Cas(131-48-6), N-乙酰神经氨酸-阿拉丁试剂, NAN;NANA;唾液酸;醋纽拉酸,N-Acetylneuraminic acid,

货号 (SKU)	包装规格	是否现货
A100555-100mg	100mg	现货
A100555-250mg	250mg	现货
A100555-1g	1g	现货
A100555-5g	5g	现货
A100555-10g	10g	现货
A100555-25g	25g	现货
A100555-100g	100g	现货

基本描述

规格或纯度	98%
英文名称	N-Acetylneuraminic acid
别名	NAN;NANA;唾液酸;醋纽拉酸;N-乙酰甘露糖胺丙酮酸; 5-乙酰氨基-3,5-双脱氧-D-丙三基-D-半乳糖唾液酸；N-(-)-乙酰甘露糖胺丙酮酸
英文别名	NAN;NANA; o-Sialic acid; Galactononulosonic acid; Lactaminic acid;5-Acetamido-3,5-dideoxy-D-glycero-D-galactonulosonic acid;Neu5Ac；N-(-)-Acetylneuraminic acid
储存温度	-20°C储存,充氩
运输条件	超低温冰袋运输
产品介绍	产品介绍: N-乙酰神经氨酸，俗称唾液酸，又名燕窝酸，是一种天然存在的氨基糖，它最初由牛颌下腺粘蛋白中分离而出，也因此而得名唾液酸。唾液酸是含有氨基的九碳单糖衍生物，是所有神经氨酸或酮基-脱氧壬酮糖酸(KDN)的N-或O-衍生物的总称。唾液酸通常以低聚糖，糖脂或者糖蛋白的形式存在，主要以短链残基的形式存在于糖蛋白和糖脂的末端。N-乙酰神经氨酸有几个已知的缀和形式来源，游离N-乙酰神经氨酸，寡糖唾液酸乳糖, 含唾液酸的神经节苷脂和酪蛋白巨肽（CMP，Macropeptide，也称为糖巨肽GMP，Glycomacropeptide，和酪蛋白糖巨肽cGMP，Caseinoglycomacropeptide）。用途： 1）细胞的营养液：? 唾液酸可起到免疫辅助剂的作用，提高肠道对维生素及矿物质的吸收，增强细胞免疫力的同时提升机体抗病力，从而提高免疫力。有很好的保健作用。长期食用，可有效改善身体状态，以良好的精神状态面对繁重的生活及工作。 2）大脑的营养品：? 生物医学研究中指出, 唾液酸可促进大脑神经細胞的资讯传达速度,通过与大脑細胞膜及突触的相互作用,提高大脑的反应速度。及时补充唾液酸，可有效促进大脑发育，从而提升身体能力。? 3）芳华永驻佳品：? 唾液酸对细胞具有保护和稳定作用，影响着新陈代谢中血球的寿命和酶蛋白的数量及活力，延缓细胞老化，唾液酸是养颜滋补的佳品，令肌肤幼滑有光泽，有效抗衰老。应用： 1）婴儿配方食品： N-乙酰神经氨酸是大脑神经节苷脂的重要组成部分。神经细胞膜的N-乙酰神经氨酸含量是其他细胞的20倍，由于大脑信息传递及神经冲动的传导必须通过突触来实现，而N-乙酰神经氨酸是作用于大脑细胞膜和突触的脑部营养素，所以N-乙酰神经氨酸能够促进记忆力和智力的发育。研究发现，增加哺乳期饮食中的N-乙酰神经氨酸含量，婴儿脑中的N-乙酰神经氨酸含量会增加，与学习相关的基因表达水平会增加，从而增强其学习和记忆能力。神经细胞稳定的突触链接是记忆形成的结构基础，而N-乙酰神经氨酸是神经细胞膜及突触的营养素，可促进神经细胞的分化、发育和再生。许多著名婴儿配方制造商宣称在其配方奶粉中添加唾液酸 (N-乙酰神经氨酸) 。马来西亚卫生部已在 2003年将唾液酸批准在容许使用的营养标签内。在东南亚市场上销售的美赞臣、卡洛塔妮、美素和雪印等婴儿配方奶粉，其营养成分表中明确注明唾液酸含量。随着市场的推广，唾液酸在婴幼儿乳粉和辅食中的市场容量将会有一个飞速的发展。 2）食品营养补充剂： N-乙酰神经氨酸能消耗有毒过氧化氢。日本学者在有添加N-乙酰神经氨酸的培养基中观察过氧化氢对细胞的毒性，证实N-乙酰神经氨酸能够抑制由过氧化氢引起的细胞死亡。结果说明N-乙酰神经氨酸可以作为活性氧清除剂。同时N-乙酰神经氨酸的抗炎效果也非常好，还可以提高肠道对维生素及矿物质的吸收。含唾液酸的糖果在日本很受欢迎，在糖果中N-乙酰神经氨酸作为营养的补充剂。 3）抗流感和抗老年痴呆类药物： N-乙酰神经氨酸相关医学研究很多，大量用在药物中间体领域，具有一定规模的市场。国际上药物前体市场的容量比较大的是抗流感特效药扎那米韦(Zanamivir)，是一个有效的流感病毒N-乙酰神经氨酸抑制剂，用于流感的预防和治疗，合成过程是通过对N-乙酰神经氨酸单体进行修饰而来。 N-乙酰神经氨酸对神经细胞具有保护与稳定作用。位于神经细胞膜表面的蛋白酶与N-乙酰神经氨酸结合后，能不被细胞外蛋白酶降解。一些神经性疾病，如早老年性痴呆及精神分裂等患者的血液或脑中N-乙酰神经氨酸含量会下降，经药物治疗康复后，N-乙酰神经氨酸含量又恢复正常，这表明N-乙酰神经氨酸参与了神经细胞代谢。 4）化妆品：日本已开发含N-乙酰神经氨酸软膏和喷雾剂，保持头发健康生长。该产品被作为化妆品而不是药物出售。由于最近的研究发现的N-乙酰神经氨酸拥有的抗氧化作用，可以合理地添加到化妆品面霜或者乳霜中，给N-乙酰神经氨酸带来了巨大的潜在市场。

名称和标识符

EC号	205-023-1
IUPAC Name	(2S,4S,5R,6R)-5-acetamido-2,4-dihydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
INCHI	InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,7+,8+,9+,11-/m0/s1
InChi Key	SQVRNKJHWKZAKO-PFQGKNLYSA-N
Canonical SMILES	CC(=O)NC1C(CC(OC1C(C(CO)O)O)(C(=O)O)O)O
分子式	C₁₁H₁₉NO₉
PubChem CID	445063
Beilstein号	1716283
分子量	309.27

化学和物理性质

溶解性	Soluble in water (50 mg/ml).
敏感性	对湿度&空气& 热敏感
熔点	192-194°C
比旋光度	-32 ° (C=1, H2O)

安全信息

象形图	Harmful
信号词	Warning
危险声明	H319: Causes serious eye irritation
预防措施声明	P305+P351+P338,P280,P264+P265,P337+P317
WGK Germany	3
Reaxy-Rn	1716283
Merck Index	8484
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

参考文献

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