receptors and Channels (GRAC), 4th Edition..  British journal of pharmacology,  158 Suppl 1  ():  (S1-254).  [PMID:19883461]
20. Madhukar Hemamalini,Hoong-Kun Fun.  (2010-01-01)  2-Amino-4-methyl-pyridinium 2-hy-droxy-benzoate..  Acta crystallographica. Section E, Structure reports online,  66  ((Pt 8)):  (o2151-o2152).  [PMID:21588437]
21. G Anandha Babu,P Ramasamy.  (2011-09-02)  Growth and characterization of 2-amino-4-picolinium toluene sulfonate single crystal..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  82  ((1)):  (521-526).  [PMID:21880542]
22. I Bryndal,E Kucharska,W S?siadek,M Wandas,T Lis,J Lorenc,J Hanuza.  (2012-09-04)  Molecular and crystal structures, vibrational studies and quantum chemical calculations of 3 and 5-nitroderivatives of 2-amino-4-methylpyridine..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  96  ():  (952-962).  [PMID:22939283]

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