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Raf-1 proto-oncogene, serine/threonine kinase
| Target Id | 2184 |
|---|---|
| 缩写名 | c-Raf |
| 家族 | RAF family |
基因和蛋白信息
数据库链接
| Ensembl Gene | ENSG00000132155 (Hs) , ENSMUSG00000000441 (Mm) , ENSRNOG00000010153 (Rn) |
|---|---|
| Entrez Gene | 5894 (Hs) , 24703 (Rn) , 110157 (Mm) |
| OMIM | 164760 (Hs) |
| UniProtKB | P04049 (Hs) , P11345 (Rn) , Q99N57 (Mm) |
| RefSeq Nucleotide | NM_002880 (Hs) , NM_012639 (Rn) , NM_029780 (Mm) |
| RefSeq Protein | NP_002871 (Hs) , NP_036771 (Rn) , NP_084056 (Mm) |
| Orphanet | 138722 (Hs) |
| Protein GI | 4506401 (Hs) , 18497290 (Mm) , 6981458 (Rn) |
| DrugBank Target | P04049 (Hs) |
| ChEMBL Target | CHEMBL1906 (Hs) , CHEMBL3804748 (Mm) |
作用于该靶标的配体
| Ligand Id | Ligand | Ligand Type | Action on Target | 对应产品货号 | 产品名称 |
|---|---|---|---|---|---|
| 5893 | vemurafenib | Synthetic organic | Inhibition | V127521 | 维罗非尼(PLX4032,RG7204) |
| 8072 | GW5074 | Synthetic organic | Inhibition | G129612 | GW5074,c-Raf1激酶抑制剂 |
| 7880 | agerafenib | Synthetic organic | Inhibition | C126457 | CEP-32496 |
| 5711 | sorafenib | Synthetic organic | Inhibition | S125098 | 索拉非尼 |
| 8943 | LY3009120 | Synthetic organic | Inhibition | L288815 | LY 3009120,泛Raf激酶抑制剂 |
| 9129 | L779450 | Synthetic organic | Inhibition | L169419 | L-779450,Raf激酶抑制剂 |
| 9130 | ZM336372 | Synthetic organic | Inhibition | Z129624 | ZM 336372,c-Raf抑制剂 |
| 9131 | plixorafenib | Synthetic organic | Inhibition | P413892 | PLX8394 |
| 9383 | OSI-930 | Synthetic organic | Inhibition | O126155 | OSI-930,Kit (c-Kit)， KDR和CSF-1R抑制剂 |
| 9389 | SB590885 | Synthetic organic | Inhibition | S613463 | SB590885 |
| 9815 | CCT196969 | Synthetic organic | Inhibition | C413825 | CCT196969 |
| 9814 | CCT241161 | Synthetic organic | Inhibition | C608424 | CCT241161 |
| 9925 | balamapimod | Synthetic organic | Inhibition | B607919 | balamapimod |
| 10387 | TAK-632 | Synthetic organic | Inhibition | T413733 | TAK-632 |
| 10387 | TAK-632 | Synthetic organic | Inhibition | T413733 | TAK-632 |
| 10389 | RIPK3 inhibitor 18 | Synthetic organic | Inhibition | R613202 | RIPK3 inhibitor 18 |
| 10658 | naporafenib | Synthetic organic | Inhibition | N414150 | Naporafenib |
| 11544 | belvarafenib | Synthetic organic | Inhibition | B414223 | Belvarafenib (HM95573) |
| 11867 | avutometinib | Synthetic organic | Inhibition | R413717 | RO5126766 (CH5126766) |
| 12095 | exarafenib | Synthetic organic | Inhibition | E610261 | exarafenib |
| 12096 | tinlorafenib | Synthetic organic | Inhibition | T614465 | tinlorafenib |
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