Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	6	871	12q24.11	TRPV4	transient receptor potential cation channel subfamily V member 4
Rat	6	871	12q16	Trpv4	transient receptor potential cation channel, subfamily V, member 4
Mouse	6	871	5 F	Trpv4	transient receptor potential cation channel, subfamily V, member 4

OMIM	605427 (Hs)
Entrez Gene	66026 (Rn) , 63873 (Mm) , 59341 (Hs)
RefSeq Protein	NP_067638 (Hs) , NP_076460 (Rn) , NP_071300 (Mm)
RefSeq Nucleotide	NM_021625 (Hs) , NM_023970 (Rn) , NM_022017 (Mm)
Ensembl Gene	ENSG00000111199 (Hs) , ENSMUSG00000014158 (Mm) , ENSRNOG00000001195 (Rn)
UniProtKB	Q9HBA0 (Hs) , Q9ERZ8 (Rn) , Q9EPK8 (Mm)
Orphanet	171081 (Hs)
Protein GI	13027424 (Rn) , 269784723 (Mm) , 294459977 (Hs)
CATH/Gene3D	1.25.40.20 (N/A)
ChEMBL Target	CHEMBL3119 (Hs) , CHEMBL6126 (Mm) , CHEMBL2775 (Rn)

Ligand Id	Ligand	Ligand Type	Action on Target	对应产品货号	产品名称
2500	4α-PDD	Metabolite	Agonist	P337807	(停产)4α-佛波醇 12,13-二癸酸酯
2500	4α-PDD	Metabolite	Agonist	P337807	(停产)4α-佛波醇 12,13-二癸酸酯
6304	5,6-epoxyeicosatrienoic acid	Metabolite	Agonist	E607205	5,6-epoxyeicosatrienoic acid
2502	bisandrographolide	Natural product	Agonist	B608099	bisandrographolide
2478	citric acid	Metabolite	Agonist	C108872	无水柠檬酸
2341	phorbol 12-myristate 13-acetate	Synthetic organic	Agonist	P167764	佛波醇12-十四酸酯13-乙酸酯
2341	phorbol 12-myristate 13-acetate	Synthetic organic	Agonist	P167764	佛波醇12-十四酸酯13-乙酸酯
2432	ruthenium red	Inorganic	Antagonist
4205	GSK1016790A	Synthetic organic	Activation	G275374	GSK-1016790A,新型有效的TRPV4通道激动剂
4295	RN1747	Synthetic organic	Activation	R276121	1-苄基-4-（4-氯-2-硝基苯基）磺酰基哌嗪(PSB 06126)
2426	Gd3+	Inorganic	None
2434	La3+	Inorganic	None
4205	GSK1016790A	Synthetic organic	Activation	G275374	GSK-1016790A,新型有效的TRPV4通道激动剂
4205	GSK1016790A	Synthetic organic	Activation	G275374	GSK-1016790A,新型有效的TRPV4通道激动剂
4105	4α-PDH	Synthetic organic	Activation	P607179	4α-PDH
4295	RN1747	Synthetic organic	Activation	R276121	1-苄基-4-（4-氯-2-硝基苯基）磺酰基哌嗪(PSB 06126)
4295	RN1747	Synthetic organic	Activation	R276121	1-苄基-4-（4-氯-2-硝基苯基）磺酰基哌嗪(PSB 06126)
4294	RN1734	Synthetic organic	Inhibition	R276507	RN-1734,TRPV4拮抗剂
4294	RN1734	Synthetic organic	Inhibition	R276507	RN-1734,TRPV4拮抗剂
4294	RN1734	Synthetic organic	Inhibition	R276507	RN-1734,TRPV4拮抗剂
4213	HC067047	Synthetic organic	Inhibition	H276201	HC 067047,可逆TRPV4拮抗剂
4213	HC067047	Synthetic organic	Inhibition	H276201	HC 067047,可逆TRPV4拮抗剂
4213	HC067047	Synthetic organic	Inhibition	H276201	HC 067047,可逆TRPV4拮抗剂
6465	GSK2193874	Synthetic organic	Inhibition	G287297	GSK 2193874,TRPV4拮抗剂
6465	GSK2193874	Synthetic organic	Inhibition	G287297	GSK 2193874,TRPV4拮抗剂
6465	GSK2193874	Synthetic organic	Inhibition	G287297	GSK 2193874,TRPV4拮抗剂
2432	ruthenium red	Inorganic	Inhibition
2391	arachidonic acid	Metabolite	Activation	A111764	花生四烯酸(AA)
10304	RN-9893	Synthetic organic	Antagonist	R613222	RN-9893
10304	RN-9893	Synthetic organic	Antagonist	R613222	RN-9893
11165	Crotamiton	Synthetic organic	Inhibition	N102062	克罗米通
11238	NSC151066	Synthetic organic	Inhibition	N612408	NSC151066
11239	NSC212069	Synthetic organic	Inhibition	N612411	NSC212069
11240	NSC600684	Synthetic organic	Inhibition	N612413	NSC600684
12553	puerarin	Natural product	Activation	P111269	葛根素
7000	curcumin	Natural product	Activation
6310	vildagliptin	Synthetic organic	Activation	V125454	维达列汀 (LAF-237)
12554	quinazolin-4(3H) derivative 36	Synthetic organic	Activation	Q613050	quinazolin-4(3H) derivative 36
12555	cimifugin	Natural product	Inhibition	C414317	升麻素
5239	paracetamol	Synthetic organic	Inhibition
12556	AM404	Synthetic organic	Inhibition	A607584	AM404
5464	propofol	Synthetic organic	Inhibition	D106369	2,6-二异丙基苯酚
12557	GSK2798745	Synthetic organic	Inhibition	G610709	GSK2798745
12558	GSK-Bz derivative 2b	Synthetic organic	Inhibition	G610738	GSK-Bz derivative 2b