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Can recombinant proteins of different species be cross-used?

Can recombinant proteins of different species be cross-used?

The interspecific cross activity of the recombinant protein needs to be determined according to the specific product; It is suggested to select the recombinant protein of corresponding species as much as possible. The following information is for reference if the species cannot be matched:

a . Most human cytokines are effective on mouse cells (with only a few exceptions).

b . Most mouse cytokines are effective on human cells, but their specificity may not be strong. For example, mouse epidermal growth factor (EGF) has activity on human epidermal cells, and may also have effect on other types of human cells.

c . Interferon, GM-CSF, IL-3, and IL-4 are species-specific, that is, these cytokines of recombinant human can only act on human cells, and on mice, rats and other species, while these cytokines of recombinant mice are only used in mice, and have no effect on human cells.

d. Fibroblast growth factors (FGFs), neurotrophins (such as BDNGF, GDNF, CNTF β- NGF, etc.), TGF- β?It is highly conservative and has strong cross activity among various genera.

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