Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	2	434	3q13.33	NR1I2	nuclear receptor subfamily 1 group I member 2
Mouse	2	431	16 B3	Nr1i2	nuclear receptor subfamily 1, group I, member 2
Rat	2	431	11q21	Nr1i2	nuclear receptor subfamily 1, group I, member 2

Entrez Gene	8856 (Hs) , 84385 (Rn) , 18171 (Mm)
OMIM	603065 (Hs)
UniProtKB	O75469 (Hs) , Q9R1A7 (Rn) , O54915 (Mm)
RefSeq Nucleotide	NM_033013 (Hs) , NM_052980 (Rn) , NM_010936 (Mm) , NM_001098404 (Mm) , NM_003889 (Hs) , NM_022002 (Hs)
RefSeq Protein	NP_071285 (Hs) , NP_035066 (Mm) , NP_443212 (Rn) , NP_003880 (Hs) , NP_148934 (Hs) , NP_001091874 (Mm)
Ensembl Gene	ENSG00000144852 (Hs) , ENSMUSG00000022809 (Mm) , ENSRNOG00000002906 (Rn)
Protein GI	16418481 (Rn) , 148536879 (Mm) , 34398348 (Hs)
NURSA Receptor	10.1621/IS7XZIEP9G (Hs)
DrugBank Target	O75469 (Hs)
CATH/Gene3D	3.30.50.10 (N/A)
ChEMBL Target	CHEMBL3401 (Hs) , CHEMBL2146315 (Rn) , CHEMBL1743244 (Mm)

Ligand Id	Ligand	Ligand Type	Action on Target	对应产品货号	产品名称
2763	SR12813	Synthetic organic	Agonist	S274978	SR-12813,PXR激动剂
2762	pregnenolone-16α-carbonitrile	Synthetic organic	Agonist	P275425	孕烯醇酮-16α-腈
2764	hyperforin	Natural product	Agonist	H275963	贯叶金丝桃素
2765	rifampicin	Natural product	Agonist	R105455	利福平
611	lithocholic acid	Metabolite	Agonist	L106779	石胆酸
2766	3-keto-lithocholic acid	Metabolite	Agonist	O351925	3-氧代-5β-胆烷酸
2803	5β-cholestane-3α,7α,12α-triol	Metabolite	Agonist	T336731	三羟基前列腺素
2803	5β-cholestane-3α,7α,12α-triol	Metabolite	Agonist	T336731	三羟基前列腺素
2768	dexamethasone	Synthetic organic	Agonist
2773	S20	Synthetic organic	Agonist	S613358	S20
2772	(+)-S20	Synthetic organic	Agonist	S613359	(+)-S20
2769	schisandrin A	Natural product	Agonist	S115189	五味子甲素
2769	schisandrin A	Natural product	Agonist	S115189	五味子甲素
2770	paclitaxel	Natural product	Agonist	P106868	紫杉醇
2771	vitamin K2	Metabolite	Agonist	V614755	vitamin K2
2514	nifedipine	Synthetic organic	Agonist	N123275	硝苯地平
2330	clotrimazole	Synthetic organic	Agonist	C129965	克霉唑
2804	phenobarbital	Synthetic organic	Agonist	P612793	phenobarbital
2805	mifepristone	Synthetic organic	Agonist	M126999	米非司酮
2774	trabectedin	Natural product	Antagonist	T128049	他比特啶
2759	5β-pregnane-3,20-dione	Synthetic organic	Agonist	D336733	5β-二氢孕酮
1013	17β-estradiol	Metabolite	Agonist
2739	lovastatin	Natural product	Full agonist	L107709	洛伐他汀
10734	garcinoic acid	Natural product	Agonist	G610503	garcinoic acid
10734	garcinoic acid	Natural product	Agonist	G610503	garcinoic acid

1. Williams RJ.  (1988)  Self-assembling surfaces..  Nature,  332  (6163):  (393).  [PMID:3352739]

2. Adachi M, Yang YY, Furuichi Y, Miyamoto C.  (1991)  Cloning and characterization of cDNA encoding human A-type endothelin receptor..  Biochem Biophys Res Commun,  180  (3):  (1265-72).  [PMID:1719979]

3. Cyr C, Huebner K, Druck T, Kris R.  (1991)  Cloning and chromosomal localization of a human endothelin ETA receptor..  Biochem Biophys Res Commun,  181  (1):  (184-90).  [PMID:1659806]

4. Hosoda K, Nakao K, Hiroshi-Arai, Suga S, Ogawa Y, Mukoyama M, Shirakami G, Saito Y, Nakanishi S, Imura H.  (1991)  Cloning and expression of human endothelin-1 receptor cDNA..  FEBS Lett,  287  (1-2):  (23-6).  [PMID:1652463]