Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	2	364	22q13.33	MAPK11	mitogen-activated protein kinase 11
Mouse	2	364	15 E3	Mapk11	mitogen-activated protein kinase 11
Rat	2	364	7q34	Mapk11	mitogen-activated protein kinase 11

Ensembl Gene	ENSG00000185386 (Hs) , ENSMUSG00000053137 (Mm) , ENSRNOG00000006984 (Rn)
Entrez Gene	19094 (Mm) , 689314 (Rn) , 5600 (Hs)
OMIM	602898 (Hs)
Protein GI	20128774 (Hs) , 201023331 (Rn) , 168693637 (Mm)
UniProtKB	Q15759 (Hs) , Q9WUI1 (Mm)
RefSeq Nucleotide	NM_001109532 (Rn) , NM_002751 (Hs) , NM_011161 (Mm)
RefSeq Protein	NP_001103002 (Rn) , NP_002742 (Hs) , NP_035291 (Mm)
DrugBank Target	Q15759 (Hs)
ChEMBL Target	CHEMBL4335 (Mm) , CHEMBL3961 (Hs)

Ligand Id	Ligand	Ligand Type	Action on Target	对应产品货号	产品名称
5269	SB203580	Synthetic organic	Inhibition	S131899	SB-203580,p38 MAPK抑制剂
6059	VX-702	Synthetic organic	Inhibition	V125198	VX-702,p38 MAP激酶抑制剂
7817	talmapimod	Synthetic organic	Inhibition	S339037	SCIO 469盐酸盐
7818	PH-797804	Synthetic organic	Inhibition	P127738	PH-797804,ATP竞争性p38α抑制剂
5719	neflamapimod	Synthetic organic	Inhibition	V126681	VX-745,p38 alpha MAPK抑制剂
5668	doramapimod	Synthetic organic	Inhibition	D125100	达马莫德
9328	TAK-715	Synthetic organic	Inhibition	T125460	TAK-715
9915	pamapimod	Synthetic organic	Inhibition	P413914	帕马皮莫德
9917	pexmetinib	Synthetic organic	Inhibition	P413835	Pexmetinib (ARRY-614)
12122	compound 4e [PMID: 35546685]	Synthetic organic	Inhibition	T609257	1-[5-tert-butyl-2-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]pyrazol-3-yl]-3-[(1S,4R)-4-[[3-[(2S)-2-methylpiperidin-1-yl]-[1,2,4]triazolo[4,3-a]pyridin-6-yl]oxy]-1,2,3,4-tetrahydronaphthalen-1-yl]urea

1. Bech-Hansen NT, Naylor MJ, Maybaum TA, Pearce WG, Koop B, Fishman GA, Mets M, Musarella MA, Boycott KM.  (1998)  Loss-of-function mutations in a calcium-channel alpha1-subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness..  Nat Genet,  19  (3):  (264-7).  [PMID:9662400]

2. Singh A, Hamedinger D, Hoda JC, Gebhart M, Koschak A, Romanin C, Striessnig J.  (2006)  C-terminal modulator controls Ca2+-dependent gating of Ca(v)1.4 L-type Ca2+ channels..  Nat Neurosci,  9  (9):  (1108-16).  [PMID:16921373]

3. Strom TM, Nyakatura G, Apfelstedt-Sylla E, Hellebrand H, Lorenz B, Weber BH, Wutz K, Gutwillinger N, Rüther K, Drescher B et al..  (1998)  An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness..  Nat Genet,  19  (3):  (260-3).  [PMID:9662399]