Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	360	12q15	Hcar2	hydroxycarboxylic acid receptor 2
Human	7	363	12q24.31	HCAR2	hydroxycarboxylic acid receptor 2
Mouse	7	360	5 F	Hcar2	hydroxycarboxylic acid receptor 2

RefSeq Protein	NP_852141 (Rn) , NP_808219 (Hs) , NP_109626 (Mm)
UniProtKB	Q80Z39 (Rn) , Q8TDS4 (Hs) , Q9EP66 (Mm)
OMIM	609163 (Hs)
RefSeq Nucleotide	NM_177551 (Hs) , NM_181476 (Rn) , NM_030701 (Mm)
Entrez Gene	338442 (Hs) , 353250 (Rn) , 80885 (Mm)
Ensembl Gene	ENSG00000182782 (Hs) , ENSMUSG00000045502 (Mm) , ENSRNOG00000026653 (Rn)
Protein GI	31324560 (Rn) , 13507640 (Mm) , 29171311 (Hs)
GPCRdb	hcar2_human (Hs) , hcar2_mouse (Mm) , hcar2_rat (Rn)
UniProtKB ID/Entry name	HCAR2_HUMAN (Hs) , HCAR2_MOUSE (Mm) , HCAR2_RAT (Rn)
DrugBank Target	Q8TDS4 (Hs)
ChEMBL Target	CHEMBL4420 (Mm) , CHEMBL4731 (Rn) , CHEMBL3785 (Hs)

Ligand Id	Ligand	Ligand Type	Action on Target	对应产品货号	产品名称
1589	(+)-5-(5-bromothiophen-3-yl)-5-methyl-4-oxo-4,5-dihydro-furan-2-carboxylic acid	Synthetic organic	Full agonist	B607203	(+)-5-(5-bromothiophen-3-yl)-5-methyl-4-oxo-4,5-dihydro-furan-2-carboxylic acid
1590	3-pyridine-acetic acid	Metabolite	Full agonist
1591	5-butyl-1H-pyrazole-3-carboxylic acid	Synthetic organic	Partial agonist	L287351	LUF 6283,HCA2（GPR109A）部分激动剂
1592	5-methyl nicotinic acid	Synthetic organic	Full agonist	M111432	5-甲基烟酸
1593	β-D-hydroxybutyric acid	Metabolite	Full agonist	S161108	DL-3-羟基丁酸(含高分子酯化产品)
1593	β-D-hydroxybutyric acid	Metabolite	Full agonist	S161108	DL-3-羟基丁酸(含高分子酯化产品)
1594	[3H]nicotinic acid	Synthetic organic	Full agonist	N103652	烟酸
1595	acifran	Synthetic organic	Full agonist	A288225	Acifran,受体激动剂
1596	acipimox	Synthetic organic	Full agonist	A129989	阿西莫司
1588	nicotinic acid	Metabolite	Full agonist	N103654	烟酸
5784	MK 0354	Synthetic organic	Partial agonist	M611905	MK 0354
5785	MK 1903	Synthetic organic	Full agonist	M611911	MK 1903
5786	monomethyl fumarate	Synthetic organic	Full agonist	M158861	富马酸单甲酯
5786	monomethyl fumarate	Synthetic organic	Full agonist	M158861	富马酸单甲酯
3203	cinnamic acid	Synthetic organic	Full agonist	T136978	(停产)反肉桂酸
5787	para-coumaric acid	Synthetic organic	Full agonist	C108515	4-香豆酸
5788	MK 6892	Synthetic organic	Full agonist	M126295	MK-6892
5788	MK 6892	Synthetic organic	Full agonist	M126295	MK-6892
5789	compound 21 [PMID: 21185185]	Synthetic organic	Full agonist	R608937	(4R)-2-[[(2S)-2-amino-3-[3-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]-4-methylcyclohexene-1-carboxylic acid
5790	compound (+)17a [PMID: 20363624]	Synthetic organic	Full agonist	H608782	7-(2H-tetrazol-5-yl)-8,9-diazatricyclo[4.3.0.02,4]nona-1(6),7-diene
5791	compound 2g [PMID: 19309152]	Synthetic organic	Full agonist	H609064	2-[3-(7-hydroxy-4,5-dihydropyrazolo[1,5-a]quinolin-3-yl)propanoylamino]benzoic acid
5792	compound 1q [PMID: 18029181]	Synthetic organic	Partial agonist	O608902	2-[[4-(6-oxo-4H-quinoxalin-2-yl)piperazine-1-carbonyl]amino]benzoic acid
5793	compound 8f [PMID: 20615702]	Synthetic organic	Full agonist	M609457	5-(2-methylpyrazol-3-yl)-1,4,5,6-tetrahydrocyclopenta[d]pyrazole-3-carboxylic acid
5794	compound 42 [PMID: 22420767]	Synthetic organic	Positive	D609225	3-(3,4-dichlorocyclohexyl)-7-methyl-N-(2-phenoxyethyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide
5795	compound 9n [PMID: 18752940]	Synthetic organic	Positive	M609483	7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide
8469	SCH 900271	Synthetic organic	Agonist	S613497	SCH 900271
8470	GSK256073	Synthetic organic	Agonist	G610704	GSK256073
1059	butyric acid	Metabolite	Agonist	B431361	丁酸