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1-氨基环丁烷羧酸

规格或纯度: 97%

CAS编号: 22264-50-2
分子式: H₂NC₄H₆CO₂H
分子量: 115.13
MDL号: MFCD00661068
PubChem编号: 89643

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货号 (SKU)	包装规格	是否现货	价格	数量
A102435-1g	1g	现货
A102435-5g	5g	现货
A102435-10g	10g	期货
A102435-25g	25g	期货

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基本描述

规格或纯度	97%
英文名称	1-Amino-1-cyclobutanecarboxylic acid
别名	1-氨基-1-环丁烷羧酸
英文别名	1-Aminocyclobutanecarboxylic acid
运输条件	常规运输
产品介绍	1-Amino-1-cyclobutanecarboxylic acid is an NMDA receptor antagonist acting at the glycine site.An NMDA receptor antagonist that acts at the glycine site 1-Amino-1-cyclobutanecarboxylic acid is an NMDA receptor antagonist acting at the glycine site. An NMDA receptor antagonist that acts at the glycine site

名称和标识符

IUPAC Name	1-aminocyclobutane-1-carboxylic acid
INCHI	InChI=1S/C5H9NO2/c6-5(4(7)8)2-1-3-5/h1-3,6H2,(H,7,8)
InChi Key	FVTVMQPGKVHSEY-UHFFFAOYSA-N
Canonical SMILES	C1CC(C1)(C(=O)O)N
分子式	H₂NC₄H₆CO₂H
PubChem CID	89643
分子量	115.13

化学和物理性质

溶解性	Soluble to 100 mM in Water
密度	1.29
熔点	261°C

安全信息

象形图	Harmful
信号词	Warning
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation H302: Harmful if swallowed
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319
WGK Germany	3
RTECS	GU1336000
个人防护装备	dust mask type N95 (US),Eyeshields,Faceshields,Gloves

参考文献

1. L C Washburn,T T Sun,B Byrd,R L Hayes,T A Butler. (1979-10-01) 1-aminocyclobutane[11C]carboxylic acid, a potential tumor-seeking agent.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 20 ((10)): (1055-1061). [PMID:231642]
2. R P Compton,W F Hood,J B Monahan. (1990-01-23) Evidence for a functional coupling of the NMDA and glycine recognition sites in synaptic plasma membranes.. European journal of pharmacology, 188 ((1)): (63-70). [PMID:2155123]
3. W F Hood,E T Sun,R P Compton,J B Monahan. (1989-02-28) 1-Aminocyclobutane-1-carboxylate (ACBC): a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor.. European journal of pharmacology, 161 ((2-3)): (281-282). [PMID:2542048]
4. K F Hübner,S Krauss,L C Washburn,W D Gibbs,E C Holloway. (1981-06-01) Tumor detection with 1-aminocyclopentane and 1-aminocyclobutane C-11-carboxylic acid using positron emission computerized tomography.. Clinical nuclear medicine, 6 ((6)): (249-252). [PMID:6971725]
5. J K Relton,P J Strijbos,A L Cooper,N J Rothwell. (1993-01-01) Dietary N-3 fatty acids inhibit ischaemic and excitotoxic brain damage in the rat.. Brain research bulletin, 32 ((3)): (223-226). [PMID:8374800]
6. E Gershonov,R Granoth,E Tzehoval,Y Gaoni,M Fridkin. (1996-11-22) 1-Aminocyclobutanecarboxylic acid derivatives as novel structural elements in bioactive peptides: application to tuftsin analogs.. Journal of medicinal chemistry, 39 ((24)): (4833-4843). [PMID:8941397]
7. Y Kosugi,N Oyamada,S Satoh,T Yoshioka,E Onodera,Y Yamada. (1997-03-01) Inhibition by 1-aminocyclobutane-1-carboxylate of the activity of 1-aminocyclopropane-1-carboxylate oxidase obtained from senescing petals of carnation (Dianthus caryophyllus L.) flowers.. Plant & cell physiology, 38 ((3)): (312-318). [PMID:9150604]
8. M Gatos,F Formaggio,M Crisma,C Toniolo,G M Bonora,Z Benedetti,B Di Blasio,R Iacovino,A Santini,M Saviano,J Kamphuis. (1997-03-01) Conformational characterization of the 1-aminocyclobutane-1-carboxylic acid residue in model peptides.. Journal of peptide science : an official publication of the European Peptide Society, 3 ((2)): (110-122). [PMID:9230476]
9. Atsushi Inanobe,Hiroyasu Furukawa,Eric Gouaux. (2005-07-06) Mechanism of partial agonist action at the NR1 subunit of NMDA receptors.. Neuron, 47 ((1)): (71-84). [PMID:15996549]
10. R H Porter,R S Briggs,P J Roberts. (1992-09-01) Modulation of [3H]3-((+-)-2-carboxypiperazin-4-yl)propyl-1-phosphonic acid ([3H]CPP) binding by ligands acting at the glycine and the polyamine sites of the rat brain NMDA receptor complex.. European journal of pharmacology, 227 ((1)): (83-88). [PMID:1426025]
11. T S Rao,J A Cler,R P Compton,M R Emmett,S Mick,E T Sun,S Iyengar,P L Wood. (1990-03-01) Neuropharmacological characterization of 1-aminocyclopropane-1-carboxylate and 1-aminocyclobutane-1-carboxylate, ligands of the N-methyl-D-aspartate-associated glycine receptor.. Neuropharmacology, 29 ((3)): (305-309). [PMID:2158004]
12. G B Watson,T H Lanthorn. (1990-08-01) Pharmacological characteristics of cyclic homologues of glycine at the N-methyl-D-aspartate receptor-associated glycine site.. Neuropharmacology, 29 ((8)): (727-730). [PMID:2177161]
13. I Varela,M Avila,J M Mato,L Hue. (1990-04-15) Insulin-induced phospho-oligosaccharide stimulates amino acid transport in isolated rat hepatocytes.. The Biochemical journal, 267 ((2)): (541-544). [PMID:2185744]
14. G B Watson,M A Bolanowski,M P Baganoff,C L Deppeler,T H Lanthorn. (1989-08-22) Glycine antagonist action of 1-aminocyclobutane-1-carboxylate (ACBC) in Xenopus oocytes injected with rat brain mRNA.. European journal of pharmacology, 167 ((2)): (291-294). [PMID:2556287]
15. V N Balaji,K Ramnarayan,M F Chan,S N Rao. (1995-05-01) Conformational studies on model peptides with 1-aminocyclobutane 1-carboxylic acid residues.. Peptide research, 8 ((3)): (178-186). [PMID:7670233]
16. Y Gaoni,A G Chapman,N Parvez,P C Pook,D E Jane,J C Watkins. (1994-12-09) Synthesis, NMDA receptor antagonist activity, and anticonvulsant action of 1-aminocyclobutanecarboxylic acid derivatives.. Journal of medicinal chemistry, 37 ((25)): (4288-4296). [PMID:7996540]
17. Cassandra L Kussius,Gabriela K Popescu. (2009-08-04) Kinetic basis of partial agonism at NMDA receptors.. Nature neuroscience, 12 ((9)): (1114-1120). [PMID:19648915]

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