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vilanterol

别名	GW642444X
Compound Class	Synthetic organic
变动原因	Vilanterol is an ultra-long-acting β2-adrenoreceptor agonist, belonging to a group of drugs termed ultra-LABAs.
Related Product	维兰特罗

Summary

是否批准为药物？	(FDA (2013))
IUPAC Name	4-[(1R)-2-[(6-{2-[(2,6-dichlorophenyl)methoxy]ethoxy}hexyl)amino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol
别名	GW642444X

数据库链接

ChEMBL Ligand	CHEMBL1198857
PubChem CID	10184665
CAS Registry No.	503068-34-6
Wikipedia	Vilanterol
DrugCentral Ligand	4799
GPCRdb Ligand	7353

生物活性

生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
关联靶标	β₂-adrenoceptor

临床资料

Summary of Clinical Use	Vilanterol is contained in medications alongside a corticosteroid (eg furoate (PubChem CID 9854489 and vilanterol marketed as Breo Ellipta®) or an anticholinergic drug ( and vilanterol marketed as Anoro Ellipta®). Both of these medications were approved by the US FDA in 2013 to treat chronic obstructive pulmonary disease (COPD). In Europe, the EMA has approved Relvar Ellipta® (fluticasone furoate and vilanterol) for asthma and COPD. In May 2015, the US FDA expanded approval of Breo Ellipta® to include treatment of asthma.
作用机制与药效学效应	Vilanterol is a long-acting β₂-adrenoceptor agonist. Upon inhalation, the drug activates airway β₂-adrenoceptors which causes vasodilation of airway smooth muscle and eases breathing. The corticosteroid component of the combination drug activates the glucocorticoid receptor (GR), helping to reduce the release of pro-inflammatory chemicals in the damaged lung, thereby futher aiding breathing.

结构

Canonical SMILES	OCc1cc(ccc1O)C(CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O
Isomeric SMILES	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O
InChI	InChI=1S/C24H33Cl2NO5/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28/h5-9,14,24,27-30H,1-4,10-13,15-17H2/t24-/m0/s1
InChI key	DAFYYTQWSAWIGS-DEOSSOPVSA-N

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